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Logo of neurologyNeurologyAmerican Academy of Neurology
 
Neurology. May 1, 2012; 78(18): 1434–1440.
PMCID: PMC3345785
Cognitive performance of GBA mutation carriers with early-onset PD
The CORE-PD study
R.N. Alcalay, MD, MSc,corresponding author
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  • NONE
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  • NONE
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  • NONE
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  • NONE
Research Support, Government Entities:
  • NIH KL2 RR024157 Trainee
Research Support, Academic Entities:
  • NONE
Research Support, Foundations and Societies:
  • 1. The Brookdale Foundation 2.The Michael J Fox Foundation
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  • NONE
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  • NONE
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E. Caccappolo, PhD,
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
H. Mejia-Santana, MSc,
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
Employment, Commercial Entity:
  • NONE
Consultancies:
  • NONE
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  • NONE
Other Activities:
  • NONE
Clinical Procedures or Imaging Studies:
  • NONE
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  • NONE
Research Support, Government Entities:
  • NONE
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  • NONE
Research Support, Foundations and Societies:
  • NONE
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  • NONE
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  • NONE
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M.-X. Tang, PhD,
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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L. Rosado, MD,
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
Research Support, Government Entities:
  • NONE
Research Support, Academic Entities:
  • NONE
Research Support, Foundations and Societies:
  • NONE
Stock/Stock Options/Board of Directors Compensation:
  • NONE
License Fee Payments, Technology or Inventions:
  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
M. Orbe Reilly, MD,
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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D. Ruiz, BSc,
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  • NONE
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  • NONE
Employment, Commercial Entity:
  • NONE
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  • NONE
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  • NONE
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  • NONE
Clinical Procedures or Imaging Studies:
  • NONE
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  • NONE
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  • NONE
Research Support, Academic Entities:
  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
B. Ross, BSc,
Scientific Advisory Boards:
  • NONE
Gifts:
  • NONE
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  • NONE
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  • NONE
Patents:
  • NONE
Publishing Royalties:
  • NONE
Employment, Commercial Entity:
  • Montefiore Medical Center, North Division; Dept. of Oncology, technician
Consultancies:
  • NONE
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  • NONE
Other Activities:
  • NONE
Clinical Procedures or Imaging Studies:
  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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  • NONE
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M. Verbitsky, PhD,
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  • NONE
Employment, Commercial Entity:
  • NONE
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  • NONE
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  • NONE
Other Activities:
  • NONE
Clinical Procedures or Imaging Studies:
  • NONE
Research Support, Commercial Entities:
  • NONE
Research Support, Government Entities:
  • NONE
Research Support, Academic Entities:
  • NONE
Research Support, Foundations and Societies:
  • NONE
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  • NONE
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S. Kisselev, MS,
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  • NONE
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  • NONE
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  • NONE
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  • NONE
Employment, Commercial Entity:
  • NONE
Consultancies:
  • NONE
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  • NONE
Other Activities:
  • NONE
Clinical Procedures or Imaging Studies:
  • NONE
Research Support, Commercial Entities:
  • NONE
Research Support, Government Entities:
  • NONE
Research Support, Academic Entities:
  • NONE
Research Support, Foundations and Societies:
  • NONE
Stock/Stock Options/Board of Directors Compensation:
  • NONE
License Fee Payments, Technology or Inventions:
  • NONE
Royalty Payments, Technology or Inventions:
  • NONE
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  • NONE
Stock/Stock Options, Medical Equipment & Materials:
  • NONE
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  • NONE
E. Louis, MD, MSc,
Scientific Advisory Boards:
  • Dr. Louis previously served on a Data Safety Monitoring Board for Pfizer.
Gifts:
  • NONE
Funding for Travel or Speaker Honoraria:
  • NONE
Editorial Boards:
  • NONE
Patents:
  • NONE
Publishing Royalties:
  • NONE
Employment, Commercial Entity:
  • NONE
Consultancies:
  • NONE
Speakers’ Bureaus:
  • NONE
Other Activities:
  • NONE
Clinical Procedures or Imaging Studies:
  • NONE
Research Support, Commercial Entities:
  • NONE
Research Support, Government Entities:
  • NINDS R01 NS42859, NINDS R01 NS39422,NINDS T32 NS07153-24, NIA 2P01 AG0027232-16, NINDS R01 NS36630 (All 2007 - 2009)
Research Support, Academic Entities:
  • NONE
Research Support, Foundations and Societies:
  • Parkinson’s Disease Foundation (2007 - 2009)
Stock/Stock Options/Board of Directors Compensation:
  • NONE
License Fee Payments, Technology or Inventions:
  • NONE
Royalty Payments, Technology or Inventions:
  • NONE
Stock/Stock Options, Research Sponsor:
  • NONE
Stock/Stock Options, Medical Equipment & Materials:
  • NONE
Legal Proceedings:
  • NONE
C. Comella, MD,
Scientific Advisory Boards:
  • 1. Commercial: Allergan, Ipsen, Merz, NuPathe, Esai, UCB
Gifts:
  • NONE
Funding for Travel or Speaker Honoraria:
  • NONE
Editorial Boards:
  • Sleep Medicine editorial board for 6 years
Patents:
  • NONE
Publishing Royalties:
  • Uptodate (Kluwer Bucy) Cambridge publishing
Employment, Commercial Entity:
  • NONE
Consultancies:
  • Allergan Ipsen Esai Merz UCB
Speakers’ Bureaus:
  • NONE
Other Activities:
  • NONE
Clinical Procedures or Imaging Studies:
  • NONE
Research Support, Commercial Entities:
  • Commercial: Allergan, Ipsen, Merz, Merk-Serono Non-Commercial: NIH
Research Support, Government Entities:
  • NONE
Research Support, Academic Entities:
  • NONE
Research Support, Foundations and Societies:
  • NONE
Stock/Stock Options/Board of Directors Compensation:
  • NONE
License Fee Payments, Technology or Inventions:
  • NONE
Royalty Payments, Technology or Inventions:
  • NONE
Stock/Stock Options, Research Sponsor:
  • NONE
Stock/Stock Options, Medical Equipment & Materials:
  • NONE
Legal Proceedings:
  • NONE
A. Colcher, MD,
Scientific Advisory Boards:
  • NONE
Gifts:
  • NONE
Funding for Travel or Speaker Honoraria:
  • Lundbeck pharmaceuticals: speaker honoraria TEVA pharmaceuticals: Speaker honoraria
Editorial Boards:
  • NONE
Patents:
  • NONE
Publishing Royalties:
  • NONE
Employment, Commercial Entity:
  • University of Pennsylvania
Consultancies:
  • UBC: development of training video for UPDRS and UMSARS Speakers’ Bureaus: Lundbeck TEVA Merz Guidepoint global
Speakers’ Bureaus:
  • NONE
Other Activities:
  • NONE
Clinical Procedures or Imaging Studies:
  • NONE
Research Support, Commercial Entities:
  • NONE
Research Support, Government Entities:
  • NONE
Research Support, Academic Entities:
  • NONE
Research Support, Foundations and Societies:
  • NONE
Stock/Stock Options/Board of Directors Compensation:
  • NONE
License Fee Payments, Technology or Inventions:
  • NONE
Royalty Payments, Technology or Inventions:
  • NONE
Stock/Stock Options, Research Sponsor:
  • NONE
Stock/Stock Options, Medical Equipment & Materials:
  • NONE
Legal Proceedings:
  • NONE
D. Jennings, MD,
Scientific Advisory Boards:
  • Data Safety and Monitoring Board; Genzyme Speakers’ Bureaus:; Lundbeck; Teva
Gifts:
  • NONE
Funding for Travel or Speaker Honoraria:
  • NONE
Editorial Boards:
  • NONE
Patents:
  • NONE
Publishing Royalties:
  • NONE
Employment, Commercial Entity:
  • NONE
Consultancies:
  • NONE
Speakers’ Bureaus:
  • NONE
Other Activities:
  • NONE
Clinical Procedures or Imaging Studies:
  • NONE
Research Support, Commercial Entities:
  • NONE
Research Support, Government Entities:
  • NONE
Research Support, Academic Entities:
  • NONE
Research Support, Foundations and Societies:
  • NONE
Stock/Stock Options/Board of Directors Compensation:
  • NONE
License Fee Payments, Technology or Inventions:
  • NONE
Royalty Payments, Technology or Inventions:
  • NONE
Stock/Stock Options, Research Sponsor:
  • NONE
Stock/Stock Options, Medical Equipment & Materials:
  • NONE
Legal Proceedings:
  • NONE
M. Nance, MD,
Scientific Advisory Boards:
  • Parkinson Study Group Scientific Review Committee
Gifts:
  • NONE
Funding for Travel or Speaker Honoraria:
  • Augsburg College honorarium for lecture travel expenses to serve as speaker at World Congress on HD, HDSA national convention
Editorial Boards:
  • NONE
Patents:
  • NONE
Publishing Royalties:
  • Juvenile Huntington’s Disease and other trinucleotide repeat disorders, Oxford University Press, 2009
Employment, Commercial Entity:
  • son has worked summer jobs at Access Genetics as an IT tech Speakers’ Bureaus: spouse on speaker’s bureau for Genentech and Schering- Plough
Consultancies:
  • NONE
Speakers’ Bureaus:
  • NONE
Other Activities:
  • NONE
Clinical Procedures or Imaging Studies:
  • NONE
Research Support, Commercial Entities:
  • Schwarz Biosciences Inc Neurosearch Sweden IMPAX Pharmaceuticals Medivation Inc Neuraltus Pharmaceuticals Teva Pharmaceuticals Teva Neuroscience Juvantia Pharmaceuticals
Research Support, Government Entities:
  • NINDS 5 U10 NS044466-05 2008-2010 site PI NINDS 5 RO1 NS36630 2004-2009 site PI NINDS 2 RO1 NS640068-08 2001-2013 site PI, Steering Committee, Recruitment Committee, Ethics Committee NHGRI/NINDS HG02449-07 2002-2010 site PI NINDS 1RO1 NS052592-01 2005-2010 site PI NINDS RO1 NS060228-01A1 2008-2011 site PI NCCAM site PI
Research Support, Academic Entities:
  • NONE
Research Support, Foundations and Societies:
  • National Parkinson Foundation Huntington Disease Society of America Michael J. Fox Foundation Northwestern Dixon Foundation
Stock/Stock Options/Board of Directors Compensation:
  • NONE
License Fee Payments, Technology or Inventions:
  • NONE
Royalty Payments, Technology or Inventions:
  • NONE
Stock/Stock Options, Research Sponsor:
  • NONE
Stock/Stock Options, Medical Equipment & Materials:
  • NONE
Legal Proceedings:
  • NONE
S. Bressman, MD,
Scientific Advisory Boards:
  • Scientific Advisory Board of Bachmann Strauss Dystonia and Parkinsons’s Foundation and; Michael J Fox Foundation for Parkinson’s Research; Dystonia Medical Research Foundation
Gifts:
  • NONE
Funding for Travel or Speaker Honoraria:
  • NONE
Editorial Boards:
  • NONE
Patents:
  • THAP1 gene testing
Publishing Royalties:
  • NONE
Employment, Commercial Entity:
  • NONE
Consultancies:
  • NONE
Speakers’ Bureaus:
  • NONE
Other Activities:
  • NONE
Clinical Procedures or Imaging Studies:
  • NONE
Research Support, Commercial Entities:
  • NONE
Research Support, Government Entities:
  • NIH (5 U01 NS050095-02) 09/01/2005 – 12/31/2010, co- investigator NIH (2 P50 NS037409-10) 12/01/09-11/30/2014 , consultant
Research Support, Academic Entities:
  • NONE
Research Support, Foundations and Societies:
  • Michael J Fox Foundation for Parkinson’s Research
Stock/Stock Options/Board of Directors Compensation:
  • NONE
License Fee Payments, Technology or Inventions:
  • NONE
Royalty Payments, Technology or Inventions:
  • NONE
Stock/Stock Options, Research Sponsor:
  • NONE
Stock/Stock Options, Medical Equipment & Materials:
  • NONE
Legal Proceedings:
  • NONE
W.K. Scott, PhD,
Scientific Advisory Boards:
  • NONE
Gifts:
  • NONE
Funding for Travel or Speaker Honoraria:
  • NONE
Editorial Boards:
  • NONE
Patents:
  • 1. Co-inventor of patent regarding use of genetic data for risk assessment in age related macular degeneration, licensed by ArcticDx.
