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Logo of bmcbiologyBioMed Centralsearchsubmit a manuscriptregisterthis articleBMC Biology
 
BMC Biol. 2012; 10: 58.
Published online Jun 26, 2012. doi:  10.1186/1741-7007-10-58
PMCID: PMC3383472
RNAi in the regulation of mammalian viral infections
Kuan-Teh Jeangcorresponding author1
1The National Institutes of Health, Bethesda, MD 20892-0460, USA
corresponding authorCorresponding author.
Kuan-Teh Jeang: KJEANG/at/niaid.nih.gov
Received April 10, 2012; Accepted June 22, 2012.
Abstract
Although RNA interference (RNAi) is known to play an important part in defense against viruses of invertebrates, its contribution to mammalian anti-viral defense has been a matter of dispute. This is surprising because all components of the RNAi machinery necessary for robust RNAi-mediated restriction of viruses are conserved in mammals, and the introduction of synthetic small interfering RNAs (siRNAs) into cells efficiently silences the replication of viruses that contain siRNA complementary sequences in those cells. Here, I discuss the reasons for the dispute, and review the evidence that RNAi is a part of the physiological defense of mammalian cells against viral infections.
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