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Emerg Infect Dis. Feb 2006; 12(2): 304–306.
PMCID: PMC3373114
Rotavirus and Severe Childhood Diarrhea
Umesh D. Parashar,corresponding author* Christopher J. Gibson,* Joseph S. Bresee,* and Roger I. Glass*
*Centers for Disease Control and Prevention, Atlanta, Georgia, USA
corresponding authorCorresponding author.
Address for correspondence: Umesh D. Parashar, Viral Gastroenteritis Section, Respiratory and Enteric Viruses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Mailstop G-04, 1600 Clifton Road, NE, Atlanta, GA 30333, USA: fax: 404-639-3645; email: uap2/at/cdc.gov
Abstract
Studies published between 1986 and 1999 indicated that rotavirus causes ≈22% (range 17%–28%) of childhood diarrhea hospitalizations. From 2000 to 2004, this proportion increased to 39% (range 29%–45%). Application of this proportion to the recent World Health Organization estimates of diarrhea-related childhood deaths gave an estimated 611,000 (range 454,000–705,000) rotavirus-related deaths.
Keywords: Diarrhea, rotavirus, mortality, morbidity, hospitalizations, disease burden, dispatch
Rotavirus is the leading cause of diarrhea hospitalization among children worldwide (1). In 2003, we published an estimate of rotavirus-related deaths worldwide based on a review of the literature published from 1986 through 1999 on deaths caused by diarrhea and rotavirus hospitalizations in children (2). This review indicated that rotavirus accounted for ≈22% of hospitalizations for childhood diarrhea. By applying this fraction to an estimate of 2.1 million annual deaths from diarrhea, we calculated that rotavirus causes 440,000 annual deaths in children <5 years of age worldwide. This estimate was ≈50% of the 1985 estimate of 873,000 rotavirus deaths per year (3), and the decrease in estimated rotavirus-related deaths paralleled the decrease in deaths from diarrhea of all causes from an estimated 4.6 million deaths in 1982 to 1.6–2.5 million deaths in 2000 (46).
Recent studies suggest that as global deaths from childhood diarrhea decreased during the past 2 decades, the proportion of diarrhea hospitalizations attributable to rotavirus may have increased. For example, prospective, sentinel hospital–based surveillance of rotavirus disease in 9 Asian countries demonstrated a median rotavirus detection of 45% among children hospitalized with diarrhea (7), a figure that was considerably greater than the detection rates in previous studies from the same countries. Similarly, a more extensive study of 5,768 children hospitalized from 1998 through 2000 in 6 centers in Vietnam identified rotavirus in 56% of patients (8), a proportion that was more than twice the 21% detection rate reported among children hospitalized with diarrhea in a hospital in Hanoi, Vietnam, from 1981 to 1984 (9).
To systematically evaluate whether these recent reports are isolated observations or reflect a changing trend in the etiology of childhood diarrhea hospitalizations, we reviewed studies of rotavirus detection among children hospitalized with diarrhea published from 2000 through 2004 and compared the data with those of the previous review of studies published from 1986 through 1999.
Similar to the approach used in our previous review, we performed a computer search of the scientific literature (in English and other languages) published from January 2000 through June 2004 using the words rotavirus and the truncated stem rota-. We restricted the analysis to studies that met the following criteria: 1) were initiated after 1993; 2) were conducted for at least 1 full calendar year; and 3) examined rotavirus among at least 100 children <5 years of age hospitalized with diarrhea.
For each study, we determined the proportion of cases positive for rotavirus among children hospitalized with diarrhea. We plotted this proportion against the per capita gross national product (GNP) for the country in which the study was conducted. We then classified countries by per capita GNP into World Bank income groups (low, <US $756; low-middle, US $756–$2,995; high-middle, US $2,996–$9,265; and high, >US $9,265) (10), and calculated the median (interquartile range [IQR]) proportion of diarrhea hospitalizations attributable to rotavirus for each income group.
We next calculated an overall median detection rate by taking a weighted average of the median detection rates for each of the income groups. The weights assigned to each income group corresponded to the proportion of deaths from childhood diarrhea among countries in that income group as determined on the basis of our previous analysis (2): 85% in low-income countries, 13% in low-middle–income countries, 2% in high-middle–income countries, and <1% in high-income countries. To estimate deaths from rotavirus disease among children, we multiplied the overall median detection rate of rotavirus among children hospitalized with diarrhea by a recent World Health Organization estimate of deaths from diarrhea among children worldwide (5).
We abstracted information from 41 studies that met all the inclusion criteria (Table A1). Unlike the previous review of studies conducted for the period 1986–1999, in which the proportion of diarrhea-related hospitalizations attributable to rotavirus showed a distinct increasing trend with increasing income level, we found that the median detection rates increased only slightly with increasing income level (Figure 1). The median detection rate for rotavirus among children hospitalized with diarrhea was 39% in studies conducted in low-income countries, 40% for low-middle–income countries, 38% for high-middle–income countries, and 44% for high-income countries, for an overall weighted median estimate of 39% (Table).
Figure 1
Figure 1
Percentage of severe diarrhea cases attributable to rotavirus for countries in different World Bank income groups, by per capita gross national product (GNP), for studies published in 1986–1999 and 2000–2004. GNP is in US dollars. Upper (more ...)
