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Behav Res Ther. Author manuscript; available in PMC 2013 June 1.
Published in final edited form as:
PMCID: PMC3348973
NIHMSID: NIHMS370064

Treating PTSD in Suicidal and Self-injuring Women with Borderline Personality Disorder: Development and Preliminary Evaluation of a Dialectical Behavior Therapy Prolonged Exposure Protocol

Abstract

This study focused on the development and pilot testing of a protocol based on Prolonged Exposure (PE) that can be added to Dialectical Behavior Therapy (DBT) to treat PTSD in suicidal and self-injuring individuals with borderline personality disorder (BPD). Women with BPD, PTSD, and recent and/or imminent serious intentional self-injury (n=13) received one year of DBT with the DBT PE Protocol, plus three months of follow up assessment. The treatment was associated with significant reductions in PTSD, with the majority of patients no longer meeting criteria for PTSD at post-treatment (71.4% of DBT PE Protocol completers, 60.0% of the intent-to-treat sample). A minority of patients (27.3%) engaged in intentional self-injury during the study. Improvements were also found for suicidal ideation, dissociation, trauma-related guilt cognitions, shame, anxiety, depression, and social adjustment. There was no evidence that the DBT PE Protocol led to exacerbations of intentional self-injury urges or behaviors, PTSD, treatment dropout, or crisis service use. Overall, the results indicate that this integrated BPD and PTSD treatment is feasible to implement within one year of treatment, highly acceptable to patients and therapists, safe to administer, and shows promise as an effective intervention for PTSD in this complex and high-risk patient population.

Keywords: Borderline personality disorder, posttraumatic stress disorder, suicide, self-injury

The high comorbidity between borderline personality disorder (BPD) and posttraumatic stress disorder (PTSD) is well-documented, with approximately 30–50% of individuals with BPD also meeting criteria for PTSD (Harned, Rizvi, & Linehan, 2010b; Pagura et al., 2010). Individuals with BPD and PTSD are more impaired in terms of global psychological distress, Axis I comorbidity, emotion dysregulation, and suicidal and non-suicidal self-injury (NSSI) than those with BPD alone (Harned et al., 2010; Pagura et al., 2010). Overall, the presence of PTSD predicts a lower likelihood of remitting from BPD across ten years of naturalistic follow-up (Zanarini, Frankenburg, Hennen, Reich, & Silk, 2006).

Despite the frequent co-occurrence of BPD and PTSD, few approaches exist for treating PTSD among BPD patients, particularly those with recent intentional self-injury (i.e., suicide attempts and/or NSSI). PTSD treatment guidelines uniformly recommend addressing imminent suicidality before treating PTSD (e.g, Foa, Keane, Friedman, & Cohen, 2009) and acutely suicidal patients are routinely excluded from PTSD treatment studies (Bradley, Greene, Russ, Dutra, & Westen, 2005). Of the PTSD treatment studies that have reported including BPD patients, all excluded recently and/or imminently suicidal patients and the majority excluded patients with a variety of other problems that frequently co-occur with severe BPD (e.g., NSSI, substance dependence; Clarke, Rizvi, & Resick, 2008; Feeny, Zoellner, & Foa, 2002; Cloitre et al., 2010; Steil, Dyer, Priebe, Kleindienst, & Bohus, 2011; Mueser et al., 2008; McDonagh et al., 2005). Thus, no treatments exist that target PTSD among suicidal and self-injuring patients in general, or those with BPD in particular.

In contrast, BPD treatments include suicidal and self-injuring patients but often do not target their PTSD. Dialectical Behavior Therapy (DBT; Linehan, 1993), the most empirically supported treatment available for BPD, recommends the use of exposure to treat PTSD, but does not include a protocol specifying when or how to do this. Thus, although DBT is effective in reducing intentional self-injury among BPD patients with PTSD (Harned, Jackson, Comtois, & Linehan, 2010a), studies to date have not targeted PTSD specifically. As a result, the rate of PTSD remission in DBT is relatively low (35%; Harned et al., 2008). Studies of other BPD treatments have not included PTSD as an outcome (Bateman & Fonagy, 1999; Blum et al., 2008; Clarkin, Levy, Lenzenweger, & Kernberg, 2007; Giesen-Bloo et al., 2006).

