1. Hotez PJ, Molyneux DH, Fenwick A, Kumaresan J, Sachs SE, et al. Control of neglected tropical diseases. N Engl J Med. 2007;357:1018–1027. [PubMed] 2. Hotez PJ, Brindley PJ, Bethony JM, King CH, Pearce EJ, et al. Helminth infections: the great neglected tropical diseases. J Clin Invest. 2008;118:1311–1321. [PMC free article] [PubMed] 3. de Silva NR, Brooker S, Hotez PJ, Montresor A, Engels D, et al. Soil-transmitted helminth infections: updating the global picture. Trends Parasitol. 2003;19:547–551. [PubMed] 4. Vandemark LM, Jia TW, Zhou XN. Social science implications for control of helminth infections in Southeast Asia. Adv Parasitol. 2010;73:137–170. [PubMed] 5. Alemu A, Atnafu A, Addis Z, Shiferaw Y, Teklu T, et al. Soil transmitted helminths and schistosoma mansoni infections among school children in Zarima town, northwest Ethiopia. BMC Infect Dis. 2011;11:189. [PMC free article] [PubMed] 6. Ziegelbauer K, Speich B, Mausezahl D, Bos R, Keiser J, et al. Effect of sanitation on soil-transmitted helminth infection: systematic review and meta-analysis. PLoS Med. 2012;9:e1001162. [PMC free article] [PubMed] 7. Bethony J, Brooker S, Albonico M, Geiger SM, Loukas A, et al. Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm. Lancet. 2006;367:1521–1532. [PubMed] 8. Holland CV. Predisposition to ascariasis: patterns, mechanisms and implications. Parasitology. 2009;136:1537–1547. [PubMed]
9. WHO. Deworming for health and development. Report of the third global meeting of the Partners for Parasite Control. Geneva: World Health Organization; 2005.
10. King CH. Parasites and poverty: the case of schistosomiasis. Acta Trop. 2010;113:95–104. [PMC free article] [PubMed]
11. WHO. Preventive chemotherapy in human helminthiasis: coordinated use of anthelminthic drugs in control interventions: a manual for health professionals and programme managers. Geneva: World Health Organization; 2006.
12. WHO. First WHO report on neglected tropical diseases 2010: working to overcome the global impact of neglected tropical diseases. Geneva: World Health Organization; 2010.
13. Otto GF. Ascaris lumbricoides: treatment, loss of worms and reinfestation. JAMA. 1930;95:194–196.
14. Singer BH, de Castro MC. Bridges to sustainable tropical health. Proc Natl Acad Sci U S A. 2007;104:16038–16043. [PubMed] 15. Anderson RM, Medley GF. Community control of helminth infections of man by mass and selective chemotherapy. Parasitology. 1985;90:629–660. [PubMed] 16. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6:e1000097. [PMC free article] [PubMed] 17. The PLoS Medicine Editors. Best practice in systematic reviews: the importance of protocols and registration. PLoS Med. 2011;8:e1001009. [PMC free article] [PubMed] 18. Keiser J, Utzinger J. Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis. JAMA. 2008;299:1937–1948. [PubMed] 19. Olsen A, Nawiri J, Friis H. The impact of iron supplementation on reinfection with intestinal helminths and Schistosoma mansoni in western Kenya. Trans R Soc Trop Med Hyg. 2000;94:493–499. [PubMed] 20. Skov T, Deddens J, Petersen MR, Endahl L. Prevalence proportion ratios: estimation and hypothesis testing. Int J Epidemiol. 1998;27:91–95. [PubMed] 21. Hesham Al-Mekhlafi M, Surin J, Atiya AS, Ariffin WA, Mohammed Mahdy AK, et al. Pattern and predictors of soil-transmitted helminth reinfection among aboriginal schoolchildren in rural Peninsular Malaysia. Acta Trop. 2008;107:200–204. [PubMed] 22. Olsen A, Thiong'o FW, Ouma JH, Mwaniki D, Magnussen P, et al. Effects of multimicronutrient supplementation on helminth reinfection: a randomized, controlled trial in Kenyan schoolchildren. Trans R Soc Trop Med Hyg. 2003;97:109–114. [PubMed]
23. Borenstein M, Hedges LV, Higgins JPT, Rothstein HR. A basic introduction to fixed effect and random effects models for meta-analysis. Research Synthesis Methods. 2010;1:97–111.
24. Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21:1539–1558. [PubMed] 25. Higgins JP. Commentary: Heterogeneity in meta-analysis should be expected and appropriately quantified. Int J Epidemiol. 2008;37:1158–1160. [PubMed] 26. Knobloch K, Yoon U, Vogt PM. Preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement and publication bias. J Craniomaxillofac Surg. 2011;39:91–92. [PubMed]
27. Hill RB. Hookworm reinfestation in sanitated and unsanitated areas. Southern Med J. 1925;18:665–668.
28. Otto GF, Cort WW. Further studies on post-treatment reinfection with Ascaris in the United States. J Parasitol. 1934;20:245–247.
29. Pan CT, Ritchie LS, Hunter GW., 3rd Reinfection and seasonal fluctuations of Ascaris lumbricoides among a group of children in an area where night soil is used. J Parasitol. 1954;40:603–608. [PubMed] 30. Arfaa F, Ghadirian E. Epidemiology and mass-treatment of ascariasis in six rural communities in central Iran. Am J Trop Med Hyg. 1977;26:866–871. [PubMed] 31. Sinniah B. Prevalence, treatment and reinfection of intestinal helminths among schoolchildren in Kuala Lumpur, Malaysia. Public Health. 1984;98:38–42. [PubMed] 32. Haswell-Elkins MR, Elkins DB, Manjula K, Michael E, Anderson RM. An investigation of hookworm infection and reinfection following mass anthelmintic treatment in the south Indian fishing community of Vairavankuppam. Parasitology. 1988;96:565–577. [PubMed] 33. Elkins DB, Haswell-Elkins M, Anderson RM. The importance of host age and sex to patterns of reinfection with Ascaris lumbricoides following mass anthelmintic treatment in a South Indian fishing community. Parasitology. 1988;96:171–184. [PubMed] 34. Chan L, Kan SP, Bundy DA. The effect of repeated chemotherapy on the prevalence and intensity of Ascaris lumbricoides and Trichuris trichiura infection. Southeast Asian J Trop Med Public Health. 1992;23:228–234. [PubMed] 35. Quinnell RJ, Slater AF, Tighe P, Walsh EA, Keymer AE, et al. Reinfection with hookworm after chemotherapy in Papua New Guinea. Parasitology. 1993;106:379–385. [PubMed] 36. Albonico M, Smith PG, Ercole E, Hall A, Chwaya HM, et al. Rate of reinfection with intestinal nematodes after treatment of children with mebendazole or albendazole in a highly endemic area. Trans R Soc Trop Med Hyg. 1995;89:538–541. [PubMed] 37. Muennoo C, Achwanichkul W, Sa-nguankiat S, Pubampen S, Maipanich W, et al. The impact of primary health care intervention on reinfection of soil-transmitted helminths in the community. Southeast Asian J Trop Med Public Health. 1997;28:816–819. [PubMed] 38. Paul I, Gnanamani G, Nallam NR. Intestinal helminth infections among school children in Visakhapatnam. Indian J Pediatr. 1999;66:669–673. [PubMed] 39. Hagel I, Lynch NR, Di Prisco MC, Perez M, Sanchez JE, et al. Helminthic infection and anthropometric indicators in children from a tropical slum: Ascaris reinfection after anthelmintic treatment. J Trop Pediatr. 1999;45:215–220. [PubMed] 40. Albonico M, Stoltzfus RJ, Savioli L, Chwaya HM, d'Harcourt E, et al. A controlled evaluation of two school-based anthelminthic chemotherapy regimens on intensity of intestinal helminth infections. Int J Epidemiol. 1999;28:591–596. [PubMed]
41. Han GT, Han N, Qiao L, Li Y. Infection status of intestinal helminths after chemotherapy in school children living in the vegetable planting area of Shenqiu county. Chin J School Health. 2003;24:358. (in Chinese)
