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Adv Virol. 2012; 2012: 508967.
Published online May 16, 2012. doi:  10.1155/2012/508967
PMCID: PMC3361994
Interplay between HIV-1 and Host Genetic Variation: A Snapshot into Its Impact on AIDS and Therapy Response
Raghavan Sampathkumar, 1 Elnaz Shadabi, 1 and Ma Luo 1, 2 *
1Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada R3E 0J9
2National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada R3E 3R2
*Ma Luo: ma.luo/at/phac-aspc.gc.ca
Academic Editor: Nicola Coppola
Received December 9, 2011; Revised February 26, 2012; Accepted March 11, 2012.
Abstract
As of February 2012, 50 circulating recombinant forms (CRFs) have been reported for HIV-1 while one CRF for HIV-2. Also according to HIV sequence compendium 2011, the HIV sequence database is replete with 414,398 sequences. The fact that there are CRFs, which are an amalgamation of sequences derived from six or more subtypes (CRF27_cpx (cpx refers to complex) is a mosaic with sequences from 6 different subtypes besides an unclassified fragment), serves as a testimony to the continual divergent evolution of the virus with its approximate 1% per year rate of evolution, and this phenomena per se poses tremendous challenge for vaccine development against HIV/AIDS, a devastating disease that has killed 1.8 million patients in 2010. Here, we explore the interaction between HIV-1 and host genetic variation in the context of HIV/AIDS and antiretroviral therapy response.
Articles from Advances in Virology are provided here courtesy of
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