The present study focused on developing a protocol based on Prolonged Exposure (PE; Foa, Hembree, & Rothbaum, 2007) that can be added to DBT to treat PTSD among suicidal and self-injuring BPD patients. PE was selected because exposure therapies are the most empirically supported treatments available for PTSD (Institute of Medicine, 2007), and PE is the most researched exposure treatment (Powers, Halpern, Ferenschak, Gillihan, & Foa, 2010). The combined DBT and DBT PE Protocol treatment differs from existing approaches by: (1) providing integrated, concurrent treatment for BPD and PTSD, (2) including suicidal and self-injuring patients, (3) implementing standard DBT (instead of modified DBT) in combination with exposure therapy for PTSD (PE), and (4) incorporating strategies and procedures designed to address the specific needs and complexities of this patient population. Initial case studies of this treatment have been published previously (Harned & Linehan, 2008) and the present study focused on the continued development and pilot testing of the treatment using an open trial design. Specifically, the current study evaluated whether DBT with the DBT PE Protocol was: (1) associated with improvements in PTSD and intentional self-injury as well as secondary outcomes, (2) feasible to implement, (3) acceptable to patients and therapists, and (4) safe to administer.

Methods

Participants

Participants were 13 women (aged 18–60) with BPD, PTSD, and recent and/or imminent suicidal behavior or serious NSSI, defined as: (a) recent (past 3 months) suicide attempt or serious NSSI, and/or (b) imminent threat of suicidal behavior (i.e., current moderate to severe suicidal ideation with a suicide plan and intent to commit suicide within the next 4 weeks). Participants were excluded if they met criteria for a psychotic disorder, mental retardation, or bipolar disorder, or were mandated to treatment. All data were collected in accord with IRB approved procedures.

Recruitment and Assessments

Participants were recruited via outreach to area treatment providers and advertisements. Enrollment and follow-up ran from August 2009 through April 2011. After an initial phone screen, participants completed an in-person assessment to evaluate study inclusion/exclusion criteria. Outcome assessments occurred at 6 months (mid-treatment), 12 months (post-treatment), and 15 months (3-month follow-up). All assessments were conducted by independent clinical assessors who had been trained to reliability by the instrument developer or an approved trainer. A total of 49 individuals completed the initial phone screen, 28 passed the initial phone screen, and 22 completed the in-person screening assessment. Fourteen participants were accepted into the study and, of these, 13 attended at least one therapy session (i.e., the intent-to-treat (ITT) sample).

Therapists

Therapists (n=6) were primarily female (83.3%), doctoral (50%) or masters-level (50%) clinicians, and had an average of 6.5 years of post-degree clinical experience (SD = 4.2). Individual therapists treated an average of 4.3 patients (SD = 0.6). All but one therapist had attended a DBT Intensive Training and all individual therapists attended a PE Intensive Training and received PE expert consultation on their first two patients.

Treatment

All patients received one year of standard DBT, including (1) individual therapy (1 hr/wk), (2) group skills training (2.5 hr/wk), (3) phone consultation (as needed), and (4) therapist consultation team meeting (1 hr/wk). The DBT PE Protocol was implemented during the one year of DBT once patients achieved sufficient control over higher-priority targets. Specifically, the following criteria were used to determine readiness to begin the DBT PE Protocol: (1) not at imminent risk of suicide, (2) no recent (past 2 months) suicide attempts or NSSI1, (3) ability to control life-threatening behaviors when in the presence of cues for those behaviors, (4) no serious therapy-interfering behaviors, (5) PTSD is the highest priority target for the patient, and (6) ability and willingness to experience intense emotions without escaping. The DBT PE Protocol was implemented concurrently with standard DBT such that patients received either one combined individual therapy session per week (90 minutes of the DBT PE Protocol and 30 minutes of DBT) or two individual therapy sessions per week (one DBT PE Protocol session (90 minutes) and one DBT session (1 hour)) as well as group DBT skills training and as needed phone consultation. The duration of the DBT PE Protocol was based on continuous assessment of the patient’s PTSD symptoms and treatment goals.

