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Logo of anclinmicBioMed CentralBiomed Central Web Sitesearchsubmit a manuscriptregisterthis articleAnnals of Clinical Microbiology and Antimicrobials
Ann Clin Microbiol Antimicrob. 2012; 11: 13.
Published online May 7, 2012. doi:  10.1186/1476-0711-11-13
PMCID: PMC3408379
Antibacterial activity of statins: a comparative study of Atorvastatin, Simvastatin, and Rosuvastatin
Majed Masadeh,corresponding author1 Nizar Mhaidat,1 Karem Alzoubi,1 Sayer Al-azzam,1 and Ziad Alnasser2
1Faculty of Pharmacy, Jordan University of Science & Technology, Irbid, 22110, Jordan
2Faculty of Medicine, Jordan University of Science & Technology, Irbid, 22110, Jordan
corresponding authorCorresponding author.
Majed Masadeh: mmmasadeh/at/; Nizar Mhaidat: nizarm/at/; Karem Alzoubi: khalzoubi/at/; Sayer Al-azzam: salazzam/at/; Ziad Alnasser: znasser/at/
Received February 19, 2012; Accepted May 7, 2012.
Statins have several effects beyond their well-known antihyperlipidemic activity, which include immunomodulatory, antioxidative and anticoagulant effects. In this study, we have tested the possible antimicrobial activity of statins against a range of standard bacterial strains and bacterial clinical isolates.
Minimum inhibitory concentrations (MIC) values were evaluated and compared among three members of the statins drug (atorvastatin, simvastatin, and rosuvastatin).
It was revealed that statins are able to induce variable degrees of antibacterial activity with atorvastatin, and simvastatin being the more potent than rosuvastatin. Methicillin-sensitive staphylococcus aureus (MSSA), methicillin-resistant staphylococcus aureus (MRSA), vancomycin-susceptible enterococci (VSE), vancomycin-resistant enterococcus (VRE), acinetobacter baumannii, staphylococcus epidermidis, and enterobacter aerogenes, were more sensitive to both atorvastatin, and simvastatin compared to rosuvastatin. On the other hand, escherichia coli, proteus mirabilis, and enterobacter cloacae were more sensitive to atorvastatin compared to both simvastatin and rosuvastatin. Furthermore, most clinical isolates were less sensitive to statins compared to their corresponding standard strains.
Our findings might raise the possibility of a potentially important antibacterial class effect for statins especially, atorvastatin and simvastatin.
Keywords: Antimicrobial activity, Statins, Atorvastatin, Simvastatin, Rosuvastatin
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