This publication was made possible by Grant Number U10HL083721 from the National Heart, Lung, and Blood Institute, National Institutes of Health. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Institutes of Health.
The manuscript was drafted by a core writing group that consisted of Dr. Styles, Dr. Miller, and Dr. Wager. Dr. Wager conducted the statistical analysis. All other authors contributed substantially to the design, acquisition and interpretation of data, critical revisions of the manuscript, and approval of the final versions.
In addition to the authors of this manuscript, the following individuals were instrumental in the planning, conduct and/or care of patients enrolled in this study at each of the participating institutions as follows:
Emory University, AFLAC Cancer Center and Blood Disorders Service, Atlanta, GA: Carlton D. Dampier, MD
Aflac Cancer Center and Blood Disorders Service, Emory University School of Medicine and Children’s Healthcare of Atlanta, Atlanta, GA: Peter A. Lane, MD, Tamara N. New, MD, Terrell Faircloth, CCRC
Boston Medical Center, Boston, MA:, Asif I. Qureshi, MD
Children’s Hospital Boston, Boston, MA: Matthew M Heeney, M.D, Debra L. Weiner, M.D., Ph.D., Meredith Anderson; For GCRC-supported studies: “This project was funded in part by grant MO1-RR02172 from the National Center for Research Resources, National Institutes of Health, to the Children’s Hospital Boston General Clinical Research Center.” Abbreviations may include NCRR, NIH, and GCRC.
Children’s Hospital of Philadelphia, Philadelphia, PA: Kwaku Ohene-Frempong, MD, Clinical and Translational Research Center, Children’s Hospital of Philadelphia, CTRC grant number UL1-RR-024134
St. Christopher’s Hospital for Children, Philadelphia, PA: Norma B. Lerner, MD, MPH, Michele Cahill, RN, MaryLou MacDermott, CRNP, Maureen Meier, RN, CCRC
Division of Pediatric Hematology/Oncology, AI DuPont Hospital for Children, Wilmington, DE: Lynn Marrs, BS, RN, CCRC
Division of Pediatric Hematology/Oncology, University of Louisville, Louisville, KY: Salvatore Bertolone, MD, Ashok B. Raj, MD
Center for Sickle Cell Disease and Department of Medicine, Howard University, Washington, DC: Victor R. Gordeuk, MD, Georgetown-Howard Universities Center for Clinical and Translational Science and supported by the National Institutes of Health National Center for Research Resources, Grant U54 RR026076
Children’s Hospital & Research Center, Oakland, CA: Mark Walters, MD;
University of Illinois at Chicago, Chicago, IL: Richard J. Labotka, MD, Robert Molokie, MD, Sandra Gooden, RN, Daisy Pacelli, MPH, RN, Lani Krauz, RN
Virginia Commonwealth University, Richmond, VA: Wally R. Smith, MD, Kamar Godder, MD, MPH, Susan D. Roseff, MD
Johns Hopkins University School of Medicine, Baltimore, MD: James F. Casella, MD, Jeffrey Keefer, MD, PhD, Sophie Lanzkron MD, MHS, Cedron Williams, Phillip Seaman; Johns Hopkins University: Johns Hopkins Institute for Clinical and Translational Research; grant # U10 HL083721.
University of North Carolina at Chapel Hill, Chapel Hill, NC: Susan K. Jones, RN, Dell Strayhorn, FNP, MPH, Teresa Etscovitz; UNC Clinical and Translational Science Award,” grant # UL1RR025747
University of Mississippi Medical Center, Jackson, MS: Mary Gail Smith, MD, Carolyn Bigelow, MD, Suvankar Majumdar, MD, Glenda Thomas, RN, Arleen Anderson, RN
Medical College of Georgia, Atlanta, GA: Abdullah Kutlar, MD, Leigh Wells, RN, MSN, Latanya Bowman, Pritam Bora
Wayne State University, Detroit, MI: Paul Swerdlow, MD
Duke University Medical Center, Durham, NC: Marilyn J. Telen, MD, Laura M. De Castro, MD, Shital Kamble, PhD, Shelby Reed, PhD, Courtney D. Thornburg, MD, Hai Huang, Jude Jonassaint, RN
New York Methodist Hospital, Brooklyn, NY: Emmely M. Colon, Herold Duroseau, MD, Deepak Kilari, MD, Charlene Webb, LPN
Interfaith Medical Center, Brooklyn, NY: Edouard Guillaume, MD, Rafat Ahmed, MD, Miren Blackwood, Huguette Souffrant, Hossam Awad
Cincinnati Children’s Hospital Medical Center, Cincinnati, OH: Karen Kalinyak, MD, Clinton H. Joiner, MD, PhD
Ohio State University, Adult Sickle Cell Program Columbus, OH: Eric H. Kraut, MD, Leslie Witkoff, RN
Nationwide Children’s Hospital, Columbus OH: Melissa M. Rhodes, MD, Kami Perdue, CRA
New England Research Institutes, Watertown, MA: Sonja M. McKinlay, PhD, Beatrice Files, MD, Hae-Young Kim, DrPH, David Brazier, PMP, Margaret C. Bell, MS, MPH, Dianne Gallagher, MPH
National Heart, Lung, and Blood Institute, Bethesda, MD: Harvey Luksenburg, MD, Henry Chang, MD, Liana Harvath, PhD, Myron Waclawiw, PhD, Erin Smith, Ellen M. Werner, PhD
Data and Safety Monitoring Board Members: (Chair) Ted Wun, MD, FACP, Amy Becker, MD, Lennette Benjamin, MD, Susan Claster, MD, Michael Farrell, MD, Allison A. King, MD, MPH, Jeannette Y. Lee, PhD, Robert P. McMahon, PhD, Julie A. Panepinto, MD, MSPH
Finally, the SCDCRN thanks the individuals who enrolled in the trial and their families.