The DBT PE Protocol is based on PE (Foa et al., 2007) and utilizes in vivo and imaginal exposure as the primary treatment components. DBT strategies and procedures were incorporated into PE to: (1) increase monitoring of potential negative reactions to exposure (e.g., pre-post exposure ratings of urges to commit suicide), (2) target problems that may occur during or as a result of exposure (e.g., via DBT skills and protocols), and (3) utilize DBT therapist strategies (e.g., dialectics, irreverence, validation) that address the particular needs of severe BPD patients. The protocol also includes procedures for addressing higher-priority behaviors that may occur during the treatment, including a requirement that the protocol be stopped (ideally temporarily) if any form of intentional self-injury recurs. See Harned (in press) for a detailed description of the DBT PE Protocol.

Measures

Sample characteristics

The International Personality Disorder Examination (Loranger, 1995) was used to diagnose Axis II disorders and the Structured Clinical Interview for DSM-IV, Axis I (First, Spitzer, Gibbon, & Williams, 1995) was used to diagnose all Axis I disorders except PTSD. The PTSD Symptom Scale – Interview (PSS-I; Foa, Riggs, Dancu, & Rothbaum, 1993) was used to diagnose PTSD in relation to a specific index trauma. The Traumatic Life Events Questionnaire (Kubany et al., 2000) and the Childhood Experiences Questionnaire (Linehan, unpublished) assessed lifetime history of 25 types of traumatic events.

Treatment feasibility

Feasibility of the treatment was assessed via rates of treatment retention and completion of the DBT PE Protocol. Completing DBT was defined as attending one year of treatment without missing four consecutive weeks of either individual therapy or group skills training. Completing the DBT PE Protocol was defined as completing at least 6 sessions of the protocol.

Treatment acceptability

Participants’ preferred treatment (DBT alone, PE alone, or a combined DBT and PE treatment) was assessed at intake using an adapted version of Zoellner and colleagues’ (2003) treatment choice measure. An adapted version of the Expectancies Questionnaire (Shaw et al., 1999) assessed patient and therapist treatment expectancies (range = 1–7). The Client Satisfaction Questionnaire (Larsen, Attkisson, Hargreaves, & Nguyen, 1979) measured patients’ satisfaction with the treatment at post-treatment (range = 1–4).

Treatment safety

Urges to commit suicide and self-injure (range = 0–5) were assessed immediately before and after each individual therapy session, as well as before and after each imaginal and in vivo exposure task (both in-session and homework tasks). The occurrence of suicide attempts, NSSI, and crisis service use (i.e., inpatient hospitalizations, emergency room visits for psychological reasons) during the DBT PE Protocol was measured via the Suicide Attempt Self-Injury Interview (SASII; Linehan, Comtois, Brown, Heard, & Wagner, 2006a) and the Treatment History Interview (Linehan & Heard, unpublished).

Primary clinical outcomes

PTSD

The PSS-I (Foa et al., 1993) assessed the presence and severity of PTSD during the past two weeks at each outcome assessment. Reliable change in PTSD symptoms was defined as a change larger than the standard error of the difference between two measurements, given by the formula SED = √[2(SEM2)], where SEM = SD*√(1-r). This value was calculated as a change greater ± 7.53 points using data from a large sample (N = 196) of female assault survivors (Foa, unpublished data).

Intentional self-injury

The SASII (Linehan et al., 2006a) assessed the frequency of suicide attempts and NSSI and the Suicidal Behaviors Questionnaire (Linehan, unpublished work) assessed the frequency of self-reported suicidal ideation at each outcome assessment.

