Baseline characteristics of the 20 included patients are presented in .
In regions of PPE the TMax delay of 5.7 seconds (4.7-7.2) was higher compared to the corresponding contralateral mirror ROI, 3.5 seconds (2.9-4.5), p<0.001, and ipsilateral hemisphere ROI: 3.7 seconds (3.2-4.5), p<0.001 (). PPE TMax delay was higher in patients scanned within 24 hours after symptom onset (n=10) p=0.017. Among the 7 patients with a mean TMax delay above 6 seconds, ICH volumes on FLAIR were larger 49 cc (19-60) compared with the remaining patients 14cc (8-18), p=0.046, however, edema volumes were not different.
Mean Tmax value (a); Mean Absolute ADC (b) and rADC (c) in the PPE, its corresponding opposite ROI, in the ipsilateral hemisphere and its corresponding ROI.
The mean ADC measured in the PPE, 1026 (972-1099) ×10−6 mm2/second, was higher than the mirror ROI: 895 (801-1033) ×10−6 mm2/second, p=0.004, and the ipsilateral hemisphere ROI: 878 (802-962) ×10−6 mm2/second, p<0.001(). In the PPE, rADC, 1.16 (1.04-1.28), was higher compared to the rADC measured in the contralateral hemisphere ROI: 0.93 (0.88-0.99), p=0.003. There was no relation between the absolute or rADC in the PPE and ICH volume, edema volume, MRI delay or corresponding TMax delay. Fourteen patients (70%) exhibited restricted diffusion lesions within the PPE with a mean ADC value of 814 (744-957) ×10−6 mm2/second. These patients had larger ICH volumes measured on FLAIR, 28cc. (15.4-74.6) vs. 11.3cc (8.7-13.9), p=0.03, but there was no relation with the corresponding TMax delay, edema volume or time from symptom onset to MRI.
MRI profile according to ICH cause
Patients with both primary and secondary causes of ICH exhibited a delayed TMax and increased ADC in the PPE.
Among the 14 patients with restricted diffusion lesions in the PPE, ICH causes were hypertension (10), CAA (1), vascular malformation (2) and hemorrhagic transformation of brain infarction (1).