Publishing Royalties:
  • NONE
Employment, Commercial Entity:
  • NONE
Consultancies:
  • NONE
Speakers’ Bureaus:
  • NONE
Other Activities:
  • NONE
Clinical Procedures or Imaging Studies:
  • NONE
Research Support, Commercial Entities:
  • NONE
Research Support, Government Entities:
  • NIH grants NS071674 (co-investigator 2010-), HG000026 (PI, 2010-), NS039764 (co-investigator 2009-2011), AI068804 (subcontract PI, 2007-), AG019085 (co- investigator 2006-), EY12118 (co-investigator 2000-), and Florida Biomedical Research Program grant (co- investigator 2009-)
Research Support, Academic Entities:
  • NONE
Research Support, Foundations and Societies:
  • NONE
Stock/Stock Options/Board of Directors Compensation:
  • NONE
License Fee Payments, Technology or Inventions:
  • Patent on use of genetic data for prediction of AMD risk, licensed to ArcticDx.
Royalty Payments, Technology or Inventions:
  • NONE
Stock/Stock Options, Research Sponsor:
  • NONE
Stock/Stock Options, Medical Equipment & Materials:
  • NONE
Legal Proceedings:
  • NONE
C. Tanner, MD, PhD,
Scientific Advisory Boards:
  • A. DSMB Service:; NIH, NINDS, 2006-Present, Member, Data Monitoring Committee, 2CARE HD, NINDS; Michael J Fox Foundation, 2009-Present, Chair,Data Monitoring Committee, SURE-PD Trial of Inosine in Parkinson’s Disease, Parkinson Study Group/MJFF; Micahel J Fox Foundation, 2009-Present, Chair,Data Monitoring Committee, Validation of Dyskinesia Rating Scales Study, MJFF B. Scientific Advisory Board Service; 2001 - Present, Scientific Advisory Board, Michael J. Fox Foundation; 2006 – Present, Scientific Advisory Board, Arizona Parkinson’s Disease Consortium(APDC); 2007 - Present, Scientific Advisory Board, Spasmodic Dysphonia Association
Gifts:
  • NONE
Funding for Travel or Speaker Honoraria:
  • Movement Disorders Society, Travel reimbursement & speaker honoraria (2009, 2011); American Academy of Neurology, Speaker Honorarium & travel reimbursement (2009 annual meeting); World Federation of Neurology, Travel reimbursement & speaker honoraria (2009, 2011); NIH, NINDS, Travel reimbursement & speaker honoraria (2009, 2010); World Parkinson’s Disease Congress, Travel reimbursement & speaker honorarium (2006, 2010); Parkinson’s Action Network , Travel reimbursement & speaker honoraria; ; Harvard NeuroDiscovery Center Travel reimbursement & speaker honorarium; ; Michael J Fox Foundation Travel & speaker honorarium;
Editorial Boards:
  • Journal of Parkinson’s Disease , Editorial Board , 2010 - present
Patents:
  • NONE
Publishing Royalties:
  • NONE
Employment, Commercial Entity:
  • 1990 - Present, Parkinson’s Institute and Clinical Center, Director, Clinical Research; 2006 – 2009, Special Government Employeee,NIH, NINDS, Member, National Advisory Council Neurological Disorders and Stroke (NANDS)
Consultancies:
  • Stanford University (consultant on Muscular Dystrophy Association funded research); ; Pacific Health Research Institute (consultant on NIH & Department of Defense- funded research); ; SunHealth Research Institute (consultant on MJFF funded research); ; Impax Pharmaceuticals (2009 - present); Lundbeck Pharmaceuticals; ; Adamas Pharmaceuticals - Consulting 2010- present; NeuroPace , Inc. - Consulting 2010
Speakers’ Bureaus:
  • NONE
Other Activities:
  • NONE
Clinical Procedures or Imaging Studies:
  • NONE
Research Support, Commercial Entities:
  • NONE
Research Support, Government Entities:
  • NINDS, NIH: NS36630, (PI: Marder, K.), Role: Site Investigator, 5/1/04 – 4/30/08; DOD: W81XWH-04-1-0490, Role: Principal Investigator, 4/1/04 – 3/1/13; AHRQ: R01 HS018413 , Role: Principal Investigator, 9/30/09 – 9/29/11; R01 NS046340-01A1,Role: Principal Investigator , 9/23/05 – 6/30/11; NINDS, NIH: U10 NS44465, Role: Principal Investigator, 2/1/08 – 11/30/12; DOD, W81XWH-07-1-0001 (PI: Trimble), Role: Co- investigator, 3/1/07 – 11/9/2012; DOD, W81XWH-07-1-0261, Role: Principal Investigator, 3/1/07 – 3/31/13; NIH, NIEHS, RO1 ES 017462, (PI: Checkoway), Role: Co-investigator 9/1/2009 – 8/31/2014 NINDS, NIH
Research Support, Academic Entities:
  • Parkinson’s Institute
Research Support, Foundations and Societies:
  • Parkinson’s Disease Foundation; Michael J. Fox Foundation; Brin Foundation; Parkinson Alliance (Unity Walk)
Stock/Stock Options/Board of Directors Compensation:
  • NONE
License Fee Payments, Technology or Inventions:
  • NONE
Royalty Payments, Technology or Inventions:
  • NONE
Stock/Stock Options, Research Sponsor:
  • NONE
Stock/Stock Options, Medical Equipment & Materials:
  • NONE
Legal Proceedings:
  • NONE
S. Mickel, MD,
Scientific Advisory Boards:
  • NONE
Gifts:
  • NONE
Funding for Travel or Speaker Honoraria:
  • NONE
Editorial Boards:
  • NONE
Patents:
  • NONE
Publishing Royalties:
  • NONE
Employment, Commercial Entity:
  • NONE
Consultancies:
  • NONE
Speakers’ Bureaus:
  • NONE
Other Activities:
  • NONE
Clinical Procedures or Imaging Studies:
  • NONE
Research Support, Commercial Entities:
  • NONE
Research Support, Government Entities:
  • NONE
Research Support, Academic Entities:
  • NONE
Research Support, Foundations and Societies:
  • NONE
Stock/Stock Options/Board of Directors Compensation:
  • NONE
License Fee Payments, Technology or Inventions:
  • NONE
Royalty Payments, Technology or Inventions:
  • NONE
Stock/Stock Options, Research Sponsor:
  • NONE
Stock/Stock Options, Medical Equipment & Materials:
  • NONE
Legal Proceedings:
  • NONE
H. Andrews, PhD,
Scientific Advisory Boards:
  • NONE
Gifts:
  • NONE
Funding for Travel or Speaker Honoraria:
  • NONE
Editorial Boards:
  • NONE
Patents:
  • NONE
Publishing Royalties:
  • NONE
Employment, Commercial Entity:
  • NONE
Consultancies:
  • NONE
Speakers’ Bureaus:
  • NONE
Other Activities:
  • NONE
Clinical Procedures or Imaging Studies:
  • NONE
Research Support, Commercial Entities:
  • ISC Ltd (see above)
Research Support, Government Entities:
  • I was supported by the following federally funded research projects during the past two years; my role on all projects was to head the coordination of data-related activities in my capacity as director of the Data Coordinating Center at the Columbia Mailman School of Public Health.; NICHD, National Children’s Study,NICHD contract to Mount Sinai School of Medicine; NIEHS, Health Effects of Early-Life Exposure to Urban Pollutants, 5R01ES013543; NCRR, Clinical & Translational Science Award, TL1RR24158; NICHD, Traumatic Brain Injury Clinical Trials Network, U01HD042823; NINDS, NY Columbia Collaborative SPOTRIAS, P50NS049060; NIA, Predictors of Severity in Alzheimer’s Disease, R01AG007370; NIEHS, Phthalate Exposure and Inner City Pediatric Asthma, R01ES014393; NINDS, MultiCenter ALS Cohort Study of Oxidative Stress, R13NS074853; NIMH, Optimizing Treatment for Complicated Grief, R01MH060783; NIA, White Matter Hyperintensities in Aging and Dementia, R01AG034189; Assess the Effects of ETS on Neurodevelopment, R01DA027100; NIA, Epidemiology of Biomarkers of Risk and Progression in Late Onset Alzheimer’s Disease, U24AG026395; NIEHS, Role of Airborne PAHs and DEP in Pathogenesis of Childhood Asthma, P50ES015905; NIA, Alzheimer’s Disease Research Center at Columbia University, P50AG008702