Secondary clinical outcomes

Three self-report measures assessed pathological dissociation (Dissociative Experiences Scale – Taxon; Waller & Ross, 1997), trauma-related guilt cognitions (Trauma Related Guilt Inventory; Kubany et al., 1996), and shame (Experience of Shame Scale; Andrews, Qian, & Valentine, 2002). Interviewer-rated depression and general anxiety were assessed via the Hamilton Rating Scale for Depression (Hamilton, 1960) and Hamilton Rating Scale for Anxiety (Hamilton, 1959). Social functioning was measured via an interviewer-rated Global Social Adjustment (GSA) score for the worst week in the past month. All outcomes were measured at baseline and each outcome assessment with the exception of GSA (pre-post only).

Statistical Methods

All outcome analyses were conducted for both the ITT and DBT PE Protocol completer samples. Mixed-effects models (hierarchichal linear models and mixed model analyses of variance) were used to analyze within-group change as a function of time for measures that were assessed at multiple outcome points. Paired-sample t-tests were used for outcomes that were only assessed at pre- and post-treatment. Effect sizes were calculated using Cohen’s d statistic following a formula that corrects for the correlation between means in a single-group repeated measures design: d = MpostMpre /SDchange scores, where SDchange scores = √SD2 pre + SD2 post − [(2) (r)(SDpre) (SDpost)]. The sample size of 13 had power of 75.4% to detect a large effect (i.e., d = 0.8) with α=.05 and assuming the within-subject correlation was ρ=0.5.

Results

Sample Characteristics

Participants were an average age of 39.4 years (SD = 11.4), primarily White (69.2%), non-married (61.5%), not college graduates (69.2%), and low income (< $20,000 per year; 90.9%). Participants reported an average of 14.0 types of lifetime trauma (SD = 5.5) beginning before age 6 (M age of onset= 5.2, SD = 3.0). Index traumas included: childhood sexual abuse (61.5%), adult rape (15.4%), childhood physical abuse (7.7%), witnessing family violence (7.7%), and suicide of a parent (7.7%). In the past year, 23.1% had attempted suicide (M attempts = 0.3, SD = 0.6) and 92.3% had engaged in NSSI (M acts = 38.3, SD = 69.3). Participants met criteria for an average of 4.6 current Axis I disorders (SD = 1.4) and 2.2 Axis II disorders (SD = 1.1).

Treatment Feasibility

Treatment retention

Ten patients (76.9%) completed one year of DBT and 3 (23.1%) dropped out of treatment prematurely. All three patients who dropped out of treatment did so before beginning the DBT PE Protocol and reasons for premature dropout were: moved out of state (n=1), concerns about the pharmacotherapy protocol (n=1), and unknown (n=1).

DBT PE Protocol implementation

Of the 10 patients who completed one year of DBT, 100% started the DBT PE Protocol and this occurred at week 18.5 of DBT on average (range = 7–30, SD = 7.7). The majority of these patients (n=7, 70%) completed the DBT PE Protocol in an average of 13.0 sessions (range = 6–19, SD = 4.5) during which an average of 2.4 trauma memories were targeted (range = 1–5, SD = 1.6). Three patients (30%) started but did not complete the DBT PE Protocol (M sessions = 2.7, SD = 0.6, range = 2–3). Reasons for non-completion were: unwilling to experience intense emotions elicited by exposure (n=1), failure to sufficiently control NSSI (n=1), and increased auditory hallucinations (n=1).

Treatment Acceptability

At intake, the majority of patients indicated a preference for a combined DBT and PE treatment (n=10, 76.9%) and the remainder preferred to receive DBT only (n=3, 23.1%). Patients reported very positive treatment expectancies at all time points (Ms = 5.5 – 6.4, SDs = 0.4 – 1.0) and were highly satisfied with the treatment they received at post-treatment (M = 3.6, SD = 0.3). Therapist treatment expectancies were also very positive (Ms = 5.5 – 6.1, SDs = 1.3 – 1.4).

