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Mol Biol Cell. Jul 1, 2012; 23(13): 2402.
PMCID: PMC3386203
An MBoC Favorite: Functional interactions between sphingolipids and sterols in biological membranes regulating cell physiology
Jean Gruenberg*
Department of Biochemistry, University of Geneva, CH-1211 Geneva, Switzerland
*Address correspondence to: Jean Gruenberg (jean.gruenberg/at/unige.ch).
In celebration of MBoC's first 20 years, members of the Editorial Board, members of the ASCB Council, and others comment on their favorite MBoC papers from the past two decades.
Over the past few decades, sphingolipids and sterols have been in the news frequently. They were spotted together on many occasions, but their relationship seemed to be going through a roller-coaster ride, with many ups and downs. Guan et al. (2009) blue right-pointing triangle carried out a systematic lipidomics analysis combined with genetics, which revealed that the affair between these lipids is a stable, long-term romance. These studies show that yeast cells adjust their membrane composition in response to changes in sterol structures, preferentially by changing their sphingolipid composition, demonstrating that sterols and sphingolipids function together in cells.
Footnotes
DOI: 10.1091/mbc.E12-03-0190
Molecular Biology of the Cell Volume 23 Page 2402.
REFERENCE
  • Guan XL, et al. Functional interactions between sphingolipids and sterols in biological membranes regulating cell physiology. Mol Biol Cell. 2009;20:2083–2095. [PMC free article] [PubMed]
Articles from Molecular Biology of the Cell are provided here courtesy of
American Society for Cell Biology