Table
Table
Percentage of diarrhea hospitalizations attributable to rotavirus for countries in different World Bank income groups, 1986–1999 and 2000–2004
If we multiply the greater median rotavirus detection rate of 39% (IQR 29%–45%) from this analysis by 1,566,000 recently estimated childhood diarrhea deaths (5), we find that rotavirus causes ≈611,000 childhood deaths (IQR 454,000–705,000). More than 80% of all rotavirus-related deaths were estimated to occur in low-income countries of south Asia and sub-Saharan Africa (Figure 2).
Figure 2
Figure 2
Estimated global distribution of rotavirus-related deaths. Each dot represents 1,000 rotavirus-related deaths.
Compared with results from studies published from 1986 to 1999, the proportion of diarrhea hospitalizations attributable to rotavirus appears to have increased between 2000 and 2004. This phenomenon likely reflects a relatively slower rate of decrease in hospitalizations for rotavirus compared with other causes of severe childhood diarrhea. This finding could be accounted for by several factors. First, interventions to improve hygiene and sanitation are likely to have a greater impact on diarrhea caused by bacterial and parasitic agents, which are transmitted primarily through contaminated food or water, unlike rotavirus, which is often spread from person-to-person. This hypothesis is supported by data from the United States (11) and Mexico (12), which showed that as diarrhea-related childhood deaths decreased dramatically in both countries; the decrease was greatest during the summer months when diarrheal diseases caused by bacteria are more prevalent. In both countries, diarrhea-related deaths in recent years have exhibited peaks only in the winter when rotavirus infections are common. Second, oral hydration therapy to replace loss of body fluids, which many regard as a major factor responsible for the decrease in diarrhea deaths (13), is often more difficult to successfully administer in children with severe vomiting (14), a common manifestation of rotavirus disease. Third, unlike antimicrobial therapies that are effective against some bacterial and parasitic agents, no specific treatment for rotavirus infection is available.
We have derived preliminary updated estimates of rotavirus-related childhood deaths on the basis of the findings of our review. Because we wanted to assess the most recent trends in rotavirus incidence, we examined a relatively limited number of studies published in the last 5 years, particularly from upper-middle– and high-income countries. However, these 2 income groups account for only a small fraction (<5%) of all deaths from rotavirus disease, and the 28 studies available from low- and low-middle–income countries allowed for a reasonably robust analysis. Nevertheless, our findings should be updated as new data on rotavirus hospitalizations and updated estimates of childhood diarrhea deaths become available. In 2002, the World Health Organization published a generic protocol for hospital-based surveillance of rotavirus (15), and studies using this protocol are currently being conducted or planned in >30 countries in Asia, Africa, the Middle East, and Latin America. Data from these and other studies, particularly from countries such as India and China, which account for a large fraction of global rotavirus deaths, should be used to update our estimate of rotavirus-related deaths and further refine it to develop country-specific figures. These data, together with information on effects and costs of rotavirus disease, will allow policymakers to assess the magnitude of the problem of rotavirus and the value of new vaccines that may soon be available.
References
Biography
Dr Parashar is a medical epidemiologist with the Respiratory and Enteric Viruses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention. His research focuses on the epidemiology of viral gastroenteritis and respiratory infections and methods for their prevention and control.
 
Table A1
Characteristics of studies on worldwide diarrheal deaths and hospitalizations, 2000–2004
Income group and countryYear of publicationStudy periodNo. diarrhea hospitalizationsRotavirus detection rate (%)Reference
Low
Cameroon20031999–200089021.916
Côte d'Ivoire20031997–199947928.317
Ghana20031997–20022,20540.518
Ghana20031998–20001,71739.419
India2004200140135.520
India20011993–199662828.321
India20031999–200020223.322
Indonesia20042001–200257752.023
Indonesia20021997–199933944.824
Nigeria20031998–199941738.617
Vietnam20042001–20021,57059.023
Vietnam20031999–20001,35565.625
Zambia20031997–19991,63523.317
Low-middle
Bosnia-Herzegovina20031999–200020123.926
Brazil20011998–199919032.627
China20042001–20022,07944.023
China20001996–19991,13026.128
China20021998–20003,17741.029
China20031998–20011,21152.930
China20041999–20011,23040.131
Jordan20021997–200084043.432
Paraguay20031998–200041022.733
Paraguay20021999–200014142.534
Peru20011995–199738652.035
South Africa20031997–19991,52532.017
Thailand20042001–200299244.023
Turkey20032000–200192039.836
High-middle
Argentina20011996–19981,31242.037
Argentina20011997–199813335.338
Chile20011997–199927647.039
Malaysia20042001–20021,37457.023
Malaysia20031996–19991,36224.040
Poland2000199777335.641
Venezuela20011997–199994638.039
High
France20021997–200070650.942
Germany20032001–200221747.043
Italy2002200133041.444
South Korea20001998–199924340.045
South Korea20031998–200034859.046
Spain20041998–20023,76031.047
Footnotes
Suggested citation for this article: Parashar UD, Gibson CJ, Bresee JS, Glass RI. Rotavirus and severe childhood diarrhea. Emerg Infect Dis [serial on the Internet]. 2006 Feb [date cited]. http://dx.doi.org/10.3201/eid1202.050006
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