Treatment Safety

As shown in Table 1, the average intensity of pre- and post-session urges to commit suicide and self-injure did not differ between DBT and DBT PE Protocol sessions. There was a significant difference in the pattern of change in urges to commit suicide by session type; namely, suicide urges were more likely to decrease after a DBT PE Protocol session than a DBT session (46.9% vs. 25.8%; χ2 (1) = 8.4, p < .01). The pattern of change in urges to self-injure did not significantly differ between the two types of sessions. Overall, the likelihood of suicide and self-injury urges increasing after individual therapy sessions was low (<20% of sessions) and comparable for DBT and DBT PE Protocol sessions. Similarly, urges to commit suicide and self-injure rarely increased as an immediate result of completing an exposure task (<7% of tasks).

Table 1
Urges to Commit Suicide, Self-Injure, and Use Substances Before and After Individual Therapy Sessions and Exposure Tasks

Of the 10 patients who started the DBT PE Protocol, 2 (20%) engaged in intentional self-injury during this portion of the treatment (suicide attempt and NSSI (n=1), NSSI only (n=1)2). The patient who attempted suicide also had two episodes of crisis service use during the DBT PE Protocol, which was not an increase from baseline. No other patients utilized crisis services at any time during the treatment year.

Clinical Outcomes

Descriptive data and within-group effect sizes are presented in Table 2 and results of the mixed effects models are shown in Table 3.

Table 2
Means, Standard Deviations, and Within-Group Effect Sizes for each Outcome Measure by Timepoint and Treatment Completer Status
Table 3
Results of Mixed Effects Models

Primary outcomes

PTSD

There was a large and significant reduction in PTSD severity in the ITT sample and among DBT PE Protocol completers. At post-treatment, the majority of patients had experienced a reliable improvement in PTSD (85.7% of the DBT PE Protocol completers, 70.0% of the ITT sample) and the remainder had no reliable change (14.3% of DBT PE Protocol completers, 30.0% of the ITT sample). Rates of PTSD remission were also high at post-treatment (71.4% of the DBT PE Protocol completers, 60.0% of the ITT sample). Improvements in PTSD severity were maintained in the three months after treatment ended. At 3-month follow-up, PTSD severity remained significantly reduced compared to pre-treatment and rates of reliable improvement (85.7% of DBT PE Protocol completers, 81.8% of the ITT sample) and remission (57.1% of DBT PE Protocol completers, 45.5% of the ITT sample) remained high.

Intentional self-injury

Three patients (27.3%) engaged in intentional self-injury during the study (suicide attempt: n=1, 9.1%, NSSI: n=3, 27.3%). Given the low frequency of intentional self-injury, mixed effects models could not be estimated. Effect sizes for changes in the frequency of intentional self-injury acts were moderate in the ITT sample and large among DBT PE Protocol completers. There was also a significant and large reduction in suicidal ideation in both samples.

Secondary outcomes

Moderate to large pre-post effect sizes were found for all secondary outcomes (i.e., dissociation, trauma-related guilt cognitions, shame, anxiety, depression, global social adjustment) among DBT PE Protocol completers, and for all secondary outcomes except depression in the ITT sample. Mixed effects models found significant reductions across time for the majority of secondary outcomes in both samples and all treatment gains were maintained in the 3 months after treatment ended. Finally, global social adjustment improved significantly from pre- to post-treatment in both samples (p’s < .01).

Discussion

The combined DBT and DBT PE Protocol treatment was acceptable and feasible to implement for the majority of patients. Both patients and therapists reported positive treatment expectancies and patients were highly satisfied with the treatment they received. The rate of treatment dropout was low (23.1%) and comparable to the rate found in a meta-analysis of DBT studies (27.3%; Kliem, Kroger, & Kosfelder, 2010). Of the patients who completed DBT, 100% achieved the stability necessary to begin the DBT PE Protocol and 70% completed it within the year of treatment. The average duration of the DBT PE Protocol (13 sessions) is consistent with PE and the rate of non-completion (30%) is similar to the dropout rate found in PE studies (34%; Foa et al., 2005). These findings suggest that, when administered concurrently with DBT, severe BPD patients do not require significantly lengthier PTSD treatment, nor are they more likely to fail to complete PE than other types of PTSD patients.