Research Support, Academic Entities:
  • NONE
Research Support, Foundations and Societies:
  • NONE
Stock/Stock Options/Board of Directors Compensation:
  • NONE
License Fee Payments, Technology or Inventions:
  • NONE
Royalty Payments, Technology or Inventions:
  • NONE
Stock/Stock Options, Research Sponsor:
  • NONE
Stock/Stock Options, Medical Equipment & Materials:
  • NONE
Legal Proceedings:
  • NONE
C. Waters, MD,
Scientific Advisory Boards:
  • NONE
Gifts:
  • NONE
Funding for Travel or Speaker Honoraria:
  • NONE
Editorial Boards:
  • NONE
Patents:
  • NONE
Publishing Royalties:
  • royalties for Book Diagnosis and Management of Parksinson’s disease
Employment, Commercial Entity:
  • NONE
Consultancies:
  • Commercial Entity Advisory board Teva Speakers’ Bureaus: Commercial Entity Teva Boehringer
Speakers’ Bureaus:
  • NONE
Other Activities:
  • NONE
Clinical Procedures or Imaging Studies:
  • NONE
Research Support, Commercial Entities:
  • Commercial entity Solvay UCB Novartis
Research Support, Government Entities:
  • NONE
Research Support, Academic Entities:
  • NONE
Research Support, Foundations and Societies:
  • NONE
Stock/Stock Options/Board of Directors Compensation:
  • NONE
License Fee Payments, Technology or Inventions:
  • NONE
Royalty Payments, Technology or Inventions:
  • NONE
Stock/Stock Options, Research Sponsor:
  • NONE
Stock/Stock Options, Medical Equipment & Materials:
  • NONE
Legal Proceedings:
  • NONE
S. Fahn, MD,
Scientific Advisory Boards:
  • RJG Foundation; IMPAX Pharmaceuticals; Lundbeck Pharmaceuticals; Intec Pharma; Merz Pharma;
Gifts:
  • NONE
Funding for Travel or Speaker Honoraria:
  • NONE
Editorial Boards:
  • Current Neurology and Neurosurgery Report, co-editor (annual)
Patents:
  • NONE
Publishing Royalties:
  • Principles and Practice of Movement Disorders, Elsevier, 2007
Employment, Commercial Entity:
  • NONE
Consultancies:
  • Civitas; Genervon Laboratories; Green Cross Corporation of Korea; Oxford Biomedica; GE Healthcare
Speakers’ Bureaus:
  • NONE
Other Activities:
  • NONE
Clinical Procedures or Imaging Studies:
  • NONE
Research Support, Commercial Entities:
  • NONE
Research Support, Government Entities:
  • NONE
Research Support, Academic Entities:
  • NONE
Research Support, Foundations and Societies:
  • Parkinson’s Disease Foundation (no salary support). Smart Family Foundation (no salary support).
Stock/Stock Options/Board of Directors Compensation:
  • NONE
License Fee Payments, Technology or Inventions:
  • NONE
Royalty Payments, Technology or Inventions:
  • NONE
Stock/Stock Options, Research Sponsor:
  • NONE
Stock/Stock Options, Medical Equipment & Materials:
  • NONE
Legal Proceedings:
  • Proctor-Goodwin law firm, consultant about history of a drug’s development, 2010
L. Cote, MD,
Scientific Advisory Boards:
  • NONE
Gifts:
  • NONE
Funding for Travel or Speaker Honoraria:
  • NONE
Editorial Boards:
  • NONE
Patents:
  • NONE
Publishing Royalties:
  • NONE
Employment, Commercial Entity:
  • NONE
Consultancies:
  • 1. Consultation fee from Teva Neuroscience
Speakers’ Bureaus:
  • NONE
Other Activities:
  • NONE
Clinical Procedures or Imaging Studies:
  • NONE
Research Support, Commercial Entities:
  • NONE
Research Support, Government Entities:
  • NONE
Research Support, Academic Entities:
  • NONE
Research Support, Foundations and Societies:
  • NONE
Stock/Stock Options/Board of Directors Compensation:
  • NONE
License Fee Payments, Technology or Inventions:
  • NONE
Royalty Payments, Technology or Inventions:
  • NONE
Stock/Stock Options, Research Sponsor:
  • NONE
Stock/Stock Options, Medical Equipment & Materials:
  • NONE
Legal Proceedings:
  • NONE
S. Frucht, MD,
Scientific Advisory Boards:
  • NONE
Gifts:
  • NONE
Funding for Travel or Speaker Honoraria:
  • Consulting for Jazz Pharmaceuticals, Lundbeck, Merz
Editorial Boards:
  • NONE
Patents:
  • NONE
Publishing Royalties:
  • Movement Disorders Emergencies
Employment, Commercial Entity:
  • American Academy of Neurology Movement Disorders Society
Consultancies:
  • UCB Pharma, consultant 2008 Jazz Pharma, consultant 2008 Merz Pharma, consultant 2010 GE Healthcare, consultant 2010 Allergan, consultant, 2009
Speakers’ Bureaus:
  • NONE
Other Activities:
  • NONE
Clinical Procedures or Imaging Studies:
  • NONE
Research Support, Commercial Entities:
  • NONE
Research Support, Government Entities:
  • NONE
Research Support, Academic Entities:
  • NONE
Research Support, Foundations and Societies:
  • NONE
Stock/Stock Options/Board of Directors Compensation:
  • NONE
License Fee Payments, Technology or Inventions:
  • NONE
Royalty Payments, Technology or Inventions:
  • NONE
Stock/Stock Options, Research Sponsor:
  • NONE
Stock/Stock Options, Medical Equipment & Materials:
  • NONE
Legal Proceedings:
  • NONE
B. Ford, MD,
Scientific Advisory Boards:
  • Medtronic, Inc
Gifts:
  • NONE
Funding for Travel or Speaker Honoraria:
  • NONE
Editorial Boards:
  • NONE
Patents:
  • NONE
Publishing Royalties:
  • NONE
Employment, Commercial Entity:
  • NONE
Consultancies:
  • NONE
Speakers’ Bureaus:
  • NONE
Other Activities:
  • NONE
Clinical Procedures or Imaging Studies:
  • NONE
Research Support, Commercial Entities:
  • NONE
Research Support, Government Entities:
  • NONE
Research Support, Academic Entities:
  • NONE
Research Support, Foundations and Societies:
  • NONE
Stock/Stock Options/Board of Directors Compensation:
  • NONE
License Fee Payments, Technology or Inventions:
  • NONE
Royalty Payments, Technology or Inventions:
  • NONE
Stock/Stock Options, Research Sponsor:
  • NONE
Stock/Stock Options, Medical Equipment & Materials:
  • NONE
Legal Proceedings:
  • NONE
M. Rezak, MD, PhD,
Scientific Advisory Boards:
  • NONE
Gifts:
  • NONE
Funding for Travel or Speaker Honoraria:
  • NONE
Editorial Boards:
  • NONE
Patents:
  • NONE
Publishing Royalties:
  • NONE
Employment, Commercial Entity:
  • I am hospital based neurologist at Central DuPage Hosital iun Winfield Illinois (not for profit) Speakers’ Bureaus: speaker bureau for Teva, Allergan, Medtronic, Merz, Novartis
Consultancies:
  • NONE
Speakers’ Bureaus:
  • NONE
Other Activities:
  • NONE
Clinical Procedures or Imaging Studies:
  • NONE
Research Support, Commercial Entities:
  • NONE
Research Support, Government Entities:
  • NONE
Research Support, Academic Entities:
  • NONE
Research Support, Foundations and Societies:
  • NONE
Stock/Stock Options/Board of Directors Compensation:
  • NONE
License Fee Payments, Technology or Inventions:
  • NONE
Royalty Payments, Technology or Inventions:
  • NONE
Stock/Stock Options, Research Sponsor:
  • NONE
Stock/Stock Options, Medical Equipment & Materials:
  • NONE
Legal Proceedings:
  • NONE
K. Novak, PhD,
Scientific Advisory Boards:
  • NONE
Gifts:
  • NONE
Funding for Travel or Speaker Honoraria:
  • NONE
Editorial Boards:
  • NONE
Patents:
  • NONE
Publishing Royalties:
  • NONE
Employment, Commercial Entity:
  • NONE
Consultancies:
  • NONE
Speakers’ Bureaus:
  • NONE
Other Activities:
  • NONE
Clinical Procedures or Imaging Studies:
  • NONE
Research Support, Commercial Entities:
  • Cyberonics, Inc.
