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Logo of bmjThis ArticleThe BMJ
BMJ. 2012; 345: e3953.
Published online 2012 July 9. doi:  10.1136/bmj.e3953
PMCID: PMC3392078

Lay perspectives on hypertension and drug adherence: systematic review of qualitative research

Iain J Marshall, clinical academic fellow,1 Charles D A Wolfe, professor of public health medicine,1,2 and Christopher McKevitt, reader in social science and health1


Objective To synthesise the findings from individual qualitative studies on patients’ understanding and experiences of hypertension and drug taking; to investigate whether views differ internationally by culture or ethnic group and whether the research could inform interventions to improve adherence.

Design Systematic review and narrative synthesis of qualitative research using the 2006 UK Economic and Social Research Council research methods programme guidance.

Data sources Medline, Embase, the British Nursing Index, Social Policy and Practice, and PsycInfo from inception to October 2011.

Study selection Qualitative interviews or focus groups among people with uncomplicated hypertension (studies principally in people with diabetes, established cardiovascular disease, or pregnancy related hypertension were excluded).

Results 59 papers reporting on 53 qualitative studies were included in the synthesis. These studies came from 16 countries (United States, United Kingdom, Brazil, Sweden, Canada, New Zealand, Denmark, Finland, Ghana, Iran, Israel, Netherlands, South Korea, Spain, Tanzania, and Thailand). A large proportion of participants thought hypertension was principally caused by stress and produced symptoms, particularly headache, dizziness, and sweating. Participants widely intentionally reduced or stopped treatment without consulting their doctor. Participants commonly perceived that their blood pressure improved when symptoms abated or when they were not stressed, and that treatment was not needed at these times. Participants disliked treatment and its side effects and feared addiction. These findings were consistent across countries and ethnic groups. Participants also reported various external factors that prevented adherence, including being unable to find time to take the drugs or to see the doctor; having insufficient money to pay for treatment; the cost of appointments and healthy food; a lack of health insurance; and forgetfulness.

Conclusions Non-adherence to hypertension treatment often resulted from patients’ understanding of the causes and effects of hypertension; particularly relying on the presence of stress or symptoms to determine if blood pressure was raised. These beliefs were remarkably similar across ethnic and geographical groups; calls for culturally specific education for individual ethnic groups may therefore not be justified. To improve adherence, clinicians and educational interventions must better understand and engage with patients’ ideas about causality, experiences of symptoms, and concerns about drug side effects.


Hypertension is a major health problem in both developed and developing countries and is estimated to cause more than 13% of deaths annually.1 Despite national and international guidelines and initiatives for hypertension, population based studies have found that around two thirds of people with hypertension are either untreated or inadequately controlled, including a substantial number who remain undiagnosed.2 3 4

Among those with a diagnosis of hypertension, the World Health Organization has stated that low adherence to treatment is a key factor impeding good control and has called for research into adherence promoting interventions.5 Estimates of the rate of poor adherence or non-adherence to treatment range from 30-50%.6 The causes of poor adherence are complex and include complicated drug regimens, the costs of drugs, older age, poor social support, cognitive problems, and depression.7

In 2005 a study reviewed the qualitative research on drug taking in a wide range of medical conditions and found that patients often actively decided not to take drugs (intentional non-adherence) rather than unintentionally omitting them.8 To date, several patient educational interventions aimed at promoting drug adherence in hypertension have been tested in randomised controlled trials, but most simply informed patients about the importance of adherence and were ineffective.9

A better understanding of patients’ perspectives, through qualitative research, is therefore critical to provide an explanation of the low rates of treatment, adherence, and control and why educational interventions have so far failed, and to inform the development of evidence based interventions to improve management. Indeed, authors of studies of lay epidemiology suggest that clinicians’ failure to recognise how people understand disease causation and risk is one of the key obstacles to the success of public health programmes.10 11 12

We carried out a systematic review and narrative synthesis of qualitative studies on hypertension. Specifically, we examined lay understandings about the causes of hypertension and perspectives on drug taking. We also investigated how patients’ perspectives varied among different cultures and ethnic groups.


We searched electronic databases (Medline, Embase, the British Nursing Index, Social Policy and Practice, and PsycInfo) from inception until October 2011 and hand searched reference lists of relevant papers. The search strategy combined established methodological terms for qualitative research,13 with specific terms for hypertension (see supplementary appendix 1).