The DBT PE Protocol was also safe to implement in this high-risk population. Urges to commit suicide and self-injure rarely increased immediately after completing an exposure task (<7% of tasks) and the intensity of pre- and post-session urges to commit suicide and self-injure did not differ between DBT and DBT PE Protocol sessions. The rates of intentional self-injury relapse and crisis service use during the DBT PE Protocol were both low (10%). More generally, few patients attempted suicide (9.1%) or engaged in NSSI (27.3%) during the study and these rates are lower than those typically found in DBT studies (e.g., Linehan et al., 2006b; McMain et al., 2009). Clinical observations suggest that the low incidence of intentional self-injury was primarily due to making the delivery of the DBT PE Protocol explicitly contingent on achieving control over these behaviors. Specifically, the promise of receiving an effective treatment for a problem viewed by the patient as high-priority appeared to function as a powerful reinforcer to quickly gain control over intentional self-injury. Thus, rather than exacerbating intentional self-injury urges and behaviors, the addition of the DBT PE Protocol to DBT may actually decrease the frequency of these behaviors, particularly among patients who are motivated to receive PTSD treatment.

The treatment was also associated with significant and stable reductions in PTSD. At post-treatment and 3-month follow-up, effect sizes were large (d’s = 1.4–2.3), most patients (70–86%) experienced a reliable improvement in PTSD, and no patients exhibited a reliable worsening. The majority of patients also achieved remission from PTSD at post-treatment (DBT PE Protocol completers = 71.4%, ITT = 60.0%). These results are comparable to those found in a meta-analysis of exposure treatments for PTSD (d = 1.6, PTSD remission= 53–68%; Bradley et al., 2005), suggesting that the DBT PE Protocol is as effective as other exposure-based PTSD treatments.

The treatment was also associated with significant improvements in a variety of secondary outcomes, including dissociation, trauma-related guilt, shame, anxiety, depression, and global social adjustment. Thus, the combined DBT and DBT PE Protocol treatment appears to be well-equipped to address a wide range of problems that commonly co-occur with BPD and PTSD.

The primary limitations of the present study are the open trial design and the small sample size. Future randomized controlled trials using larger samples are needed to replicate these findings,

In summary, the present study provides preliminary data supporting the feasibility, acceptability, safety, and potential effectiveness of combining standard DBT with the DBT PE Protocol. This is the first treatment developed specifically for suicidal and self-injuring PTSD patients in general, and those with co-occurring BPD in particular. These patients are often viewed by clinicians as inappropriate for PTSD treatment and many have spent decades receiving mental health services that have not addressed their PTSD. This is concerning not only because of the suffering associated with chronic PTSD, but also because PTSD often maintains or exacerbates suicidality, self-injury, and other BPD-related problems. The present study provides hope for both patients and clinicians that PTSD can be effectively and safely treated in this complex patient population.

Highlights

  • Developed a DBT PE Protocol to treat PTSD in suicidal/self-injuring BPD patients.
  • DBT with the DBT PE Protocol was examined in an open trial.
  • The treatment was feasible to administer and acceptable to patients and therapists.
  • Improvements were found in intentional self-injury, PTSD, and secondary outcomes.
  • There was no evidence of any adverse reactions to the treatment.

Acknowledgments

This work was supported by grant R34MH082143 from the National Institute of Mental Health to the first author. We would like to thank the patients, therapists, assessors, and staff at the Behavioral Research and Therapy Clinics for their contributions to this research, as well as the staff at the Center for the Treatment and Study of Anxiety for providing training and consultation. We are also grateful for the statistical consultation provided by Dr. Robert Gallop. Drs. Harned, Korslund, and Linehan are trainers and consultants for Behavioral Tech, LLC.

Footnotes

Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Portions of this data were presented at the 2010 convention of the Association of Behavioral and Cognitive Therapies.

1For the purpose of treatment development, one patient was allowed to start the DBT PE Protocol who was still actively engaging in low-risk NSSI.

2The patient who engaged in NSSI only was the patient who was allowed to start the DBT PE Protocol while still engaging in low-risk NSSI. Thus, the NSSI that occurred during the DBT PE Protocol does not constitute a relapse as the behavior had never stopped.

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