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Function similarity (all ontologies combined) of corresponding 11 orthologs among human, mouse, and an outgroup.
The outgroups are (A) D. melanogaster, (B) S. cervisiae, and (C) E. coli. Strikingly, function is maintained among 11 orthologs over all evolutionary ranges considered here. Histograms represent sample density partitioned for each homology type, and error bars represent the 95% confidence interval around the mean.