1,2 Tetsuro Fujii,1 Yusuke Sekino,1 Hiroki Endo,1 Kunihiro Hosono,1 Takashi Nonaka,1 Tomoko Koide,1 Hirokazu Takahashi,1 Masato Yoneda,1 Ayumu Goto,1 Yasunobu Abe,1 Noritoshi Kobayashi,1 Hiroyuki Kirikoshi,1 Kensuke Kubota,1 Satoru Saito,1 Eiji Gotoh,3 Shin Maeda,1 and Atsushi Nakajima1Background
The ideal medication for acid-related diseases should have a rapid onset of action to promote hemostasis and cause efficient resolution of symptoms. The aim of our study was to comparatively investigate the inhibitory effect on gastric acid secretion of a single oral administration of omeprazole plus mosapride with that of omeprazole alone.
Methods
Ten Helicobacter pylori-negative male subjects participated in this randomized, two-way crossover study. Intragastric pH was monitored continuously for 6 hours after a single oral administration of omeprazole 20 mg or that of omeprazole 20 mg plus mosapride 5 mg (the omeprazole being administered one hour after the mosapride). Each administration was separated by a 7-days washout period.
Results
The average pH during the 6-hour period after administration of omeprazole 20 mg plus mosapride 5 mg was higher than that after administration of omeprazole 20 mg alone (median: 3.22 versus 4.21, respectively; p = 0.0247).
Conclusions
In H. pylori -negative healthy male subjects, an oral dose of omeprazole 20 mg plus mosapride 5 mg increased the intragastric pH more rapidly than omeprazole 20 mg alone.
Keywords: Intragastric acidity, Omeprazole, Mosapride