42. Saathoff E, Olsen A, Kvalsvig JD, Appleton CC. Patterns of geohelminth infection, impact of albendazole treatment and re-infection after treatment in schoolchildren from rural KwaZulu-Natal/South-Africa. BMC Infect Dis. 2004;4:27. [PMC free article] [PubMed]
43. Fei YL, Xu F, Wang ZP. Longitudinal study on Ascaris infection in town or village pupils in Fengxian. Chin J School Doctor. 2006;20:522–523. (in Chinese)
44. Liu CY, Zeng XJ, Jiang WS, Chen HG, Hong XL, et al. Reinfection after different chemotherapy measures carried out in heavy epidemic areas with Ascaris lumbricoides. J Pathog Biol. 2006;1:449–451. (in Chinese)
45. Zhang Y, Koukounari A, Kabatereine N, Fleming F, Kazibwe F, et al. Parasitological impact of 2-year preventive chemotherapy on schistosomiasis and soil-transmitted helminthiasis in Uganda. BMC Med. 2007;5:27. [PMC free article] [PubMed] 46. Nchito M, Geissler PW, Mubila L, Friis H, Olsen A. The effect of iron and multi-micronutrient supplementation on Ascaris lumbricoides reinfection among Zambian schoolchildren. Trans R Soc Trop Med Hyg. 2009;103:229–236. [PubMed] 47. Appleton CC, Mosala TI, Levin J, Olsen A. Geohelminth infection and re-infection after chemotherapy among slum-dwelling children in Durban, South Africa. Ann Trop Med Parasitol. 2009;103:249–261. [PubMed] 48. Cabrera BD. Reinfection and infection rates of ascariasis in relation to seasonal variation in the Philippines. Southeast Asian J Trop Med Public Health. 1984;15:394–401. [PubMed] 49. Bundy DAP, Cooper ES, Thompson DE, Didier JM, Simmons I. Effect of age and initial infection intensity on the rate of reinfection with Trichuris trichiura after treatment. Parasitology. 1988;97:469–476. [PubMed] 50. Henry FJ. Reinfection with Ascaris lumbricoides after chemotherapy: a comparative study in three villages with varying sanitation. Trans R Soc Trop Med Hyg. 1988;82:460–464. [PubMed] 51. Soeripto N. Reinfection and infection rates of soil-transmitted-helminths in Kemiri Sewu, Yogyakarta, Indonesia. Southeast Asian J Trop Med Public Health. 1991;22:216–221. [PubMed] 52. Hall A, Anwar KS, Tomkins AM. Intensity of reinfection with Ascaris lumbricoides and its implications for parasite control. Lancet. 1992;339:1253–1257. [PubMed] 53. Henry FJ, Huttly SR, Ahmed MU, Alam A. Effect of chemotherapy on helminth reinfection in slums and villages in Bangladesh. Southeast Asian J Trop Med Public Health. 1993;24:307–312. [PubMed] 54. Narain K, Medhi GK, Rajguru SK, Mahanta J. Cure and reinfection patterns of geohelminthic infections after treatment in communities inhabiting the tropical rainforest of Assam, India. Southeast Asian J Trop Med Public Health. 2004;35:512–517. [PubMed] 55. Schad GA, Anderson RM. Predisposition to hookworm infection in humans. Science. 1985;228:1537–1540. [PubMed] 56. Haswell-Elkins MR, Elkins DB, Anderson RM. Evidence for predisposition in humans to infection with Ascaris, hookworm, Enterobius and Trichuris in a South Indian fishing community. Parasitology. 