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Logo of bmccancBioMed Centralsearchsubmit a manuscriptregisterthis articleBMC Cancer
 
BMC Cancer. 2012; 12: 102.
Published online 2012 March 21. doi:  10.1186/1471-2407-12-102
PMCID: PMC3384469
Copyright ©2012 Xue et al; licensee BioMed Central Ltd.
Interleukin-10-819 promoter polymorphism in association with gastric cancer risk
Huiping Xue,corresponding author#1,2 Bing Lin,#3 Jianfu An,#4 Yuyuan Zhu,#5 and Gang Huangcorresponding author5
1Division of Gastroenterology and Hepatology, Shanghai Jiaotong University School of Medicine Renji Hospital, Shanghai Institution of Digestive Disease, Shanghai, People's Republic of China
2Key Laboratory of Gastroenterology & Hepatology, Ministry of Health(Shanghai Jiaotong University), Shanghai, People's Republic of China
3Division of Nutrition, Zhongshan Hospital, Fudan University School of Medicine, Shanghai, People's Republic of China
4Division of Bioinformatics, Shanghai Jiaotong University School of Medicine,, Shanghai, People's Republic of China
5Department of Nuclear Medicine, Shanghai Jiaotong University School of Medicine Renji Hospital, Shanghai, People's Republic of China
corresponding authorCorresponding author.
#Contributed equally.
Huiping Xue: xue_huiping/at/126.com; Bing Lin: lin_bing/at/msn.com; Jianfu An: anjianfu/at/163.com; Yuyuan Zhu: hezicase/at/gmail.com; Gang Huang: huanggang_sjumed/at/163.com
Received October 24, 2011; Accepted March 21, 2012.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Abstract
Background
Potential functional allele T/C single nucleotide polymorphism (SNP) of Interleukin 10 (IL-10) promoter -819 (rs1800871) has been implicated in gastric cancer risk. We aimed to explore the role of T/C SNP of IL-10 -819 in the susceptibility to gastric cancer through a systematic review and meta-analysis.
Methods
Each initially included article was scored for quality appraisal. Desirable data were extracted and registered into databases. 11 studies were ultimately eligible for the meta-analysis of IL-10 -819 T/C SNP. We adopted the most probably appropriate genetic model (recessive model). Potential sources of heterogeneity were sought out via subgroup and sensitivity analyses, and publication biases were estimated.
Results
IL-10 -819 TT genotype is associated with the overall reduced gastric cancer risk among Asians and even apparently observed among high quality subgroup Asians. IL-10-819 TT genotype is not statistically associated with the overall reduced gastric cancer susceptibility in persons with H. pylori infection compared with controls without H. pylori infection. IL-10 -819 TT genotype is reversely associated with diffuse-subtype risk but not in intestinal-subtype risk. IL-10 -819 TT genotype is not reversely associated with non-cardia or cardia subtype gastric cancer susceptibility.
Conclusions
IL-10 -819 TT genotype seems to be more protective from gastric cancer in Asians. Whether IL-10 -819 TT genotype may be protective from gastric cancer susceptibility in persons infected with H. pylori or in diffuse-subtype cancer needs further exploring in the future well-designed high quality studies among different ethnicity populations. Direct sequencing should be more used in the future.
Keywords: Interleukin 10, Gene, Single nucleotide polymorphism, Association, Gastric cancer
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