Search tips
Search criteria 


Logo of bmcbiologyBioMed Centralsearchsubmit a manuscriptregisterthis articleBMC Biology
BMC Biol. 2012; 10: 66.
Published online 2012 July 31. doi:  10.1186/1741-7007-10-66
PMCID: PMC3409036

Folate status of gut microbiome affects Caenorhabditis elegans lifespan


In a paper in BMC Biology Virk et al. show that Caenorhabditis elegans lifespan is extended in response to a diet of folate-deficient Escherichia coli. The deficiencies in folate biosynthesis were due to an aroD mutation, or treatment of E. coli with sulfa drugs, which are mimics of the folate precursor para-aminobenzoic acid. This study suggests that pharmacological manipulation of the gut microbiome folate status may be a viable approach to slow animal aging, and raises questions about folate supplementation.

See research article http://www.

Articles from BMC Biology are provided here courtesy of BioMed Central