1987;95:323–337. [PubMed] 57. Hlaing T, Saw T, Lwin M. Reinfection of people with Ascaris lumbricoides following single, 6-month and 12-month interval mass chemotherapy in Okpo village, rural Burma. Trans R Soc Trop Med Hyg. 1987;81:140–146. [PubMed] 58. Bundy DAP, Cooper ES, Thompson DE, Didier JM, Simmons I. Epidemiology and population dynamics of Ascaris lumbricoides and Trichuris trichiura infection in the same community. Trans R Soc Trop Med Hyg. 1987;81:987–993. [PubMed] 59. Bundy DAP, Cooper ES, Thompson DE, Didier JM, Anderson RM, et al. Predisposition to Trichuris trichiura infection in humans. Epidemiol Infect. 1987;98:65–71. [PMC free article] [PubMed] 60. Bundy DAP, Cooper ES. The evidence for predisposition to trichuriasis in humans: comparison of institutional and community studies. Ann Trop Med Parasitol. 1988;82:251–256. [PubMed] 61. Forrester JE, Scott ME, Bundy DAP, Golden MHN. Predisposition of individuals and families in Mexico to heavy infection with Ascaris lumbricoides and Trichuris trichiura. Trans R Soc Trop Med Hyg. 1990;84:272–276. [PubMed] 62. Bradley M, Chandiwana SK. Age-dependency in predisposition to hookworm infection in the Burma valley area of Zimbabwe. Trans R Soc Trop Med Hyg. 1990;84:826–828. [PubMed] 63. Upatham ES, Viyanant V, Brockelman WY, Kurathong S, Ardsungnoen P, et al. Predisposition to reinfection by intestinal helminths after chemotherapy in south Thailand. Int J Parasitol. 1992;22:801–806. [PubMed] 64. Haswell-Elkins M, Elkins D, Anderson RM. The influence of individual, social group and household factors on the distribution of Ascaris lumbricoides within a community and implications for control strategies. Parasitology. 1989;98:125–134. [PubMed] 65. Chai JY, Seo BS, Lee SH, Cho SY. Epidemiological studies on Ascaris lumbricoides reinfection in rural communities in Korea II. Age-specific reinfection rates and familial aggregation of the reinfected cases. Korean J Parasitol. 1983;21:142–149. [PubMed] 66. Imai J, Sakamoto O, Munthe FE, Sinulingga S. Survey for soil-transmitted helminths in Asahan Regency, North Sumatra, Indonesia. Southeast Asian J Trop Med Public Health. 1985;16:441–446. [PubMed]
67. Peng YK. Rate of reinfection with Ascaris after combination chemotherapy of albendazole and mebendazole. Chin J of Schisto Contr. 2001;13:156. (in Chinese)
68. Payne LG, Koski KG, Ortega-Barria E, Scott ME. Benefit of vitamin A supplementation on Ascaris reinfection is less evident in stunted children. J Nutr. 2007;137:1455–1459. [PubMed] 69. Nga TT, Winichagoon P, Dijkhuizen MA, Khan NC, Wasantwisut E, et al. Multi-micronutrient-fortified biscuits decreased prevalence of anemia and improved micronutrient status and effectiveness of deworming in rural Vietnamese school children. J Nutr. 2009;139:1013–1021. [PubMed]
70. Feng XP, Wang XH, Ni JF, Wu FX, Zhang FH. Observations on the effect of some measures for preventing intestinal helminth infection in soldiers. J Prev Med Chin PLA (People's Libration Army) 2000;18:210–211. (in Chinese)
71. Xu LQ, Xiao DH, Zhou CH, Zhang XQ, Lan SG, et al. On cleanliness of hands in diminution of Ascaris lumbricoides infection in children. Chin J Parasit Dis Contr. 2001;19:294–297. (in Chinese) [PubMed] 72. Louba AI, Geissler PW, Estambale B, Ouma J, Alusala D, et al. Earth-eating and reinfection with intestinal helminths among pregnant and lactating women in western Kenya. Trop Med Int Health. 2005;10:220–227. [PubMed]
73. Cort WW, Schapiro L, Stoll NR. A study of reinfection after treatment with hookworm and Ascaris in two villages in Panama. Am J Epidemiol. 1929;10:614–625.
