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BMC Biol. 2012; 10: 66.
Published online 2012 July 31. doi:  10.1186/1741-7007-10-66
PMCID: PMC3409036

Folate status of gut microbiome affects Caenorhabditis elegans lifespan

Abstract

In a paper in BMC Biology Virk et al. show that Caenorhabditis elegans lifespan is extended in response to a diet of folate-deficient Escherichia coli. The deficiencies in folate biosynthesis were due to an aroD mutation, or treatment of E. coli with sulfa drugs, which are mimics of the folate precursor para-aminobenzoic acid. This study suggests that pharmacological manipulation of the gut microbiome folate status may be a viable approach to slow animal aging, and raises questions about folate supplementation.

See research article http://www.http://www.biomedcentral.com/1741-7007/10/67


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