The authors acknowledge Program Office: National Heart, Lung, and Blood Institute, Bethesda, MD (Elizabeth Nabel, Jacques Rossouw, Shari Ludlam, Joan McGowan, Leslie Ford, and Nancy Geller); Clinical Coordinating Center: Fred Hutchinson Cancer Research Center, Seattle, WA (Ross Prentice, Garnet Anderson, Andrea LaCroix, Charles L. Kooperberg, Ruth E. Patterson, and Anne McTiernan); Medical Research Labs, Highland Heights, Kentucky: Evan Stein. University of California at San Francisco, San Francisco, CA (Steven Cummings); Clinical Centers: Albert Einstein College of Medicine, Bronx, NY (Sylvia Wassertheil-Smoller); Baylor College of Medicine, Houston, TX (Aleksandar Rajkovic); Brigham and Women's Hospital, Harvard Medical School, Boston, MA (JoAnn E. Manson); Brown University, Providence, Rhode Island: Charles B. Eaton, Emory University, Atlanta, GA (Lawrence Phillips); Fred Hutchinson Cancer Research Center, Seattle, WA (Shirley Beresford); George Washington University Medical Center, WA, DC (Lisa Martin); Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA (Rowan Chlebowski); Kaiser Permanente Center for Health Research, Portland, OR (Yvonne Michael); Kaiser Permanente Division of Research, Oakland, CA (Bette Caan); Medical College of Wisconsin, Milwaukee, WI (Jane Morley Kotchen); MedStar Research Institute, Howard University, WA, DC (Barbara V. Howard); Northwestern University, Chicago/Evanston, IL (Linda Van Horn); Rush Medical Center, Chicago, IL (Henry Black); Stanford Prevention Research Center, Stanford, CA (Marcia L. Stefanick); State University of New York at Stony Brook, Stony Brook, NY (Dorothy Lane); The Ohio State University, Columbus, OH (Rebecca Jackson); University of Alabama at Birmingham, Birmingham, AL (Cora E. Lewis); University of Arizona, Tucson, Phoenix, AZ (Cynthia A. Thomson); University at Buffalo, Buffalo, NY (Jean Wactawski- Wende); University of California at Davis, Sacramento, CA (John Robbins); University of California at Irvine, CA (F. Allan Hubbell); University of California at Los Angeles, Los Angeles, CA (Lauren Nathan); University of California at San Diego, La Jolla/Chula Vista, CA (Robert D. Langer); University of Cincinnati, Cincinnati, OH (Margery Gass); University of Florida, Gainesville/Jacksonville, FL (Marian Limacher); University of Hawaii, Honolulu, HI (J. David Curb); University of Iowa, Iowa City/Davenport, IA (Robert Wallace); University of Massachusetts, Fallon Clinic, Worcester, MA (Judith Ockene); University of Medicine and Dentistry of New Jersey, Newark, NJ (Norman Lasser); University of Miami, Miami, FL (Mary Jo O'Sullivan); University of Minnesota, Minneapolis, MN (Karen Margolis); University of Nevada, Reno, NV (Robert Brunner); University of North Carolina, Chapel Hill, NC (Gerardo Heiss); University of Pittsburgh, Pittsburgh, PA (Lewis Kuller); University of Tennessee Health Science Center, Memphis, TN (Karen C. Johnson); University of Texas Health Science Center, San Antonio, TX (Robert Brzyski); University of Wisconsin, Madison, WI, (Gloria E. Sarto); Wake Forest University School of Medicine, Winston-Salem, NC (Mara Vitolins); Wayne State University School of Medicine, Hutzel Hospital, Detroit, MI (Michael Simon). The WHI Program is funded by the National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, US Department of Health and Human Services through Contracts N01WH22110, 24152, 32100-2, 32105-6, 32108-9, 32111-13, 32115, 32118-32119, 32122, 42107-26, 42129-32, and 44221. This work was also supported by PO1 CA53996, R01AG025441-03, and T32 AG027677. R. Seguin is supported by the T32 AG027677 fellowship sponsored by the National Institute of Aging. A. LaCroix was supported by 5R01AG025441-03 sponsored by the National Institute of Aging. M. LaMonte was supported by HHSN26820110001C sponsored by the National Heart Lung and Blood Institute. L. Tinker was supported by N01-WH-2-2110 sponsored by the National Heart Lung and Blood Institute. J. Liu was supported by N01-WH-2-2110 sponsored by the National Heart Lung and Blood Institute. J. Liu had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Y. Michael was supported by R03AG031973 sponsored by the National Institute of Aging. C. Bushnell was supported by NIH K02 NS058760 sponsored by the National Institute for Neurological Disorders and Stroke.