Study selection

We included reports of face to face qualitative interviews and focus groups published in peer reviewed journals looking at patient perspectives on hypertension and drug taking; telephone interviews and quantitative questionnaire analyses were excluded. We included studies of people with uncomplicated hypertension and excluded those principally (over 50%) of people with existing cardiovascular disease or diabetes or who were pregnant. Studies were included regardless of quality. One reviewer (IJM) carried out the search and did an initial screen of titles. Clearly irrelevant titles were excluded at this stage. The remaining abstracts were independently considered for inclusion by two reviewers (IJM and CMcK). Disagreements were resolved by discussion. There was no language limitation for inclusion, and translations were obtained for non-English language papers.

Data synthesis and analysis

We carried out a narrative synthesis following the steps recommended by the UK Economic and Social Research Council (ESRC) research methods programme guidance.14 This was developed to encourage systematic and reproducible approaches to narrative synthesis and promotes transparent reporting and the assessment of the robustness of the results. The guidance provides a toolbox of different methods for reviewers. We used textual summary, tabulation, and thematic analysis to synthesise the results.

Developing a theoretical model

The narrative synthesis guidance recommends developing a hypothesis before data are collected.14 We hypothesised that patients’ understanding and experiences of hypertension might contribute to low rates of drug adherence and blood pressure control.

Developing a preliminary synthesis and exploring relations in the data

IJM used a standard template to extract a textual summary of the populations, research question, and results of the included studies; a sample of these was checked by CMcK. Relations in the data were explored through thematic analysis. IJM and CMcK independently extracted and organised emerging themes using the “one sheet of paper” method,15 using the textual summaries and the full text of papers when needed. A final list of themes and the relations between them was agreed by discussion and consensus. The full text papers were then coded according to the presence or absence of themes. We tabulated these codes by country to examine similarities and variation across cultures.

Qualitative research does not permit statistical inferences: the occurrence of a theme in more than one paper does not imply that it is important or common in the population studied. It may, however, provide a greater degree of certainty that the theme is valid, even if in a few people, and therefore we have reported the number of studies where a particular theme was found.

Assessing the robustness of the synthesis

We assessed the quality of the included papers using the checklist by Dixon-Woods and colleagues (box). We used specific criteria for each area to give a score out of 11; one reviewer (IJM) assessed the quality of each paper. The use of quality assessment when reviewing qualitative research has been debated owing to the lack of agreement among researchers about what criteria should be used, the multitude of possible qualitative methods, and the role of subjective judgment in analysis.16 We therefore did not exclude papers with low quality scores but used the scores to provide one indicator of the robustness of the synthesis.

Prompts for appraising qualitative research17

  • Are the research questions clear?
  • Are the research questions suited to qualitative inquiry?
  • Are the following clearly described?
    • Sampling
    • Data collection
    • Analysis
  • Are the following appropriate to the research question?
    • Sampling
    • Data collection
    • Analysis
  • Are the claims made supported by sufficient evidence?
  • Are the data, interpretations, and conclusions clearly integrated?
  • Does the paper make a useful contribution?

We then carried out two sensitivity analyses by reanalysing the data after removing groups of studies thought to be possible sources of bias. Firstly, we examined whether study quality affected the conclusions by assessing the effect of removing lower quality studies (scoring <9 out of 11) from the synthesis. Secondly, to find if the large number of studies in ethnic minority groups had led to unrepresentative conclusions, we carried out a sensitivity analysis only looking at studies that were not in ethnic minority groups.


Overall, 59 papers reporting 53 qualitative studies met the inclusion criteria (figure(figure and table 11).). The studies were from the United States (n=20), the United Kingdom (n=8), Brazil (n=7), Sweden (n=3), Canada (n=2), the Netherlands (n=2), New Zealand (n=2), Denmark (n=1), Finland (n=1), Ghana (n=1), Iran (n=1), Israel (n=1), South Korea (n=1), Spain (n=1), Tanzania (n=1), and Thailand (n=1). Forty studies used one to one qualitative interviews, 11 used focus groups, and two used a mixture of these methods. Twenty four of the 53 studies included people only from ethnic minority groups. Areas covered by study interviews included patients’ understanding of the causes, effects, exacerbating factors, and consequences of hypertension; attitudes towards drugs; and the perceived influences of stress, diet, and racism.

figure mari003757.f1_default
Flow of studies through review
Table 1
 Description of included studies

