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Logo of bmcpediBioMed Centralsearchsubmit a manuscriptregisterthis articleBMC Pediatrics
 
BMC Pediatr. 2012; 12: 81.
Published online Jun 21, 2012. doi:  10.1186/1471-2431-12-81
PMCID: PMC3411420
Systematic literature review assessing tobacco smoke exposure as a risk factor for serious respiratory syncytial virus disease among infants and young children
Joseph R DiFranza,corresponding author1 Anthony Masaquel,2 Amy M Barrett,3 Ann D Colosia,3 and Parthiv J Mahadevia2
1Department of Family Medicine and Community Health, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, 01655, USA
2MedImmune, Health Outcomes & Pharmacoeconomics, One MedImmune Way, Gaithersburg, MD, 20878, USA
3RTI Health Solutions, 3040 Cornwallis Road, P.O. Box 12194, Research Triangle Park, NC, 27709-2194, USA
corresponding authorCorresponding author.
Joseph R DiFranza: DiFranza/at/umassmemorial.org; Anthony Masaquel: MasaquelA/at/MedImmune.com; Amy M Barrett: abarrett/at/rti.org; Ann D Colosia: acolosia/at/rti.org; Parthiv J Mahadevia: MahadeviaP/at/MedImmune.com
Received September 21, 2011; Accepted June 21, 2012.
Abstract
Background
The role of environmental tobacco smoke (ETS) exposure as a risk factor for serious respiratory syncytial virus (RSV) disease among infants and young children has not been clearly established. This systematic review was conducted to explore the association between ETS exposure and serious RSV disease in children younger than 5 years, including infants and young children with elevated risk for serious RSV disease.
Methods
A systematic review of English-language studies using the PubMed and EMBASE databases (1990–2009) was performed to retrieve studies that evaluated ETS as a potential risk factor for serious RSV illness. Studies assessing risk factors associated with hospitalization, emergency department visit, or physician visit due to RSV (based on laboratory confirmation of RSV or clinical diagnosis of RSV) in children under the age of 5 years were included.
Results
The literature search identified 30 relevant articles, categorized by laboratory confirmation of RSV infection (n = 14), clinical diagnosis of RSV disease (n = 8), and assessment of RSV disease severity (n = 8). Across these three categories of studies, at least 1 type of ETS exposure was associated with statistically significant increases in risk in multivariate or bivariate analysis, as follows: 12 of 14 studies on risk of hospitalization or ED visit for laboratory-confirmed RSV infection; 6 of 8 studies of RSV disease based on clinical diagnosis; and 5 of the 8 studies assessing severity of RSV as shown by hospitalization rates or degree of hypoxia. Also, 7 of the 30 studies focused on populations of premature infants, and the majority (5 studies) found a significant association between ETS exposure and RSV risk in the multivariate or bivariate analyses.
Conclusion
We found ample evidence that ETS exposure places infants and young children at increased risk of hospitalization for RSV-attributable lower respiratory tract infection and increases the severity of illness among hospitalized children. Additional evidence is needed regarding the association of ETS exposure and outpatient RSV lower respiratory tract illness. Challenges and potential pitfalls of assessing ETS exposure in children are discussed.
Keywords: Respiratory syncytial virus, Respiratory infection, Tobacco, Smoking, Children
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