Research Support, Government Entities:
  • NIH-NINDS R01.NS 366301031 to Karen Marder (study P.I.), sub-I, 2006-2010.; NIH-NINDS “Parkinson’s Disease Neuroprotection Clinical Trial: Clinical Centers.” (NET-PD), sub-I, 2006-current
Research Support, Academic Entities:
  • NONE
Research Support, Foundations and Societies:
  • NONE
Stock/Stock Options/Board of Directors Compensation:
  • NONE
License Fee Payments, Technology or Inventions:
  • NONE
Royalty Payments, Technology or Inventions:
  • NONE
Stock/Stock Options, Research Sponsor:
  • NONE
Stock/Stock Options, Medical Equipment & Materials:
  • NONE
Legal Proceedings:
  • NONE
J.H. Friedman, MD,
Scientific Advisory Boards:
  • Teva, EMD Serono, Acadia, Genzyme , Addex-- consultant
Gifts:
  • NONE
Funding for Travel or Speaker Honoraria:
  • Teva, Ingelheim Boehringer; Glaxo Smith Kline; United Biosource;Schwarz
Editorial Boards:
  • Medicine & Health/Rhode Island -- Editor-in-Chief; Parkinsonism & Related Disorders -- Editorial Board; Neurology Reviews -- Editorial Board
Patents:
  • NONE
Publishing Royalties:
  • Making the Connection Between Brain and Behavior: Coping with Parkinson’s Disease (Demos Health, 2007)
Employment, Commercial Entity:
  • Butler Hospital
Consultancies:
  • Acadia, Teva, EMD Serono, Addex; Genzyme -- consultant Speakers’ Bureaus: Teva, GlaxoSmithKline, Boehringer Ingelheim
Speakers’ Bureaus:
  • NONE
Other Activities:
  • NONE
Clinical Procedures or Imaging Studies:
  • NONE
Research Support, Commercial Entities:
  • Teva, Boehringer Ingelheim, Cephalon, Acadia,MJFox Fdn; -- Site PI
Research Support, Government Entities:
  • NIH R01 HG002449; R01 NS36630, U10 NS050095; R01 NS037167 -- Site PI Teva Azilect for cognition;Site PI; 2011-2012 Merck: Safinamide for PD; site PI; 2010-2011 Acadia:pimavanserin for psychosis in PD: site PI 2010-2012
Research Support, Academic Entities:
  • NONE
Research Support, Foundations and Societies:
  • Michael J. Fox Foundation -- Site PI
Stock/Stock Options/Board of Directors Compensation:
  • NONE
License Fee Payments, Technology or Inventions:
  • NONE
Royalty Payments, Technology or Inventions:
  • NONE
Stock/Stock Options, Research Sponsor:
  • NONE
Stock/Stock Options, Medical Equipment & Materials:
  • NONE
Legal Proceedings:
  • NONE
R. Pfeiffer, MD,
Scientific Advisory Boards:
  • National Parkinson Foundation
Gifts:
  • NONE
Funding for Travel or Speaker Honoraria:
  • See #9 Speakers Bureau (I really am not sure what you are asking for here)
Editorial Boards:
  • Parkinsonism and Related Disorders, Co-Editor in Chief 2008-present; Journal of Parkinson’s Disease, Editorial Board Member, 2011-present
Patents:
  • NONE
Publishing Royalties:
  • Parkinson’s Disease, Taylor & Francis, 2008-present; Parkinson’s Disease and Nonmotor Dysfunction, Humana, 2008-present; Neuro-Gastroenterology,Butterworth-Heinemann, 2008
Employment, Commercial Entity:
  • University of Tennessee Health Science Center; Semmes-Murphey Neurologic & Spine Institute
Consultancies:
  • Solvay; Theravance; Genactis; Schlesinger Associates 4)UCB Speakers’ Bureaus:; Boehringer-Ingelheim; Novartis; Teva
Speakers’ Bureaus:
  • NONE
Other Activities:
  • NONE
Clinical Procedures or Imaging Studies:
  • NONE
Research Support, Commercial Entities:
  • Novartis; Boehringer-Ingelheim; UCB/Schwarz; Santhera; Molecular Biometrics
Research Support, Government Entities:
  • NONE
Research Support, Academic Entities:
  • Columbia University (CORE-PD Study); Weill Cornell Medical College (QE3 Study); Northwestern University (STEADY-PD Study); Indiana University (PROGENI Study)
Research Support, Foundations and Societies:
  • Parkinson Study Group; Michael J Fox Foundation - (I did not receive funding directly from MJFF, but they provided funding for the STEADY-PD Study listed above)
Stock/Stock Options/Board of Directors Compensation:
  • NONE
License Fee Payments, Technology or Inventions:
  • NONE
Royalty Payments, Technology or Inventions:
  • NONE
Stock/Stock Options, Research Sponsor:
  • NONE
Stock/Stock Options, Medical Equipment & Materials:
  • NONE
Legal Proceedings:
  • Spriggs & Hollingsworth, consultant; Davis Graham and Stubbs, consultant; Tucker Ellis & West, consultant
L. Marsh, MD,
Scientific Advisory Boards:
  • Scientific Advisory Board-National Parkinson Foundation, American Parkinson’s Disease Association, Parkinson Study Group
Gifts:
  • NONE
Funding for Travel or Speaker Honoraria:
  • NONE
Editorial Boards:
  • Editorial Board: Journal of Parkinson’s Disease-2010-present
Patents:
  • NONE
Publishing Royalties:
  • Psychiatric Issues in Parkinson’s Disease: A Practical Guide, Taylor & Francis, Informa, 2005
Employment, Commercial Entity:
  • Current: Department of Veterans Affairs-Director, Mental Health Care Line, Michael E. DeBakey Veterans Affairs Medical Center; Current: Baylor College of Medicine, Professor; Prior: Johns Hopkins University - Associate Professor
Consultancies:
  • Merck Serono
Speakers’ Bureaus:
  • NONE
Other Activities:
  • NONE
Clinical Procedures or Imaging Studies:
  • NONE
Research Support, Commercial Entities:
  • Forest Research Institute Eli Lilly Boehringer-Ingelheim
Research Support, Government Entities:
  • NIH-R01 MH069666, PI, 2004-present NIH- P50 NS38377, PI-Clinical Core, 1998-2009 NIH- M032413, Site PI, 2004-2009 NIH R01 NS037167, Site PI, 2008-2009 NIH RO1 NS36630, Site PI, 2007-2009
Research Support, Academic Entities:
  • Baylor College of Medicine
Research Support, Foundations and Societies:
  • Michael J Fox Foundation
Stock/Stock Options/Board of Directors Compensation:
  • NONE
License Fee Payments, Technology or Inventions:
  • NONE
Royalty Payments, Technology or Inventions:
  • NONE
Stock/Stock Options, Research Sponsor:
  • NONE
Stock/Stock Options, Medical Equipment & Materials:
  • NONE
Legal Proceedings:
  • NONE
B. Hiner, MD,
Scientific Advisory Boards:
  • NONE
Gifts:
  • NONE
Funding for Travel or Speaker Honoraria:
  • NONE
Editorial Boards:
  • NONE
Patents:
  • NONE
Publishing Royalties:
  • NONE
Employment, Commercial Entity:
  • NONE
Consultancies:
  • NONE
Speakers’ Bureaus:
  • NONE
Other Activities:
  • NONE
Clinical Procedures or Imaging Studies:
  • NONE
Research Support, Commercial Entities:
  • NONE
Research Support, Government Entities:
  • NONE
Research Support, Academic Entities:
  • NONE
Research Support, Foundations and Societies:
  • NONE
Stock/Stock Options/Board of Directors Compensation:
  • NONE
License Fee Payments, Technology or Inventions:
  • NONE
Royalty Payments, Technology or Inventions:
  • NONE
Stock/Stock Options, Research Sponsor:
  • NONE
Stock/Stock Options, Medical Equipment & Materials:
  • NONE
Legal Proceedings:
  • NONE
A. Siderowf, MD, MSCE,
Scientific Advisory Boards:
  • Teva Neuroscience--advisory board Neuurosearch--DSMB Michael J Fox Foundation--DSMB
Gifts:
  • NONE
Funding for Travel or Speaker Honoraria:
  • Teva Neuroscience--speaker honoraria
Editorial Boards:
  • NONE
Patents:
  • NONE
Publishing Royalties:
  • NONE
Employment, Commercial Entity:
  • NONE
Consultancies:
  • Supernus Pharmaceuticals
Speakers’ Bureaus:
  • NONE
Other Activities:
  • NONE
Clinical Procedures or Imaging Studies:
  • NONE
Research Support, Commercial Entities:
  • Avid Radiopharmaceuticals, site PI, 2009-
Research Support, Government Entities:
  • 1) NINDS U10 NS044451-023; site PI 2010- 2) NINDS P50 NS053488-01; Project leader; 2007-2012 3) NINDS R43NS0636071; site PI, 10/1/08 to 9/31/10 4) NINDS R01NS065087; co Investigator 2010-2012
Research Support, Academic Entities:
  • NONE
Research Support, Foundations and Societies:
  • Institute for Neurodegenerative Disorders, site PI, 2007- 2011
Stock/Stock Options/Board of Directors Compensation:
  • NONE
License Fee Payments, Technology or Inventions:
  • NONE
Royalty Payments, Technology or Inventions:
  • NONE
Stock/Stock Options, Research Sponsor:
  • NONE
Stock/Stock Options, Medical Equipment & Materials:
  • NONE
Legal Proceedings:
  • Frost Brown Todd, consultant 2009-2010
H. Payami,
Scientific Advisory Boards:
  • NONE
Gifts:
  • NONE
Funding for Travel or Speaker Honoraria:
  • NONE
Editorial Boards:
  • NONE
Patents:
  • Method of identifying and treating a person having a predisposition to or afflicted with Parkinson’s disease
Publishing Royalties:
  • NONE
Employment, Commercial Entity:
  • NY state department of health, research scientist 8
Consultancies:
  • HRI, Inc. non-profit; an NIH funded grant to University of Vermont
Speakers’ Bureaus:
  • NONE
Other Activities:
  • NONE
Clinical Procedures or Imaging Studies:
  • NONE
Research Support, Commercial Entities:
  • NONE
Research Support, Government Entities:
  • National Institutes of Health, National Institute of Neurologic Disease and Stroke R01NS36960; National Institutes of 1R01NS067469-01A1; NY State Attorney General’s Office/no grant number
Research Support, Academic Entities:
  • NONE
Research Support, Foundations and Societies:
  • NONE
Stock/Stock Options/Board of Directors Compensation:
  • NONE
License Fee Payments, Technology or Inventions:
  • NONE
Royalty Payments, Technology or Inventions:
  • NONE
Stock/Stock Options, Research Sponsor:
  • NONE
Stock/Stock Options, Medical Equipment & Materials:
  • NONE
Legal Proceedings:
  • NONE
E. Molho,
Scientific Advisory Boards:
  • Allergan - consulting fee 2009,2010 Ipsen - consulting fee 2009 Merz - consulting fee 2009,2010,201 Lundbeck - consulting fee 2010
Gifts:
  • NONE
Funding for Travel or Speaker Honoraria:
  • NONE
Editorial Boards:
  • NONE
Patents:
  • NONE
Publishing Royalties:
  • NONE
Employment, Commercial Entity:
  • NONE
Consultancies:
  • NONE
