In almost all traditional system of medicine, the quality control aspect has been covered by careful observation of skillful physicians. However, in modern concept, it requires necessary changes in their approach by way of quality control in terms of development of modern methodologies. Thus, today quality assurance is a thrust area for the evaluation of traditionally used medicinal plants and herbal formulations. Manufacturers who are doing some testing of their formulation have fixed their own parameter; most of them are only preliminary in nature. Combined and well-coordinated efforts from scientific workers of different disciplines are required for this purpose. Weight variation of tablet causes variation of active medicament which changes the bioavailability. This may be due to causes such as variation in granule size, poor flow, bridging, rat holing, punch variation and poor mixing.
MMV tablets were found to have (mean ± SD) 345.88 mg average weight. 90% tablets were within acceptable range of weight variation as for natural – herbal products, ±10% range of weight variation is acceptable. Both hardness and disintegration time interfere with the bioavailability of drug. MMV was found to have 1.25 kg/cm2
hardness and 17 min disintegration time which was noticed with in accepted limits.[9
] Moisture content should be minimum to prevent degradation of product. Excess of water in drug encourage microbial growth, presence of fungi or insects and deterioration following hydrolysis. MMV contained 9.3% w/w moisture showing that the tablet should be protected from humid atmosphere by keeping silica bag in it as climatic changes affect the tablet. The result shows that if it would not be protected in humid atmosphere, then water activity would be increased and it will cause degradation of the tablet. Ash values are the criteria to judge the identity and purity of crude drug, where total, water soluble and acid insoluble ashes are considered. Mehamudgara vati
contained 45.65% w/w of total ash and 0.9% w/w acid insoluble ash. The result revealed that MMV is free from unwanted organic and inorganic compounds and production site was good enough keeping sample free from dust and other soil matters etc. The 24.06%w/w of water soluble and 14.10% w/w of methanol soluble extractive were present in MMV indicating that the drug is having good solubility in water. Though, Mehamudgara vati
is prescribed for prameha
(type-II Diabetes) in classics, it is indicated in pandu
(iron deficiency anemia) too which is proven in present study by revealing the fact that it contains 28.67% of Fe2
 as Lauha bhasma
is the main ingredient of MMV. In TLC of MMV, five spots at 254 nm and six spots at 366 nm were noticed [ and ] indicating its possible compounds of the matrix which may possess its therapeutic effect.
Result of thin layer chromatography
TLC Profile of Mehamudgara vati(MMV)