Narrative synthesis

Causes of hypertension and the role of stress

The main causes of hypertension reported by participants were stress, food, being overweight, family history, and alcohol (table 22).). Participants widely and strongly connected stress and worries with hypertension: as a cause, an exacerbating factor, and a consequence. A participant from a Dutch study seemed to regard worry and blood pressure as synonymous23:

Table 2
 Reported causes of hypertension

It is the burden of my family. BP [blood pressure] is a sort of . . . eh. Actually it doesn’t make a difference how you call it: BP or worrying too much; it seems to be the same thing

Stress from work, unemployment, finances, and family matters were often mentioned as impediments to blood pressure control, both directly and indirectly. Most participants reported that stress led directly to increased blood pressure; but leading a stressful life also caused difficulties in finding time to take drugs, eat well, and attend clinic appointments.

Participants from 10 studies (Brazil, Iran, Sweden, United States, and United Kingdom) described reducing or avoiding stress as a consequence of their diagnosis, such as by relaxing, trying to avoid arguments, and changing jobs.18 32 40 46 52 54 56 57 58 64 68

In three studies (Ghana and United States) a difficult life with previous long term stresses was thought to be responsible for hypertension.24 26 69 African-Americans participants in three US studies and Black Caribbean participants in a UK study thought that the stress of experiencing racism was responsible for their high blood pressure.24 25 26 42 52

A significant stressful event in the past was thought to be responsible for later hypertension by a few participants in four studies (Ghana, Tanzania, United Kingdom, and United States),24 42 69 70 as illustrated by a participant in the UK study:42

I was going through a lot of issues at work and I was going through a lot of issues around race and victimisation I was under extreme stress. So, I went to my doctor and that’s when I was diagnosed with high blood pressure

In seven studies (Canada, Netherlands, Thailand, United States, and United Kingdom) hypertension was seen by some participants as a temporary or curable condition that would not require long term treatment.22 23 28 52 58 60 62

In five studies (Tanzania, United Kingdom, and United States), some participants perceived hypertension to be a distinct condition from high blood pressure,24 40 52 56 70 highlighted by a participant in a US study 40:

My blood just boils, and you don’t know what’s making it happen. You can’t help it. I can’t control it, I’m the kind of person who just can’t keep my mouth shut for nothing. That pertension can hit you at any time. It’s higher and stronger than with pressure. If you have pressure your blood is up, but not as high as with pertension

Most participants understood that hypertension caused serious complications, such as stroke (18 studies: Brazil, Sweden, South Korea, Thailand, United Kingdom, United States), death (13 studies: Brazil, Canada, Denmark, Netherlands, Sweden, United Kingdom, and United States), and heart disease (14 studies: Brazil, Sweden, United Kingdom, and United States). Less widely reported complications included kidney disease (three studies: Brazil, United Kingdom, and United States), paralysis (three studies: Canada and United States), suicide (one study, Brazil), and thinning of the blood (one study, United States). Awareness of possible complications was often a source of fear, as illustrated by a participant in the study from Tanzania70:

I am afraid because I have seen a friend of mine die suddenly. She was overweight and we were living with her in the same house. She woke up in the morning with no problems, ready to leave for work; we talked until the last minute. Suddenly, she fell and died on the spot

Participants in five studies (South Korea, Sweden, United Kingdom, and United States) described that taking drugs reduced anxiety or worries.20 48 51 52 58 This was often thought to be a direct physiological action of drugs20 51 52 but in some cases resulted from feeling protected from the complications of hypertension.48 58 However, participants in two studies (Sweden and United States)51 52 negatively perceived drugs to function as sedatives, as illustrated by a participant in the Swedish study51:

Well, that depends basically—no one kind of medication—some doctors give us like the—oh, sedatives out there to make you relax and go to sleep that you can become addicted to. But other than that, I don’t think it’s much of a dandy, but you have to watch it once you get that sedative type

Symptoms and their meaning

Participants commonly (13 countries, 27 studies) reported symptoms that they connected with hypertension, particularly headache and dizziness (table 33).). Participants in 16 of the studies reported that hypertension caused them no symptoms.