Speakers’ Bureaus:
  • NONE
Other Activities:
  • NONE
Clinical Procedures or Imaging Studies:
  • NONE
Research Support, Commercial Entities:
  • Impax - site investigator, 2010,2011 Huntington Study Group - site investigator, 2009, 2010 Allergan - site investigator, 2010,2011 Parkinson Study Group/NIH - site investigator 2010,2011 Parkinson Study Group/ Molecular Biometrics - site investigator 2010 Serono - site investigator, 2011
Research Support, Government Entities:
  • NONE
Research Support, Academic Entities:
  • NONE
Research Support, Foundations and Societies:
  • NONE
Stock/Stock Options/Board of Directors Compensation:
  • NONE
License Fee Payments, Technology or Inventions:
  • NONE
Royalty Payments, Technology or Inventions:
  • NONE
Stock/Stock Options, Research Sponsor:
  • NONE
Stock/Stock Options, Medical Equipment & Materials:
  • NONE
Legal Proceedings:
  • NONE
S. Factor,
Scientific Advisory Boards:
  • NONE
Gifts:
  • NONE
Funding for Travel or Speaker Honoraria:
  • NONE
Editorial Boards:
  • Current treatment options in Neurology, Section editor 2006-2011 Clinical neurology and Neuroscience Section editor 2011
Patents:
  • NONE
Publishing Royalties:
  • Parkinson’s Disease Diagnosis and Clinical management, Demos, 2008; Drug Induced Movement Disorders, Blackwell Futura, 2005
Employment, Commercial Entity:
  • NONE
Consultancies:
  • NONE
Speakers’ Bureaus:
  • NONE
Other Activities:
  • Research grants From TEVA Neurosciences, Ipsen, UCB, Schering Plough and Ceregene
Clinical Procedures or Imaging Studies:
  • NONE
Research Support, Commercial Entities:
  • NONE
Research Support, Government Entities:
  • NONE
Research Support, Academic Entities:
  • NONE
Research Support, Foundations and Societies:
  • NONE
Stock/Stock Options/Board of Directors Compensation:
  • NONE
License Fee Payments, Technology or Inventions:
  • NONE
Royalty Payments, Technology or Inventions:
  • NONE
Stock/Stock Options, Research Sponsor:
  • NONE
Stock/Stock Options, Medical Equipment & Materials:
  • NONE
Legal Proceedings:
  • Boehringer Ingelheim Expert witness
R. Ottman, PhD,
Scientific Advisory Boards:
  • NONE
Gifts:
  • NONE
Funding for Travel or Speaker Honoraria:
  • International League Against Epilepsy, travel; Ortho-McNeil Janssen Scientific Affairs, LLC, travel; Fallon Medica, LLC, travel and speaker honorarium; EDJ Associates, travel; Tel Aviv University, travel; Coriell Institute for Medical Research, travel
Editorial Boards:
  • NONE
Patents:
  • NONE
Publishing Royalties:
  • NONE
Employment, Commercial Entity:
  • Columbia University, professor; New York State Psychiatric Institute, Research Scientist
Consultancies:
  • Ortho-McNeil Janssen Scientific Affairs, LLC. Trigeminal Solutions, Inc.
Speakers’ Bureaus:
  • NONE
Other Activities:
  • NONE
Clinical Procedures or Imaging Studies:
  • NONE
Research Support, Commercial Entities:
  • NONE
Research Support, Government Entities:
  • NIH grants: R01 NS043472, PI, 2002-2010 R01 NS036319, PI, 2002-2010 R01 NS036630, Co-I, 2004-2010 R01 NS039422, Co-I, 2004-2009 R01 NS053998, Co-I, 2007-2010 RC2 NS070344, MPI, 2009-2011 R03 NS065346, PI, 2009-2011 P20 HG005535, Co-I, 2010-2013
Research Support, Academic Entities:
  • NONE
Research Support, Foundations and Societies:
  • NONE
Stock/Stock Options/Board of Directors Compensation:
  • Trigeminal Solutions, Inc.
License Fee Payments, Technology or Inventions:
  • NONE
Royalty Payments, Technology or Inventions:
  • NONE
Stock/Stock Options, Research Sponsor:
  • NONE
Stock/Stock Options, Medical Equipment & Materials:
  • Trigeminal Solutions, Inc., member of Scientific Advisory Board, 2008-2009
Legal Proceedings:
  • NONE
L.N. Clark, PhD,
Scientific Advisory Boards:
  • NONE
Gifts:
  • NONE
Funding for Travel or Speaker Honoraria:
  • NONE
Editorial Boards:
  • NONE
Patents:
  • NONE
Publishing Royalties:
  • NONE
Employment, Commercial Entity:
  • NONE
Consultancies:
  • NONE
Speakers’ Bureaus:
  • NONE
Other Activities:
  • NONE
Clinical Procedures or Imaging Studies:
  • NONE
Research Support, Commercial Entities:
  • NONE
Research Support, Government Entities:
  • OTHER SUPPORT CLARK, L. ACTIVE: R01 NS060113 (Clark)09/29/08-08/30/123.24 calendar months NIH/NINDS$218,750 Molecular Genetic Analysis of Lysosomal Storage Disorder Genes in Parkinson Disease Goals: Analysis of lysosomal genes in the same biochemical pathway as GBA and their role in causing Parkinson’s disease Role: Principal Investigator 2P50NS038370-11(Burke)09/30/00-7/31/140.60 calendar months NIH$54,929 (Core C) Mechanism of Dopamine Neuron Degeneration The goal of this project is to use new knowledge about the mechanisms of neurodegeneration to develop therapies that will block progression. Role: Co-investigator 5RC2NS070276 (Isacson)9/30/2009-8/31/20110.42 calendar NIH$124,118 (subcontract) PD iPS Cell Line Research Consortium (Core B) This core will phenotype 30 PD cases with specific PD genetic mutations and 15 age matched controls. Skin biopsies will be transformed to iPS lines. Role: Co-investigator National Institute on Aging. 2010-20151.8 Cal mo NIH$625,000 Alzheimer Disease Research Center at Columbia University (Shelanski) Project 3 (Clark, PI ) “Glucocerebrosidase Mutations and Dementia with Lewy Bodies” In this proposed longitudinal and cross sectional study we hypothesize that GBA mutation carriers will develop the clinical manifestations of DLB and will be found to have neuropathological diagnosis of DLB more often than similarly aged non-carriers of GBA mutations. Our goal is thus to show that GBA mutations are associated with the clinical and neuropathological diagnosis of DLB. Role: Principal Investigator P50 (Silverman/Schupf)2010-20150.6 calendar months Genetics of Down’s Syndrome NIH$1,034,982 Project IV. Genetic epidemiology of Alzheimer’s disease in Down syndrome. Role: Co-Investigator R21 NS050487 (Clark)07/01/05-06/30/07 NIH/NINDS “Glucocerebrosidase mutations and Parkinson’s disease in the Ashkenazim” Goals: The objectives of this proposal are to identify disease SNPs, haplotypes and/or founder mutation(s) in the glucocerebrosidase (GBA) gene that are associated with PD in the AJ population and to explore phenotypic differences between PD cases with and without GBA mutations. Role: Principal Investigator RO1 NS36630 (Marder)07/01/04-04/30/10 NIH / NINDS Genetic Epidemiology of Parkinson’s Disease Goals: To define the range of phenotypic manifestations of parkin mutations, specifically with respect to motor vs. non-motor manifestations in families of PD cases. To estimate age specific penetrance of parkin mutations in the families of 100 parkin-positive cases ascertained by age at onset, and evaluate differences in age specific penetrance across subgroups defined by allelic state. Role: Co-investigator
Research Support, Academic Entities:
  • NONE
Research Support, Foundations and Societies:
  • N/A (Fahn/Clark) 06/30/10-7/01/112.80 calendar months Parkinson’s Disease Foundation$90,445 Provides funding for genetic analysis of Parkinson’s Disease and Essential Tremor including candidate gene analysis and gene discovery N/A (Marder/Bressman/Giladi)06/01/09-05/31/121.00 calendar months Michael J. Fox Foundation$324,641 Parkinson’s Disease, Ashkenazi Jews and LRRK2: A Consortium This is a 3 site consortium designed to determine the phenotypic characteristics of LRRK2 carriers, the penetrance of LRRK2 in Ashkenazi, and genetic modifiers of LRRK2 including expression data. Role: Co-investigator IIRG (Schupf)08/01/08-7/31/110.72 calendar months Alzheimer’s Association$90,907 Genetics of Estrogen and Alzheimer Disease in a multiethnic cohort. To determine whether SNPs in five candidate genes, ER-beta, CYP17, CYP19, and HSD17B1, are associated with increased risk for AD and related phenotypes. Role: Co-Investigator
Stock/Stock Options/Board of Directors Compensation:
  • NONE
License Fee Payments, Technology or Inventions:
  • NONE
Royalty Payments, Technology or Inventions:
  • NONE
Stock/Stock Options, Research Sponsor:
  • NONE
Stock/Stock Options, Medical Equipment & Materials:
  • NONE
Legal Proceedings:
  • NONE
and K. Marder, MD, MPH
Scientific Advisory Boards:
  • NONE
Gifts:
  • NONE
Funding for Travel or Speaker Honoraria:
  • NONE
Editorial Boards:
  • Editorial board of Neurology Section editor, Current Neurology and Neuroscience
Patents:
  • NONE
Publishing Royalties:
  • NONE
Employment, Commercial Entity:
  • NONE
Consultancies:
  • NONE
Speakers’ Bureaus:
  • NONE
Other Activities:
  • NONE
Clinical Procedures or Imaging Studies:
  • NONE
Research Support, Commercial Entities:
  • Research support through Columbia University from Amarin Neuroscience LTD, Boehringer-Ingelheim and Neurosearch. NeuroSearch Sweden AB;
Research Support, Government Entities:
  • NS36630 (PI), 1UL1 RR024156-01(Director PCIR), PO412196- G (co-investigator), PO412196-G (co-investigator),
Research Support, Academic Entities:
  • NONE
Research Support, Foundations and Societies:
  • Parkinson Disease Foundation (investigator), Huntington’s Disease Society of America (investigator), Parkinson Study Group (Co-chair, executive committee) Michael J Fox foundation
Stock/Stock Options/Board of Directors Compensation:
  • NONE
License Fee Payments, Technology or Inventions:
  • NONE
Royalty Payments, Technology or Inventions:
  • NONE
Stock/Stock Options, Research Sponsor:
  • NONE
Stock/Stock Options, Medical Equipment & Materials:
  • NONE
Legal Proceedings:
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Author affiliations and funding information are provided at the end of the article.
corresponding authorCorresponding author.
