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|0 mg/kg||9 ± 2 mg/kg||18 ± 4 mg/kg|
|upset stomach||—||d1, h1||d1|
|stomach or intestinal gas||d1||d1||d1, i1|
Note. Lowercase letters (d, h, i) refer to individual subjects from Arm 1. Superscripts show ranked intensity of adverse reaction reported by each subject. Ranked intensities are (1) mild, (2) moderate, and (3) severe. Subjects who indicated “none” (0) for an adverse reaction are omitted for clarity. None of the subjects experienced light-headedness; redness of eyes, face, or hands; welts; or wheezing. Dashes indicate that none of the subjects reported the adverse reaction listed. Subjects received placebo or 600 or 1,200 mg of N-acetylcysteine capsules. Doses are shown normalized for body weight.