74. Albonico M, Smith PG, Hall A, Chwaya HM, Alawi KS, et al. A randomized controlled trial comparing mebendazole and albendazole against Ascaris, Trichuris and hookworm infections. Trans R Soc Trop Med Hyg. 1994;88:585–589. [PubMed] 75. Pritchard DI, Quinnell RJ, Slater AF, McKean PG, Dale DD, et al. Epidemiology and immunology of Necator americanus infection in a community in Papua New Guinea: humoral responses to excretory-secretory and cuticular collagen antigens. Parasitology. 1990;100:317–326. [PubMed] 76. Elkins DB, Haswell-Elkins M, Anderson RM. The epidemiology and control of intestinal helminths in the Pulicat Lake region of Southern India. I. Study design and pre- and post-treatment observations on Ascaris lumbricoides infection. Trans R Soc Trop Med Hyg. 1986;80:774–792. [PubMed] 77. Hunter GW, 3rd, Hodges EP, et al. Studies of Schistosomiasis: II Summary of further studies on methods of recovering eggs of S. japonicum from stools. Bull U S Army Med Dep. 1948;8:128–131. [PubMed]
78. Hill RB. Investigations on the control of hookworm disease. XXV. The use of the egg-counting method in an intensive campaign. Am J Epidemiol. 1923;3:37–60.
79. King CH, Dickman K, Tisch DJ. Reassessment of the cost of chronic helmintic infection: a meta-analysis of disability-related outcomes in endemic schistosomiasis. Lancet. 2005;365:1561–1569. [PubMed] 80. Molyneux DH, Hotez PJ, Fenwick A. “Rapid-impact interventions”: how a policy of integrated control for Africa's neglected tropical diseases could benefit the poor. PLoS Med. 2005;2:e336. [PMC free article] [PubMed]
81. WHO. Prevention and control of schistosomiasis and soil-transmitted helminthiasis: report of a WHO expert committee. Geneva: World Health Organization; 2002.
82. Savioli L, Gabrielli AF, Montresor A, Chitsulo L, Engels D. Schistosomiasis control in Africa: 8 years after World Health Assembly Resolution 54.19. Parasitology. 2009;136:1677–1681. [PubMed] 83. Gungoren B, Latipov R, Regallet G, Musabaev E. Effect of hygiene promotion on the risk of reinfection rate of intestinal parasites in children in rural Uzbekistan. Trans R Soc Trop Med Hyg. 2007;101:564–569. [PubMed] 84. Anderson RM. The population dynamics and epidemiology of intestinal nematode infections. Trans R Soc Trop Med Hyg. 1986;80:686–696. [PubMed] 85. Levecke B, Speybroeck N, Dobson RJ, Vercruysse J, Charlier J. Novel insights in the fecal egg count reduction test for monitoring drug efficacy against soil-transmitted helminths in large-scale treatment programs. PLoS Negl Trop Dis. 2011;5:e1427. [PMC free article] [PubMed] 86. Montresor A. Cure rate is not a valid indicator for assessing drug efficacy and impact of preventive chemotherapy interventions against schistosomiasis and soil-transmitted helminthiasis. Trans R Soc Trop Med Hyg. 2011;105:361–363. [PubMed] 87. Vercruysse J, Behnke JM, Albonico M, Ame SM, Angebault C, et al. Assessment of the anthelmintic efficacy of albendazole in school children in seven countries where soil-transmitted helminths are endemic. PLoS Negl Trop Dis. 2011;5:e948. [PMC free article] [PubMed] 88. Asaolu SO, Ofoezie IE. The role of health education and sanitation in the control of helminth infections. Acta Trop. 2003;86:283–294. [PubMed] 89. Spiegel JM, Dharamsi S, Wasan KM, Yassi A, Singer B, et al. Which new approaches to tackling neglected tropical diseases show promise? PLoS Med. 2010;7:e1000255. [PMC free article] [PubMed] 90. King CH, Olbrych SK, Soon M, Singer ME, Carter J, et al. Utility of repeated praziquantel dosing in the treatment of schistosomiasis in high-risk communities in Africa: a systematic review. PLoS Negl Trop Dis. 2011;5:e1321. [PMC free article] [PubMed]
91. Vercruysse J, Albonico M, Behnke JM, Kotze AC, Prichard RK, et al. Is anthelmintic resistance a concern for the control of human soil-transmitted helminths? International J for Parasitology: Drugs and Drug Resistance. 2011;1:14–27.
