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Logo of bttDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressBiologics: Targets and Therapy
 
From:
Published online 2012 July 2. doi: 10.2147/BTT.S20659

Table 4

Biologic monotherapy versus methotrexate: standardized mean difference for total X-ray score

MedicationReferenceFollow-up periodNumber analyzedSMD (95% CI)
TocilizumabNishimoto et al1812 months300−0.43 (−0.65, −0.20)
EtanerceptBathon et al512 months395−0.28 (−0.48, −0.08)
Klareskog et al612 months424−0.24 (−0.43, −0.05)
Pooled−0.26 (−0.40, −0.12)
AdalimumabBreedveld et al1412 months531−0.23 (−0.40, −0.05)
GolimumabEmery et al15
GO-BEFORE15
12 months319−0.02 (−0.24, +0.20)
Emery et al15
GO-FORWARD15
12 months222−0.04 (−0.30, +0.23)
Pooled−0.03 (−0.20, +0.14)

Note: Bold text indicates pooled results for each agent.

Abbreviations: CI, confidence interval; SMD, standardized mean difference.