PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of bmcsysbioBioMed Centralsearchsubmit a manuscriptregisterthis articleBMC Systems Biology
 
BMC Syst Biol. 2012; 6: 52.
Published online May 30, 2012. doi:  10.1186/1752-0509-6-52
PMCID: PMC3411424
AlzPathway: a comprehensive map of signaling pathways of Alzheimer’s disease
Satoshi Mizuno,#1 Risa Iijima,#1 Soichi Ogishima,corresponding author#1 Masataka Kikuchi,#1 Yukiko Matsuoka,2,3 Samik Ghosh,2 Tadashi Miyamoto,1 Akinori Miyashita,4 Ryozo Kuwano,4 and Hiroshi Tanaka1
1Department of Bioinformatics, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo, 113-8510, Japan
2Systems Biology Institute, Shirokanedai 5-6-9, Minato-ku, Tokyo, 108-0071, Japan
3JST ERATO Kawaoka Infection-induced Host Response Network Project, The Institute of Medical Science, University of Tokyo, Bld 2, 4F, 4-6-1 Shirokanedai, Minato, Tokyo, 108-8639, Japan
4Department of Molecular Genetics, Center for Bioresources, Brain Research Institute, Niigata University, Niigata, 951-8585, Japan
corresponding authorCorresponding author.
#Contributed equally.
Satoshi Mizuno: mizuno/at/bioinfo.tmd.ac.jp; Risa Iijima: riijima/at/bioinfo.tmd.ac.jp; Soichi Ogishima: ogishima/at/sysbioevo.org; Masataka Kikuchi: kikuchi/at/bioinfo.tmd.ac.jp; Yukiko Matsuoka: myukiko/at/sbi.jp; Samik Ghosh: ghosh/at/sbi.jp; Tadashi Miyamoto: miyamoto/at/bioinfo.tmd.ac.jp; Akinori Miyashita: miyashi/at/bri.niigata-u.ac.jp; Ryozo Kuwano: ryosun/at/bri.niigata-u.ac.jp; Hiroshi Tanaka: htanaka/at/bioinfo.tmd.ac.jp
Received February 14, 2012; Accepted May 30, 2012.
Abstract
Background
Alzheimer’s disease (AD) is the most common cause of dementia among the elderly. To clarify pathogenesis of AD, thousands of reports have been accumulating. However, knowledge of signaling pathways in the field of AD has not been compiled as a database before.
Description
Here, we have constructed a publicly available pathway map called “AlzPathway” that comprehensively catalogs signaling pathways in the field of AD. We have collected and manually curated over 100 review articles related to AD, and have built an AD pathway map using CellDesigner. AlzPathway is currently composed of 1347 molecules and 1070 reactions in neuron, brain blood barrier, presynaptic, postsynaptic, astrocyte, and microglial cells and their cellular localizations. AlzPathway is available as both the SBML (Systems Biology Markup Language) map for CellDesigner and the high resolution image map. AlzPathway is also available as a web service (online map) based on Payao system, a community-based, collaborative web service platform for pathway model curation, enabling continuous updates by AD researchers.
Conclusions
AlzPathway is the first comprehensive map of intra, inter and extra cellular AD signaling pathways which can enable mechanistic deciphering of AD pathogenesis. The AlzPathway map is accessible at http://alzpathway.org/.
Articles from BMC Systems Biology are provided here courtesy of
BioMed Central