Table 3
 Symptoms most widely associated with hypertension

In 11 studies (Brazil, Denmark, Netherlands, New Zealand, Spain, Thailand, United Kingdom, and United States) a large number of participants used the presence or absence of symptoms to indicate whether their blood pressure was raised,21 22 27 28 32 37 57 58 59 65 72 as illustrated by a participant in the study from Denmark65:

When I got on medication I felt a change for the better in 14 days . . . the headache lifted and I felt 95 percent well . . . and that’s where it’s at. It hasn’t changed since then. It’s not headache, it’s a heaviness which makes you constantly aware of the fact that there is something wrong. It’s like a chunk of lead swimming around inside the head and I can feel in the teeth and in my gums and when I’m sitting quietly in a chair I can feel the pumping pressure

Attitudes to drug taking

Participants in nine studies (Brazil, Netherlands, Thailand, United Kingdom, and United States) reported taking drugs regularly according to the prescription.23 28 32 33 40 56 60 64 73 A belief that drugs were essential is illustrated by a participant in one of the Brazilian studies64:

It is effective if I take it every day, I can’t miss a single day

A participant in one of the US studies described how she planned to ensure she never ran out of tablets33:

I have to make sure I do it like two weeks in advance to make sure I get there . . . I let the medication get to a certain number of pills and then I’ll call them . . . get my medication and there won’t be a break in between me taking it

Intentional non-adherence: link between hypertension, stress, and symptoms

Deliberately choosing to avoid or reduce treatment (intentional non-adherence7) was a theme recurring in many of the studies. People from the Netherlands, the United Kingdom, and the United States (11 studies) reported that symptoms made them more likely to take drugs and lack of symptoms less likely to do so.21 22 27 28 56 58 People from Brazil, Denmark, the Netherlands, Thailand, the United Kingdom, and the United States (10 studies) reported they took drugs exclusively only when symptoms were present.21 22 28 32 37 56 59 58 60 64 65 A participant from the Thai study described how he came to restart treatment after a period of feeling well60:

At that period, I did not visit the doctor because I did not have any symptoms. Then I had symptoms again. I had severe headaches, so I went to a hospital . . . after I took medication, my headaches were gone. I recognised that my high blood pressure had not disappeared

A participant in the Canadian study stopped taking drugs as he preferred instead to control blood pressure by reducing stress62:

I dropped them. I didn’t last long with them. I said to myself, I’ll try to fix my pressure myself. . . . I worked with doctors. They told me that I would end up having to take them but I didn’t want to. . . . I’m not a big pill-taker

Studies from the Netherlands, Sweden, and the United Kingdom, reported that participants perceived that treatment was not needed at times of reduced stress, with one participant reporting that he didn’t take drugs in his home country, where he felt more relaxed.18 22 71 A quote from the Swedish study illustrates this71:

I use my blood pressure pill after how I feel. So when I’m relaxed and not under any stress like in summer when it’s nice weather and vacation, I’ve never taken any blood pressure pills

Intentional non-adherence: dislike of side effects, fear of addiction

People widely reported intentionally missing doses (Canada,62 Netherlands,22 Thailand,60 United Kingdom,56 20 and United States33) or stopping treatment for a time without informing their doctor (Canada,62 Denmark,65 Spain,37 Netherlands,22 Thailand,60 United Kingdom,18 20 28 56 and United States31 33 45 63).

Participants from Spain, the United Kingdom, and the United States experimented with stopping treatment to see how they felt without it.28 37 45 Participants from Brazil, Canada, Spain, the United Kingdom, and the United States reported that they self adjusted their drug dose, often because of a desire to avoid side effects or a perception that their blood pressure was controlled.20 32 33 37 56 57 62 A few participants in two studies (United Kingdom and United States) omitted treatment when using alcohol or recreational drugs owing to fear of a harmful interaction.56 57 63

Participants from Canada, Thailand, the United Kingdom, and the United States (in 10 studies) reported a fear of long term problems from taking drugs.18 20 33 51 52 56 57 59 60 62 73 These were described as a “build up” of drugs in the body or developing a tolerance or addiction to the drugs. A participant from a UK study described his reluctance to take drugs57:

I prefer to let nature take its course as far as my body is concerned. I’m not one to introduce anything to it if I’m feeling alright. If I’m feeling ill I will take any medication that will make me better or even cure me, but if I feel better I don’t see why I should take it, because I don’t want to be addicted to nothing other than food and water

Other adverse effects were often reported, such as ankle swelling, lethargy, and urinary frequency. Impotence was mentioned widely by men as a troublesome side effect of treatment (Netherlands, Thailand, United Kingdom, and United States).20 22 31 56 57 59 60 73

Intentional non-adherence: alternative medicines

Participants from six countries (12 studies) reported supplementing or replacing drugs with a wide range of traditional and alternative medicines (table 44).). Traditional treatments were widely perceived to be safer and more natural than drugs.

