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Logo of bmcmicrBioMed Centralsearchsubmit a manuscriptregisterthis articleBMC Microbiology
 
BMC Microbiol. 2012; 12: 40.
Published online Mar 22, 2012. doi:  10.1186/1471-2180-12-40
PMCID: PMC3391984
Antagonistic interactions peak at intermediate genetic distance in clinical and laboratory strains of Pseudomonas aeruginosa
Sijmen E Schoustra,corresponding author1,2 Jonathan Dench,1 Rola Dali,1 Shawn D Aaron,3 and Rees Kassen1
1Biology Department, University of Ottawa, 30 Marie Curie, Ottawa, ON K1N 6N5, Canada
2Laboratory of Genetics, Wageningen University, Droevendaalsesteeg 1, 6708 PB Wageningen, the Netherlands
3Ottawa Health Research Institute, 725 Parkdale Ave, Ottawa, ON K1Y 4E9, Canada
corresponding authorCorresponding author.
Sijmen E Schoustra: Sijmen.Schoustra/at/wur.nl; Jonathan Dench: jdenc017/at/gmail.com; Rola Dali: rdali094/at/uottawa.ca; Shawn D Aaron: saaron/at/ohri.ca; Rees Kassen: rkassen/at/uottawa.ca
Received June 22, 2011; Accepted March 22, 2012.
Abstract
Background
Bacteria excrete costly toxins to defend their ecological niche. The evolution of such antagonistic interactions between individuals is expected to depend on both the social environment and the strength of resource competition. Antagonism is expected to be weak among highly similar genotypes because most individuals are immune to antagonistic agents and among dissimilar genotypes because these are unlikely to be competing for the same resources and antagonism should not yield much benefit. The strength of antagonism is therefore expected to peak at intermediate genetic distance.
Results
We studied the ability of laboratory strains of Pseudomonas aeruginosa to prevent growth of 55 different clinical P. aeruginosa isolates derived from cystic fibrosis patients. Genetic distance was determined using genetic fingerprints. We found that the strength of antagonism was maximal among genotypes of intermediate genetic distance and we show that genetic distance and resource use are linked.
Conclusions
Our results suggest that the importance of social interactions like antagonism may be modulated by the strength of resource competition.
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