Correspondence & reprint requests to Dr. Alcalay: rna2104/at/columbia.edu
Received November 29, 2010; Accepted October 7, 2011.
Objective:
To assess the cognitive phenotype of glucocerebrosidase (GBA) mutation carriers with early-onset Parkinson disease (PD).
Methods:
We administered a neuropsychological battery and the University of Pennsylvania Smell Identification Test (UPSIT) to participants in the CORE-PD study who were tested for mutations in PARKIN, LRRK2, and GBA. Participants included 33 GBA mutation carriers and 60 noncarriers of any genetic mutation. Primary analyses were performed on 26 GBA heterozygous mutation carriers without additional mutations and 39 age- and PD duration–matched noncarriers. Five cognitive domains, psychomotor speed, attention, memory, visuospatial function, and executive function, were created from transformed z scores of individual neuropsychological tests. Clinical diagnoses (normal, mild cognitive impairment [MCI], dementia) were assigned blind to genotype based on neuropsychological performance and functional impairment as assessed by the Clinical Dementia Rating (CDR) score. The association between GBA mutation status and neuropsychological performance, CDR, and clinical diagnoses was assessed.
Results:
Demographics, UPSIT, and Unified Parkinson's Disease Rating Scale–III performance did not differ between GBA carriers and noncarriers. GBA mutation carriers performed more poorly than noncarriers on the Mini-Mental State Examination (p = 0.035), and on the memory (p = 0.017) and visuospatial (p = 0.028) domains. The most prominent differences were observed in nonverbal memory performance (p < 0.001). Carriers were more likely to receive scores of 0.5 or higher on the CDR (p < 0.001), and a clinical diagnosis of either MCI or dementia (p = 0.004).
Conclusion:
GBA mutation status may be an independent risk factor for cognitive impairment in patients with PD.
Cognitive impairment is one of the most disabling nonmotor complications of Parkinson disease (PD). Older age, longer disease duration, and severity of extrapyramidal signs are the most important risk factors for cognitive impairment in the setting of PD.14 Recently, mutations in the glucocerebrosidase (GBA) gene were identified as risk factors for PD,5 affecting up to 6% of all early-onset PD cases in the United States.6 Two independent autopsy studies found that GBA mutations were associated with cortical Lewy bodies, suggesting that Lewy body development may be more extensive in GBA carriers, and might be associated with cognitive impairment.7,8 Among 699 participants in the Consortium on Risk for Early Onset Parkinson's Disease (CORE-PD)9 with age at onset (AAO) <51 years, carriers of GBA mutations (N370S or L444P, n = 37) self-reported cognitive impairment more frequently than noncarriers. While data from the Mini-Mental State Examination (MMSE)10 did not confirm this difference,9 in another study, GBA mutation carriers performed worse than noncarriers on the Montreal Cognitive Assessment (MoCA).11 In addition, a mouse model of Gaucher disease was shown to exhibit memory deficits as well as progressive accumulation of α-synuclein/ubiquitin aggregates in hippocampal neurons.12
In the current study, our primary goal was to examine the neuropsychological profile of GBA carriers compared to noncarriers. To further characterize the GBA phenotype, we assessed extrapyramidal features, olfaction, and depression.
Participants.
A total of 147 individuals with early-onset PD (33 GBA carriers and 114 noncarriers) who participated in Part II of the CORE-PD study were included. Details of the CORE-PD study have been described.13 In brief, patients with PD, diagnosed by movement disorders specialists, were recruited for Part I of CORE-PD from 16 sites based on AAO of PD <51 years and a score on the MMSE >23. (The inclusion of individuals with MMSE >23 was incorporated to ensure that a reliable history could be obtained from each subject. There was no MMSE exclusion criterion for the follow-up, Part II examination.) A blood sample for DNA was sent to the NINDS Human Genetics Resource Center DNA and Cell Line Repository (http://ccr.coriell.org). Participants were screened for mutations in SNCA, PARKIN, PINK-1, DJ-1, LRRK2, and GBA (N370S and L444P mutations).6 Given the higher frequency of GBA mutations among Ashkenazi Jews, participants who self-reported Ashkenazi Jewish ancestry were further screened for an additional 6 common GBA mutations (V394L, D409G, A456P, R496H, 84GG, and exon 2 IVS2 + 1) by direct sequencing. A total of 147 participants completed the Part II evaluation. The present analysis was restricted to 33 carriers of GBA mutations and 60 individuals who did not have any mutations in the other genes tested.14 The GBA mutation carriers (n = 33) included 7 heterozygous L444P carriers, 16 heterozygous N370S carriers, 1 N370S homozygote, 2 84GG carriers, and 1 R496H carrier. Six individuals were heterozygous for GBA mutations and carried mutations in other PD-related genes (3 with both GBA and PARKIN mutations, 3 with both GBA and LRRK2 G2019S mutations). The analyses presented here focused on the 26 heterozygous GBA mutation carriers who did not have PARKIN or LRRK2 mutations. We also conducted sensitivity analyses including all 33 GBA carriers.
To ensure that the noncarriers were frequency matched to the GBA carriers in age and PD duration at the time of the examination, we included only noncarriers who were 47 years or older with PD duration between 7 and 25 years, similar to GBA carriers. This resulted in the exclusion of 21 noncarriers. The final number of included participants was 72 (33 GBA carriers, 39 noncarriers).
Clinical evaluation.
Clinical evaluation in Part II of CORE-PD included a neurologic examination performed by a research physician, a videotaped assessment of the Unified Parkinson's Disease Rating Scale (UPDRS) evaluated by a movement disorders specialist (E.D.L.), a neuropsychological battery, and a psychiatric evaluation including the Beck Depression Inventory–II (BDI-II).15 The University of Pennsylvania Smell Identification Test (UPSIT, Sensonics, Inc., Haddonfield, NJ)16 was added in 2008 and was available for 31 participants. A Clinical Dementia Rating (CDR)17 score was assigned to each participant by a research physician (L.R.) who administered the neurologic and neuropsychological testing. A consensus panel, including the research physician (L.R.), a neurologist (K.M.), and a neuropsychologist (E.C.), assigned a clinical consensus diagnosis to each participant based on medical history, neurologic examination, neuropsychological performance, and functional impairment. Dementia diagnosis required impairment on neuropsychological evaluation in at least 2 of the following domains: memory, language, executive function, and visuospatial processing, as well as functional impairment as reflected by a CDR score greater than 0. Mild cognitive impairment (MCI) was diagnosed using Petersen's criteria, i.e., impairment in at least 1 neuropsychological domain or low scores in more than 1 domain, with no significant functional impairment.18 None of the researchers was aware of the participants' mutation status at the time of the evaluation or consensus diagnosis.
Standard protocol approvals, registrations, and patient consents.
Institutional review boards at all participating sites approved the protocols and consent procedures. Written informed consent was obtained from all participants in the study.
Neuropsychological evaluation.
Details of the neuropsychological battery have been previously described14 and are summarized in table e-1 on the Neurology® Web site at www.neurology.org. The battery was designed so that it was time-limited (i.e., with an administration time of approximately 30–45 minutes), could be administered in participants' homes, could be administered in English and Spanish, and could be successfully completed by patients with motor impairment. A second MMSE was performed on all participants at the time of the neuropsychological battery but was not included in the domain scores. Five cognitive domains were created based on previous research assessing predictors of cognitive decline in PD (table e-1).14,1920
In a separate analysis, we further reclassified the battery into 3 domains (table e-2): executive function (including executive function, processing speed, and attention), memory (including memory tests as in table e-1 and California Verbal Learning Test-II recognition errors), and visuospatial domain (unchanged).
Statistical analysis.
Demographic data, disease characteristics, MMSE, neuropsychological test performance, and UPSIT performance of GBA carriers and noncarriers were compared using χ2, Fisher exact, and Student t tests, as appropriate. Individual neuropsychological test scores for all participants were transformed to create Z scores using means and standard deviations of all participants. Composite scores for each domain were computed by averaging the mean Z scores from the individual tests comprising each domain (see table e-1). Performance on neuropsychological testing was compared between GBA mutation carriers and noncarriers on individual tests and cognitive domains.
CDR scores were categorized as 0 (normal), 0.5, or 1 or higher (dementia) and compared between GBA carriers and noncarriers. The association between clinical diagnosis of cognitive impairment (which was made by consensus meeting based on neuropsychological performance and CDR), either MCI or dementia (dependent variable), and GBA mutation status (independent variable) was assessed in logistic regression models. The association was first assessed in a univariate model, and then in a multivariate model, adjusting for age in years, AAO of PD, gender, UPDRS-III score, motor phenotype (tremor dominant vs postural instability gait difficulty),21 and years of education.
Finally, sensitivity analyses were performed. We repeated the analyses, including all GBA mutation carriers (n = 33), and all noncarriers (n = 60), including those (n = 21) who were excluded for age and disease duration frequency matching.