Table 4
 Non-drug treatments reported

Non-intentional non-adherence

Participants described various external factors that limited their ability to adhere to treatment (non-intentional non-adherence7). Participants commonly forgot to take drugs from time to time in studies from Canada, South Korea, Spain, the United Kingdom, and the United States (10 studies in total).31 34 37 39 45 48 62 63 73 Participants in eight studies (New Zealand, South Korea, and United States) reported that other commitments meant that they were too busy to take drugs or to attend medical appointments.31 34 39 48 49 59 63 74 Participants from two Brazilian studies and seven of the US studies reported that hypertension care was too expensive: the costs of drugs, healthy food, and visiting doctors were all reported as barriers.32 33 34 39 40 44 59 63 64 76 Participants in three of the US studies reported that not having health insurance hindered them from accessing medical care.32 39 63

Robustness of findings

The studies were generally of high quality (mean quality score 9.8 out of 11). Sensitivity analyses were done for the key themes (connecting hypertension with stress, having symptoms, using symptoms to judge blood pressure levels, taking drugs only when symptoms were present). These showed that the principal results were robust when limiting the analysis to the highest quality studies (excluding those scoring <9 out of 11 for quality), studies not carried out in an ethnic minority group, and studies done outside the United States (table 55).

Table 5
 Examples of sensitivity analyses


In this systematic review on people’s perspectives on hypertension and drug taking, many participants in the individual studies perceived stress to be the primary cause and exacerbating factor of hypertension. They widely described symptoms they perceived to be caused by hypertension, particularly headache, palpitations, and dizziness. Contrary to the conclusions of individual studies, these symptoms were consistent among different ethnic and geographical groups. Notably, these symptoms are also commonly reported as being caused by anxiety in the biomedical literature.77

Participants intentionally adjusted their drug dose, took drugs sporadically, and stopped altogether, often without consulting their doctor. Reasons given for reducing treatment included a perception that blood pressure had improved because of a reduction in symptoms, that drugs were unnecessary when under less stress, a dislike of taking drugs, a fear of addiction or tolerance, and side effects.

Comparison with other research on health understanding

A systematic review in 2005 included 37 qualitative studies looking at drug taking in any medical condition (including four hypertension studies also reported in this review).8 That review also found that drugs were seen as undesirable and that many participants feared dependence and tolerance. Participants often tested new drugs for a time to check for adverse effects and whether symptoms were reduced. Our review provides confirmatory evidence from a larger number of studies that these themes are important in hypertension and adds further themes important in hypertension specifically, particularly around stress and symptoms.

Quantitative research provides some evidence that the themes presented here are widespread. A UK study found that 43% of people used complementary medicine to treat hypertension.78 Two US studies found that most participants had symptoms they believed to be caused by hypertension (71-94% in the first study, 70% in the second study).79 80

Comparison with biomedical model

Stress and symptoms

The nature of the connection between hypertension and stress has been researched extensively. Acute stress has been shown to temporarily increase blood pressure levels.81 Evidence from observational studies has also shown that chronic stress can be associated with a sustained rise in high blood pressure.82 In the medical literature, however, stress is considered in the context of other important risk factors for hypertension, both modifiable and non-modifiable: age, ethnicity, family history, obesity, a sedentary lifestyle, and alcohol and salt intake.1 While participants in our review widely reported avoiding stressful situations, a meta-analysis of randomised controlled trials of relaxation interventions for people with hypertension found that they did not substantially improve blood pressure levels, nor did the trials find good evidence of an effect on cardiovascular disease or mortality.83 From the medical perspective, stress plays a small part in hypertension, whereas a recurring theme in the studies presented here was that stress was by far the most important cause.

