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Logo of behbrainBioMed CentralBiomed Central Web Sitesearchsubmit a manuscriptregisterthis articleBehavioral and Brain Functions : BBFJournal Front Page
 
Behav Brain Funct. 2012; 8: 4.
Published online Jan 13, 2012. doi:  10.1186/1744-9081-8-4
PMCID: PMC3398286
A novel study on amyloid β peptide 40, 42 and 40/42 ratio in Saudi autistics
Laila Y Al- Ayadhi,1,2,3 Abir G Ben Bacha,2,3,4 Malak Kotb,4,5 and Afaf K El-Ansarycorresponding author2,3,4
1Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia
2Autism Research and Treatment Center, Riyadh, Saudi Arabia
3Shaik AL-Amodi Autism Research Chair, King Saud University, Riyadh, Saudi Arabia
4Biochemistry Department, Science College, King Saud University, Riyadh, Saudi Arabia
5Department of Molecular Genetics, Biochemistry and Microbiology, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA
corresponding authorCorresponding author.
Laila Y Al- Ayadhi: ayadh2/at/gmail.com; Abir G Ben Bacha: aalghanouchi/at/ksu.edu.sa; Malak Kotb: Mkotb/at/cu.edu; Afaf K El-Ansary: elansary/at/ksu.edu.sa
Received June 14, 2011; Accepted January 13, 2012.
Abstract
Objectives
We examined whether plasma concentrations of amyloid beta (Aβ) as protein derivatives play a central role in the etiology of autistic features.
Design and Methods
Concentrations of human Aβ (1-42), Aβ (1-40), and Aβ (40/42) in the plasma of 52 autistic children (aged 3-16 years) and 36 age-matched control subjects were determined by using the ELISA technique and were compared.
Results
Compared to control subjects, autistic children exhibited significantly lower concentrations of both Aβ (1-40) and Aβ (1-42) and lower Aβ (40/42) concentration ratio. Receiver operating characteristics curve (ROC) analysis showed that these measurements of Aβ peptides showed high specificity and sensitivity in distinguishing autistic children from control subjects.
Conclusions
Lower concentrations of Aβ (1-42) and Aβ (1-40) were attributed to loss of Aβ equilibrium between the brain and blood, an imbalance that may lead to failure to draw Aβ from the brain and/or impairment of β- and γ- secretase's concentration or kinetics as enzymes involving in Aβ production.
Keywords: Autism, Neurotoxicity, Amyloid beta, Brain influx, Cognitive disability
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