Demographic and disease characteristics of carriers and noncarriers of GBA mutations are presented in table 1. Age (frequency matched), gender, education, AAO, and BDI-II scores did not differ between carriers and noncarriers. UPSIT performance was in the severe microsmia range (score of 25 or less out of 40)16 for 29 of 31 participants with available UPSIT data (table 1). UPSIT performance was not associated with GBA mutation status, neuropsychological performance, or clinical diagnosis of cognitive impairment. Raw scores on individual neuropsychological tests are reported in table 2. Three GBA carriers and 1 noncarrier (whose initial MMSE screen was >23) were too cognitively impaired during the Part II evaluation to complete the full neuropsychological evaluation and therefore domain scores could not be computed. When carriers' performance was compared to noncarriers', carriers scored significantly lower on nonverbal memory tests (Visual Reproduction I, Visual Reproduction II, Benton Visual Retention Test–Recognition; table 2).
Table 1
Table 1
Demographic and disease characteristics of GBA carriers and noncarriers
Table 2
Table 2
Performance of GBA mutation carriers and noncarriers on neuropsychological testing
MMSE scores, cognitive domain scores, CDR scores, and the clinical consensus diagnoses of cognitive impairment are reported in table 3. GBA carriers' MMSE performance was significantly lower than that of noncarriers. Mean scores in all 5 cognitive domains were lower in the GBA carrier group, reaching significance for the memory (p = 0.017) and visuospatial (p = 0.028) domains. These findings were unchanged when the neuropsychological battery was reclassified into 3 domains (memory, p = 0.015; executive function, p = 0.394; visuospatial, p = 0.028). GBA carriers were more likely to receive higher CDR scores than noncarriers (p < 0.001).
Table 3
Table 3
Cognitive performance of GBA carriers and noncarriers
Among participants who received a consensus clinical diagnosis of dementia (11 GBA carriers, 6 noncarriers), GBA mutation carriers did not present a distinctive pattern of impairment in specific cognitive domains. All participants with dementia had both memory and executive impairment. GBA mutation carriers were more likely to receive a clinical consensus diagnosis of MCI or dementia than noncarriers (p = 0.004, table 3). In a univariate logistic model, GBA mutation status was associated with clinical diagnosis of cognitive impairment (either MCI or dementia combined) (odds ratio [OR] = 5.8, 95% confidence interval [CI] 1.7–19.9, p = 0.005). The association persisted when adjusted for age, gender, disease duration, UPDRS-III, motor phenotype, and education (OR = 6.2, 95% CI 1.3–29.0, p = 0.021).
Sensitivity analyses including all GBA carriers (n = 33) and all noncarriers (n = 60) revealed that GBA carriers were more impaired on memory (p = 0.046) and attention (p = 0.007) domains compared to noncarriers, using the 5-domain model. In this larger sample, significant differences between GBA carriers vs noncarriers in CDR scores (p < 0.001) and in the association between GBA mutation status and cognitive impairment (p = 0.001) were similar to those obtained in the primary analyses.
While longitudinal follow-up of patients with PD suggests that cognitive impairment occurs in 83% of patients with PD followed up to 20 years,22 studies have shown marked heterogeneity in the profile of cognitive impairment and in the time from onset of motor symptoms to the development of cognitive impairment.2325Previous studies have shown that genetic risk factors, including variations in microtubule-associated protein tau (MAPT),26 α-synuclein (SNCA),26 and catechol-O-methyl-transferase (COMT)27,28may explain some of the heterogeneity in cognitive performance in PD. We and others have shown that GBA mutations are associated with cortical Lewy body pathology. GBA mutation status was also previously associated with dementia using DSM-IV criteria, after adjusting for covariates, including APOE4 status and Alzheimer disease pathology.7 Our findings of olfactory and cognitive impairment, most notably in nonverbal memory tasks, are all consistent with diffuse cortical neuropathology. The association between GBA mutation status and other nonmotor signs and symptoms of PD (e.g., REM sleep behavior disorder or hallucinations) remains to be investigated.
We may have underestimated differences in cognitive performance. Our study was probably biased toward the null: first, we compared GBA carriers to other affected individuals who by themselves exhibit cognitive impairment (table 2). Second, we included only participants with MMSE >23 on initial evaluation. We cannot conclude whether GBA mutation status is associated with PD dementia only or with dementia with Lewy body as well. Finally, because only selected mutations were genotyped, rather than complete sequencing, we may have inadvertently misclassified other GBA mutation carriers as noncarriers.
While GBA mutation status may explain a portion of the variability in cognitive performance, not all GBA carriers demonstrate cognitive impairment. For example, one of the GBA mutation carriers whose performance on neuropsychological testing was within normal range (table 3) had a motor disease duration of 21 years. Further research is required to understand additional modifiers of cognitive performance, some of which may be protective. Our study was not powered to assess for interactions with MAPT, SNCA, or COMT variants, or to assess for a “dose” effect. It included only a single carrier of 2 GBA mutations, who was excluded from all but the sensitivity analyses. It also was not powered to compare carriers of different GBA mutations, e.g., N370S and R496H vs L444P and 84GG. A previous study has reported that carriers of “severe” GBA mutations (including L444P) may have a higher risk for PD than carriers of “milder” mutations (e.g., N370); however, cognitive impairment was not assessed.29 The neuropsychological battery, which was limited in scope, may have lacked tests that would have identified more specific executive deficits (e.g., Wisconsin Card Sorting Test). Finally, the study design, which includes a single complete neuropsychological evaluation that did not allow us to assess rate of progression, also represents a limitation.
Further research is required to assess whether nonverbal memory may be used as an early marker of cognitive impairment in mutation carriers. GBA mutation carriers may serve as an enriched sample to assess for early cognitive outcomes. Prospective longitudinal studies which include GBA mutation carriers with and without PD will help assess the time and rate of development of cognitive impairment in carriers.
Supplementary Material
Data Supplement
Accompanying Editorial
ACKNOWLEDGMENT
The authors thank Dr. Paul Greene and Linda Winfield for participant referral.
GLOSSARY
AAOage at onset
BDI-IIBeck Depression Inventory–II
CDRClinical Dementia Rating
CIconfidence interval
CORE-PDConsortium on Risk for Early Onset Parkinson's Disease
DSM-IVDiagnostic and Statistical Manual of Mental Disorders, 4th edition
MCImild cognitive impairment
MMSEMini-Mental State Examination
MoCAMontreal Cognitive Assessment
ORodds ratio
PDParkinson disease
UPDRSUnified Parkinson's Disease Rating Scale
UPSITUniversity of Pennsylvania Smell Identification Test

Footnotes
Editorial, page 1372
Supplemental data at www.neurology.org
AUTHOR AFFILIATIONS
From the Department of Neurology (R.N.A., E.C., H.M.-S., M.-X.T., L.R., M.O.R., D.R., E.L., S. Fahn, C.W., L.C., S. Frucht, B.F., R.O., K.M.), Taub Institute for Research on Alzheimer's Disease and the Aging Brain (R.N.A., M.-X.T., B.R., M.V., S.K., E.L., L.N.C., K.M.), Gertrude H. Sergievsky Center (E.L., L.C., R.O., K.M.), Department of Pathology and Cell Biology (L.N.C.), and Center for Human Genetics (L.N.C.), College of Physicians and Surgeons, Department of Epidemiology, Mailman School of Public Health (E.L., R.O.), and Department of Psychiatry (K.M.), Columbia University, New York, NY; Department of Neurological Sciences (C.C.), Rush University Medical Center, Chicago, IL; Parkinson's Disease and Movement Disorders Center (A.C., A.S.), Pennsylvania Hospital, Philadelphia; The Institute for Neurodegenerative Disorders (D.J.), New Haven, CT; Struthers Parkinson's Center (M.N.), Park Nicollet Clinic, Golden Valley, MN; The Alan and Barbara Mirken Department of Neurology (S.B.), Beth Israel Medical Center, New York, NY; Department of Neurology (S.B.), Albert Einstein College of Medicine, Bronx, NY; Dr. John T. MacDonald Foundation (W.K.S.), Department of Human Genetics, Miami Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL; Parkinson's Institute (C.T.), Sunnyvale, CA; Marshfield Clinic (S.M.), Department of Neurology, Marshfield, WI; Data Coordinating Center (H.A.) and Division of Epidemiology (R.O.), New York State Psychiatric Institute, New York; Central DuPage Hospital (M.R.), Neurosciences Institute, Movement Disorders Center, Winfield, IL; Department of Neurology (K.N.), NorthShore University Health System, Evanston, IL; Department of Neurology (K.N.), University of Chicago, Pritzker School of Medicine, Chicago, IL; Butler Hospital (J.H.F.), Providence, RI; Department of Neurology (J.H.F.), Alpert Medical School of Brown University, Providence, RI; Department of Neurology (R.P.), College of Medicine, University of Tennessee Health Science Center, Memphis; Morris K. Udall Parkinson's Disease Research Center of Excellence (L.M.), Department of Psychiatry and Behavioral Sciences (L.M.), and Department of Neurology and Neurological Sciences (L.M.), Johns Hopkins University School of Medicine, Baltimore, MD; Medical College of Wisconsin (B.H.), Milwaukee; New York State Department of Health Wadsworth Center (H.P.), Albany, NY; Parkinson's Disease and Movement Disorders Center (E.M.), Albany Medical Center, Albany, NY; and Department of Neurology (S.F.), Emory University, Atlanta, GA.
