Myopericytoma is an uncommon tumor, so reports of myopericytoma are very rare and therefore surgeons and pathologists have difficulty readily making a diagnosis. Myopericytoma is generally considered a slow-growing benign tumor and the diameter is usually less than 2 cm. It occurs predominantly in the skin and superficial soft tissue of the distal extremities, followed by the head and neck region, and the trunk. It could be located multifocally in an anatomic area. It occurs very rarely in the different organs of the head and neck region with multiple large features. The tumor may recur locally and its recurrence is noted in rare cases [4
Myopericytoma was recently characterized as a soft-tissue neoplasm with perivascular differentiation of myoid cells. Dictor et al. [6
] described the term myopericyte by a case of hemangiopericytoma with a myofibromatous pattern. It represents a transitional form between pericytes and the smooth muscle cells of vessels. Microscopic examination of a benign myopericytoma with hematoxylin-eosin-staining is characterized by collagenous fibrous capsulation and the presence of cells arranged inside concentric islands. The tumor is also characterized by the presence of surrounding numerous small to medium-sized vessels with a concentric perivascular arrangement of neoplastic cells, presenting even brand of cell and exhibited ovoid nuclei, even distributed chromatin, and distinct nucleoli with abundant eosinophilic cytoplasm [3
The neoplastic cells exhibited strong and diffuse immunoreactivity for muscle specific actin, smooth muscle actin (SMA), CD34, and bcl-2, whereas the tumor was negative for keratin, epithelial membrane antigen, desmin, S-100 protein, human melanoma black-45, Melan-A, CD31, chromogranin, and synaptophysin [1
A diagnosis of myopericytoma was established along the immunohistochemical pattern with the histopathological findings. A contrast-enhanced computed tomography (CT) examination is thought to be helpful for evaluation and in the differential diagnosis for myopericytoma. Peripheral enhancement, irregular central non-enhanced attenuation masses with unsmoothed margins and single or multiple slow-growing reactive lymph nodes are the CT features of myopericytoma, but they are nonspecific [7
Myopericytoma of the parotid gland should be distinguished from hemangiopericytoma and myoepithelioma because these benign tumors are similar in histological features and occur rarely in the parotid gland.
Hemangiopericytoma has a perivascular arrangement of ovoid cells with expression of myogenic markers, but it is characterized by staghorn-shaped spaces with an intervening proliferation of cells and rarely, it may show immunoreactivity to SMA and consistent positivity for CD34 staining [5
Myoepithelioma shows nonspecific histopathologic features but its most common variant is the spindle cell type. It is characterized by myoepithelial cells, contains few ducts, and may show strongly positive for calponin and S-100 protein but not for vimentin, cytokeratins, or SMA [8
Patients with benign myopericytomas are usually treated with complete surgical excision. In the parotid gland myopericytoma specifically, the superficial parotidectomy with facial nerve preservation is known as a treatment of choice [9
]. The prognosis of this entity is good. In benign cases, local recurrence occurs rarely. A malignant myopericytoma is extremely rare, often with local recurrence and distant metastases in other organs or extensive metastases, and the metastasizing neoplasm is associated with the depth of the neoplasm [3
]. In this case, the lesion occurred locally in the multifocal region, but it is not clear whether the tumor that occurred in the parotid gland is a recurrent one or not. It was probably due to an incomplete excision of the tumor or the characteristic multifocal feature. Over the 4 year follow-up period, there was no evidence of recurrence.
As many perivascular myoid neoplasms share common morphologic features with myopericytoma, we should consider the differential diagnosis, and confirm the histological findings with appropriate immunohistochemical staining. After identifying myopericytoma, it should be treated with wide surgical excision to prevent local recurrence.