Likewise, the biomedical literature suggests that symptoms are more likely to be connected with anxiety and stress than blood pressure itself. Although people with hypertension in observational studies have been found to report symptoms, these studies also found that symptoms did not coincide with periods of raised blood pressure when measured clinically.84 85 It was also found that these symptoms were significantly more likely in anxious people. A larger study in the general population found the same association with nervousness, but also found no link with periods of high blood pressure.86

Benefits and adverse effects

Side effects were a widely reported reason for self adjusting or stopping drugs. Participants in these studies described a range of adverse effects of treatment, many of which are listed in the medical literature, including leg swelling, urinary frequency, fatigue, and impotence.87 88 89 Other longer term fears about the drugs, such as the perception of addiction “building up” over time, or acting as sedatives, are not present in the medical literature. A fear of addiction is not exclusive to hypertension: qualitative studies have found that participants with other chronic medical problems reported identical views.8 Conversely, participants in several studies in this review reported seeing treatment as essential, stating they would not contemplate missing even a single day. The responses from some participants suggest they thought that treatment abolished any risk of cardiovascular disease.33 The benefit assumed by these participants is much greater than the small absolute reductions in risk found in clinical trials.90

Overlap with biomedical model

Rather than being entirely separate, participants’ understandings of hypertension overlapped with many aspects of the biomedical model. Aside from the universally strong emphasis placed on stress, the causes and consequences of hypertension reported by participants are identical to those in any medical textbook. The largest included study examined this contradiction in more depth.24 In this study individual participants often held mutually contradictory explanations, and the inconsistencies did not trouble them.

Similarities among cultural, ethnic, and geographical groups

Previous studies have examined the health beliefs of specific ethnic groups; in particular, many have been done in African-American people, to explore cultural factors influencing low rates of hypertension control.91 The authors of many of the studies in this review concluded that specific culturally appropriate education is needed, implying that their findings were unique in the particular population studied. However, the principal themes identified here were remarkably similar across geographical and ethnic groups. Participants in most of the studies perceived hypertension as a symptomatic illness associated principally with stress; this was confirmed in the sensitivity analyses looking at studies that were not restricted to minority ethnic groups, and in the non-US studies.

Differences between cultural, ethnic, and geographical groups

Racism was often reported by participants from minority ethnic groups. In several studies from the United States of African Americans and one of Filipino-Americans and one study of people of black Caribbean ethnicity in the United Kingdom, the stress caused by racism was reported to exacerbate hypertension. Migrant populations also perceived that they were more likely to have low paying jobs and experience greater economic hardship. African-American participants from two US studies reported a lack of trust of their white doctors, perceiving prejudice against them.

A UK study that compared the reports from black Caribbean and white British participants found that a large number of black Caribbean participants reported self adjusting and stopping drugs, whereas all but one white British participant reported taking drugs regularly. Although a traditional diet was mentioned as an exacerbating factor for hypertension in many studies, this did not seem to be unique to any particular group. A Dutch study found that people of Surinamese, Ghanaian, and white European ethnicity equally thought that their traditional diet worsened their blood pressure.22

Implications for clinicians and hypertension education

The evidence presented here adds weight to the criticism of educational interventions that assume poor adherence is due to patients’ failings, either in knowledge or remembering to take drugs.92 The participants in the studies presented here did not simply have a knowledge deficit but held alternative explanations for their hypertension; many deliberately chose to avoid drugs.

This may explain why educational interventions that simply inform about the conventional medical view have proved ineffective.9 To better deal with these problems, clinicians and educational interventions must acknowledge and incorporate patients’ concerns and perspectives. Specifically, patients should be given an honest and accurate representation of the likelihood of benefit and adverse effects with treatment. The evidence of safety of long term use of drugs should be discussed, including that treatment is not thought to “build up” in the body or to cause a physical dependence. Fears about addiction could be further tackled by informing patients that they are unlikely to experience adverse effects if they decide to stop, no matter how long they have taken the treatment. This is in stark contrast to existing educational interventions, which emphasise the importance of continuous tablet taking.9

Rather than denying the possibility of symptoms, patients’ experiences should be acknowledged. Patients could be informed that people with hypertension often report symptoms but that they have not been found to be a reliable indication of fluctuations in blood pressure levels. Patients could be informed that their risk of cardiovascular disease is increased regardless of whether they have symptoms, and that treatment can effectively prevent cardiovascular disease.

Stress should be placed in the context of other modifiable and non-modifiable risk factors for hypertension and cardiovascular disease; it should be noted that relieving stress alone is not likely to normalise blood pressure and that treatment is recommended at times of high and low stress.

Non-intentional factors, such as forgetting and being busy, were mentioned by many participants as reasons for not taking drugs, and there is low quality evidence from randomised controlled trials that reminder interventions may have an effect.9 However, the qualitative research suggests that reminders alone that neglect patients’ health understanding are not likely to provide a highly effective solution.

Finally, we did not find strong evidence that educational interventions for hypertension need to be tailored to a particular cultural or ethnic group; the consistency of the results presented here suggests that it is more important to take account of common understandings and experiences across the world.