AUTHOR CONTRIBUTIONS
Dr. Alcalay: drafting/revising the manuscript, study concept or design, analysis or interpretation of data, statistical analysis, obtaining funding. Dr. Caccappolo: drafting/revising the manuscript, study concept or design, analysis or interpretation of data, statistical analysis. H. Mejia-Santana: study concept or design, study supervision. Dr. Tang: analysis or interpretation of data, statistical analysis. Dr. Rosado: study concept or design, analysis or interpretation of data, acquisition of data, study supervision. Dr. Reilly: drafting/revising the manuscript, study concept or design, acquisition of data. D. Ruiz: study concept or design, acquisition of data. B. Ross: analysis or interpretation of data, acquisition of data. Dr. Verbitsky: analysis or interpretation of data, acquisition of data. S. Kisselev: analysis or interpretation of data, acquisition of data. Dr. Louis: drafting/revising the manuscript, acquisition of data. Dr. Comella: drafting/revising the manuscript, acquisition of data, study supervision. Dr. Colcher: drafting/revising the manuscript, acquisition of data. Dr. Jennings: drafting/revising the manuscript, acquisition of data. Dr. Nance: drafting/revising the manuscript, analysis or interpretation of data, acquisition of data. Dr. Bressman: drafting/revising the manuscript, acquisition of data. Dr. Scott: drafting/revising the manuscript, analysis or interpretation of data, acquisition of data, study supervision. Dr. Tanner: drafting/revising the manuscript, acquisition of data. Dr. Mickel: drafting/revising the manuscript, acquisition of data. Dr. Andrews: analysis or interpretation of data, acquisition of data, study supervision. Dr. Waters: drafting/revising the manuscript, acquisition of data. Dr. Fahn: drafting/revising the manuscript, study concept or design, acquisition of data. Dr. Cote: drafting/revising the manuscript, acquisition of data. Dr. Frucht: analysis or interpretation of data, acquisition of data. Dr. Ford: drafting/revising the manuscript, acquisition of data. Dr. Rezak: drafting/revising the manuscript, acquisition of data. Dr. Novak: drafting/revising the manuscript, acquisition of data, study supervision. Dr. Friedman: drafting/revising the manuscript, acquisition of data. Dr. Pfeiffer: drafting/revising the manuscript, acquisition of data. Dr. Marsh: drafting/revising the manuscript, acquisition of data. Dr. Hiner: drafting/revising the manuscript, study concept or design, acquisition of data, study supervision. Dr. Siderowf: drafting/revising the manuscript, acquisition of data. Dr. Payami: drafting/revising the manuscript, acquisition of data. Dr. Molho: drafting/revising the manuscript, analysis or interpretation of data, acquisition of data. Dr. Factor: drafting/revising the manuscript, acquisition of data. Dr. Ottman: drafting/revising the manuscript, study concept or design, analysis or interpretation of data. Dr. Clark: drafting/revising the manuscript, study concept or design, analysis or interpretation of data, acquisition of data, study supervision, obtaining funding. Dr. Marder: drafting/revising the manuscript, study concept or design, analysis or interpretation of data, acquisition of data, obtaining funding.
STUDY FUNDING
This study was funded by NIH NS036630, UL1 RR024156 (K.S.M.), NS050487, NS060113 (L.N.C.), the Parkinson's Disease Foundation (K.S.M., S.F., and L.N.C.), P50 NS039764 (W.K.S.), and NS36960 (H.P.). R.N.A. is a Brookdale Foundation Leadership in Aging Fellow.
DISCLOSURE
Dr. Alcalay receives research support from the NIH (K12 part of UL1 RR024156) and the Brookdale Leadership in Aging Fellowship and received research support from the Michael J. Fox Foundation. Dr. Caccappolo, H. Mejia-Santana, Dr. Tang, Dr. Rosado, Dr. Reilly, D. Ruiz, B. Ross, Dr. Verbitsky, and S. Kisselev report no disclosures. Dr. Louis receives research support from the NIH [NINDS #R01 NS42859 (principal investigator), NINDS #R01 NS39422 (principal investigator), NINDS #R56 NS042859 (principal investigator), NINDS #T32 NS07153-24 (principal investigator), NIA #2P01 AG0027232-16 (principal investigator), and NINDS #R01 NS36630 (coinvestigator)] and the Parkinson's Disease Foundation (principal investigator). Dr. Comella reports no disclosures. Dr. Colcher is on a speaker's bureau for Lundbeck Pharmaceuticals and Teva Pharmaceuticals and has received honoraria from Plan 365, Advanced Health Media, and Healthlogix and Robert Wood Johnson for speaking engagements in 2009. Dr. Jennings reports no disclosures. Dr. Nance has received research funding from Medivation, Santhera, Neurosearch, Juvantia, Schwarcz, Pfizer, Neuraltus, Impax, CHDI, NINDS 5 U10 NS044466-05 (site investigator), NINDS 5 RO1 NS36630 (site investigator), NINDS NS640068-08 (site investigator, Steering Committee), NHGRI/NINDS 501 HG 02449-07 (site investigator), NINDS 1RO1 NS052592-01 (site investigator), NCCAM (site investigator), and 1 RO1 NS060118-01A1 (site investigator); support for Centers of Excellence from National Parkinson Foundation and Huntington Disease Society of America; speaking honoraria from American Academy of Neurology, Huntington Disease Society of America, and Augsburg College; and royalties from Oxford University Press (Juvenile Huntington's Disease, published 2009); and her spouse has served on speaker's bureaus for Genentech and Schering-Plough. Dr. Bressman reports no disclosures. Dr. Scott is a coinventor on patent regarding use of genetic data for assessing risk of developing age-related macular degeneration, licensed to ArcticDx. Dr. Tanner serves on the advisory board of the Michael J. Fox Foundation Scientific Advisory Board and the National Spasmodic Dystonia Association Scientific Advisory Board; has consulted for Impax Pharmaceuticals, Lundbeck Pharmaceuticals, Pacific Health Research Institute (consultant on NIH & Department of Defense funded research), Stanford University (consultant on Muscular Dystrophy Association funded research), and SunHealth Research Institute (consultant on MJFF founded research); and has received research support from the Michael J. Fox Foundation, Brin Foundation, James and Sharron Clark, National Institutes of Health (NIH), Parkinson's Institute and Clinical Center, Parkinson's Disease Foundation, Department of Defense, and Welding Products Manufacturer's Group. Dr. Mickel and Dr. Andrews report no disclosures. Dr. Waters received speaking honorarium from Boehringer and Teva. Dr. Fahn reports receiving support from consulting and advisory board membership with honoraria from Oxford Biomedica (September 2009), Proctor-Goodwin (November 2009), GE Healthcare (November 2009), RJG Foundation (March 2010), IMPAX Pharmaceuticals (May 2010), and Lundbeck (June 2010); he is receiving research support from the Parkinson's Disease Foundation (no salary support); he received a grant from the Smart Family Foundation (no salary support); and received a grant from the US Department of Defense's Telemedicine and Advanced Technology Research Center (TATRC) for the World Parkinson Congress 2010, and a grant from the National Institutes of Health for the World Parkinson Congress 2010. Dr. Fahn received lecture honoraria from Columbia University (July 2009), Sun Pharmaceuticals India (September 2009), World Association of Sleep Medicine (November 2009), American Academy of Neurology (April 2010), and Columbia University (July 2010). Dr. Fahn reports serving as an editor with author honoraria from “Current Neurology and Neurosurgery Report” (annual); and Elsevier for co-author of book Principles and Practice of Movement Disorders. Dr. Cote reports no disclosures. Dr. Frucht has received consultation fees from Lundbeck, Jazz Pharmaceuticals, and Merz. Dr. Ford serves on the physician advisory board for Medtronic, Inc. Dr. Rezak is on the speaker bureau of Teva, Medtronic, Novartis, Boehringer Ingelheim, and Galxo. Dr. Novak reports no disclosures. Dr. Friedman has received speaking honorarium from Teva, Boehringer-Ingelheim, and GlaxoSmithKline; received research support from Epivax, Teva, Cephalon, EMD Serono, Acadia, the Michael J. Fox Foundation, and the National Institute of Health; has received consultation fee from Teva, EMD Serono, Acadia, United Biosource, and Clintara; and has received book royalties from Demos Press. Dr. Pfeiffer has received royalties for book editing from CRC Press (Taylor & Francis) and Humana Press; has received speaking honorarium from Boehringer-Ingelheim, Novartis, and Teva; has received consultation honoraria from Solvay, Theravance, Genactis, and Schlesinger Associates; has research support from Novartis, Boehringer-Ingelheim, UCB/Schwarz, and Santhera; received legal consulting fees from Spriggs & Hollingsworth, Davis Graham & Stubbs, and Tucker Ellis & West; and is the journal editor of Parkinsonism and Related Disorders (Elsevier). Dr. Marsh served on the advisory board of the National Parkinson Foundation and the American Parkinson's Disease Association; has received consultation fee from Acadia Pharmaceutical, Ovation Pharmaceutical, Merck Serono, and Boehringer Ingelheim; has received research support from the National Institutes of Health, Forest Research Institute, Eli Lilly, Michael J. Fox Foundation for Parkinson's Research, and the National Parkinson Foundation; and has received book royalties from Taylor and Francis/Informa. Dr. Hiner has received speaking honorarium from Teva Neuroscience. Dr. Siderowf is supported by a Morris K. Udall Parkinson's Disease Research Center of Excellence grant from NINDS (NS-053488), and has been supported by SAP4100027296, a health research grant awarded by the Department of Health of the Commonwealth of Pennsylvania from the Tobacco Master Settlement Agreement under Act 2001-77; has received consulting fees from Teva Neuroscience, Supernus Pharmaceuticals, Schering-Plough, and Merck Serono; and has received speaking honorarium from Teva Neuroscience. Dr. Payami has received funding from the NIH (NS36960). Dr. Molho is supported by the Riley Family Chair in Parkinson's Disease. Dr. Factor reports no disclosures. Dr. Ottman serves on the scientific advisory board for and holds stock options in Trigeminal Solutions, Inc; has received funding for travel from the International League Against Epilepsy, the National Institute for Mental Health, and Coriell Institute for Medical Research; has received speaker honoraria for non-industry sponsored lectures; serves as a consultant to Ortho-McNeil Janssen Scientific Affairs, LLC.; and received research support from the NIH through #R01 NS043472 [PI], #R01 NS036319 [PI], #R01 NS036630 [Co-I], #R03 NS065346 [PI], #RC2 NS070344 [MPI], #R01 NS039422 [Co-I], and #R01 NS053998 [Co-I]. Dr. Clark reports no disclosures. Dr. Marder served on the editorial board of Neurology®; received research support from Amarin Corporation, and NeuroSearch Sweden AB; and receives research support from the NIH [#NS36630 (PI), 1UL1 RR024156-01 (Director PCIR), PO412196-G (Co-I), and PO412196-G (Co-I)], and from the Parkinson Disease Foundation, Huntington's Disease Society of America, and the Parkinson Study Group, and the Michael J. Fox Foundation. Go to Neurology.org for full disclosures.
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