92. Parker M, Allen T. Does mass drug administration for the integrated treatment of neglected tropical diseases really work? Assessing evidence for the control of schistosomiasis and soil-transmitted helminths in Uganda. Health Res Policy Syst. 2011;9:3. [PMC free article] [PubMed]
93. WHO. Guildelines for the evaluation of soil-transmitted helminthiasis and schistosomiasis at community level. WHO/CTD/SIP/98.1. Geneva: World Health Organization; 1998.
94. WHO. Monitoring helminth control programmes aimed at reducing morbidity caused by soil-transmitted helminths and schistosomes, with particular reference to school-age children. WHO/CDS/CPC/SIP/99.3. Geneva: World Health Organization; 1999.
95. Montresor A, Cong DT, Sinuon M, Tsuyuoka R, Chanthavisouk C, et al. Large-scale preventive chemotherapy for the control of helminth infection in Western Pacific countries: six years later. PLoS Negl Trop Dis. 2008;2:e278. [PMC free article] [PubMed] 96. Urbani C, Palmer K. Drug-based helminth control in Western Pacific countries: a general perspective. Trop Med Int Health. 2001;6:935–944. [PubMed] 97. Geerts S, Gryseels B. Drug resistance in human helminths: current situation and lessons from livestock. Clin Microbiol Rev. 2000;13:207–222. [PMC free article] [PubMed]
98. Crompton DWT, Savioli L. Handbook of helminth for public health. Boca Ration, USA: CRC Press; 2007.
99. Kobayashi J, Jimba M, Okabayashi H, Singhasivanon P, Waikagul J. Beyond deworming: the promotion of school-health-based interventions by Japan. Trends Parasitol. 2007;23:25–29. [PubMed] 100. Nock IH, Aken'ova T, Galadima M. Deworming: adding public health education to the equation. Trends Parasitol. 2006;22:7–8. [PubMed] 101. Allen T, Parker M. Will increased funding for neglected tropical diseases really make poverty history? Lancet. 2012 (in press). DOI: 10.1016/S0140-6736(12)60159-7. [PubMed] 102. Lammie PJ, Fenwick A, Utzinger J. A blueprint for success: integration of neglected tropical disease control programmes. Trends Parasitol. 2006;22:313–321. [PubMed] 103. Hong ST, Chai JY, Choi MH, Huh S, Rim HJ, et al. A successful experience of soil-transmitted helminth control in the Republic of Korea. Korean J Parasitol. 2006;44:177–185. [PMC free article] [PubMed] 104. Holveck JC, Ehrenberg JP, Ault SK, Rojas R, Vasquez J, et al. Prevention, control, and elimination of neglected diseases in the Americas: pathways to integrated, inter-programmatic, inter-sectoral action for health and development. BMC Public Health. 2007;7:6. [PMC free article] [PubMed]