Strengths and weaknesses of the review

This study used a systematic strategy for identifying, reporting, and synthesising qualitative research. Several features suggest that the results are robust. Firstly, we identified a large number of studies, which were largely judged to be of high quality. Secondly, many of the themes we identified were reported repeatedly in a large number of papers. These themes did not vary substantially across different countries. Thirdly, the results of sensitivity analyses, when we removed the groups of papers thought possible to cause bias, did not change the conclusions of the main analysis.

We chose to use the Economic and Social Research Council guidance on narrative synthesis as it both encourages transparent reporting and places a strong emphasis on assessing the robustness of results; the lack of both has been a criticism of other methods of synthesising qualitative research.93 Although no formal test of different synthesis methods versus each other exists,93 the strong evidence of themes found here and the large degree of overlap between narrative synthesis and other qualitative synthesis methodologies suggest that other methods would have produced similar results.

We made a pragmatic decision to include studies from peer reviewed journals only, to retrieve the highest quality research. It seems likely that a body of qualitative research also exists in book chapters, university theses, and conference presentations, that was not included in this review. Although we used no language restriction for inclusion of studies and included some non-English language papers, we would have missed those not listed on English language databases.

Certain groups in the research were represented disproportionately: nearly half of the studies looked at an ethnic minority population and nearly half were done in the United States. Although this presented a potential source of bias, the themes in these papers did not differ substantially from those from other countries and from studies without restriction to an ethnic group.

Implications for research

This review examined the importance of patients’ health understanding for one aspect of cardiovascular disease prevention. Syntheses of the qualitative research on other cardiovascular risk factors would complement the findings and could help inform the development of new interventions. Carrying out a systematic review when planning new qualitative research may help to avoid the unintentional examination of questions that have already been extensively researched. Finally, when developing future educational interventions, it may be more rewarding for researchers to consider shared explanations for hypertension rather than attempting to target a specific ethnic or cultural group.

Implications for practice

Lay perspectives about hypertension are often different from the medical viewpoint: worldwide, people widely perceive that hypertension is principally a stress related condition with symptoms and fear addiction or dependence on drugs. These commonly caused people to reduce or stop treatment. If they are to be successful at improving adherence, future educational interventions must incorporate and engage with these widespread perspectives and experiences rather than simply reiterating the biomedical view. A greater understanding between doctors and their patients must play a part in future strategies for reducing cardiovascular disease.

What is already known on this topic

  • Between 30% and 50% of people with hypertension do not take drugs regularly
  • Qualitative research in other chronic conditions showed that patients often actively decide to avoid drugs rather than unintentionally missing them
  • Qualitative studies have focused on the health beliefs of specific ethnic groups in hypertension, suggesting that cultural factors contribute to low rates of control

What this study adds

  • People with hypertension interviewed in qualitative studies often relied on the presence of stress or symptoms to determine whether their blood pressure was raised
  • This perceived connection led many to reduce or stop drugs in response to fewer symptoms or less stress
  • There seem to be few major differences in understanding of hypertension between people from different ethnic groups and countries—calls for culturally specific education by the authors of qualitative studies may not be justified

Web Extra. Extra material supplied by the author

Web ExtraExtra material supplied by the author


We thank Bom Lee for translating a paper into English and the authors of the original studies who provided copies of their papers.

Contributors: IJM carried out the search, appraised the papers for inclusion, extracted and analysed the data, and drafted the paper. CMcK appraised the papers for inclusion, analysed the data, and critically revised the drafts and the final report. CDAW advised about the study design and methods and critically revised the drafts and the final report. CMcK is guarantor.

Funding: This study is the independent work of the authors.

Competing interests: All authors have completed the ICMJE uniform disclosure form at (available on request from the corresponding author) and declare: IJM was employed as a clinical editor for Clinical Evidence at BMJ Group from 2008 to March 2010; no other financial relationships with any organisations that might have an interest in the submitted work in the previous three years; no other relationships or activities that could appear to have influenced the submitted work. This article presents independent research commissioned by the National Institute for Health Research under its programme grants for applied research funding scheme (RP-PG-0407-10184). The views expressed in this article are those of the authors and not necessarily those of the National Health Service, the National Institute for Health Research, or the Department of Health.

Ethical approval: Not required.

Data sharing: No additional data available.


Cite this as: BMJ 2012;344:e3953


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