PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of bmcsysbioBioMed Centralsearchsubmit a manuscriptregisterthis articleBMC Systems Biology
 
BMC Syst Biol. 2012; 6: 20.
Published online Mar 21, 2012. doi:  10.1186/1752-0509-6-20
PMCID: PMC3338090
Predicting new molecular targets for rhein using network pharmacology
Aihua Zhang,1,2 Hui Sun,1,2 Bo Yang,1,2 and Xijun Wangcorresponding author1,2
1National TCM Key Lab of Serum Pharmacochemistry, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin 150040, China
2Key Pharmacometabolomics Platform of Chinese Medicines, Heping Road 24, Harbin 150040, China
corresponding authorCorresponding author.
Aihua Zhang: aihua--zhang/at/163.com; Hui Sun: metabolomics/at/126.com; Bo Yang: metabonomics/at/126.com; Xijun Wang: xijunwangls/at/126.com
Received January 12, 2012; Accepted March 21, 2012.
Abstract
Background
Drugs can influence the whole biological system by targeting interaction reactions. The existence of interactions between drugs and network reactions suggests a potential way to discover targets. The in silico prediction of potential interactions between drugs and target proteins is of core importance for the identification of new drugs or novel targets for existing drugs. However, only a tiny portion of drug-targets in current datasets are validated interactions. This motivates the need for developing computational methods that predict true interaction pairs with high accuracy. Currently, network pharmacology has used in identifying potential drug targets to predicting the spread of drug activity and greatly contributed toward the analysis of biological systems on a much larger scale than ever before.
Methods
In this article, we present a computational method to predict targets for rhein by exploring drug-reaction interactions. We have implemented a computational platform that integrates pathway, protein-protein interaction, differentially expressed genome and literature mining data to result in comprehensive networks for drug-target interaction. We used Cytoscape software for prediction rhein-target interactions, to facilitate the drug discovery pipeline.
Results
Results showed that 3 differentially expressed genes confirmed by Cytoscape as the central nodes of the complicated interaction network (99 nodes, 153 edges). Of note, we further observed that the identified targets were found to encompass a variety of biological processes related to immunity, cellular apoptosis, transport, signal transduction, cell growth and proliferation and metabolism.
Conclusions
Our findings demonstrate that network pharmacology can not only speed the wide identification of drug targets but also find new applications for the existing drugs. It also implies the significant contribution of network pharmacology to predict drug targets.
Articles from BMC Systems Biology are provided here courtesy of
BioMed Central