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Logo of bmcpediBioMed Centralsearchsubmit a manuscriptregisterthis articleBMC Pediatrics
Published online 2012 January 20. doi: 10.1186/1471-2431-12-8

Table 3

Summary of guidelines on pharmacological therapy of ocular disease in the paediatric population

Ref.OrganisationTitleDiseaseQuality of evidenceTreatment (Licensing status)CountryYear
[41]National Guideline Clearinghause (NGC)Guidelines for the treatment and management of acute bacterial conjunctivitis in children and adults.Acute bacterial conjunctivitisITopical antibiotic therapy:
• Norfloxacin 0.3% (nl)
• Ciprofloxacin 0.3%
• Ofloxacin 0.3%
• Levofloxacin 0.5% (nl UK, nl USA)
• Lomefloxacin 0.3%
• Moxifloxacin 0.5% (nl UK)
• Gatifloxacin 0.3% (nl IT, nl UK)
• Chloramphenicol 0.5% (nl USA)
• Sulfacetamide Sodium 10% (nl)
• Erythromycin 0.5% (nl)
• Gentamicin Sulfate 0.3% (nl)
• Trimethoprim Sulfate/Polymyxin B 10000 U/1 mg/mL (nl IT)
• Fusidic acid 0.1% (nl IT, nl USA)
• Tobramycin 0.3% (nl UK, nl USA)
• Povidone-iodine 1.25% (nl UK, nl USA)
• Bacitracin (nl)

Ocular steroids and steroid-antibiotic:
• Prednisolone (nl IT, nl USA)
• Fluorometholone 0.1%/sulfacetamide sodium 10% (nl)
• Fluorometholone 0.1%
• Neomycin/polymyxin B/dexamethasone 0.1% (nl IT)
• Gentamicin 0.3%/prednisolone acetate 0.1% (nl)
• Tobramycin 0.3%/dexamethasone 0.1% (nl)
[34]Canadian Paediatric SocietyRecommendations for the prevention of neonatal ophthalmiaProphylaxis to prevent neonatal ophthalmia due to N gonorrhoeaeIII• Silver nitrate 1% eye drops (nl)
• Erythromycin 0.5% ointment (nl)
• Tetracycline 1% ointment (nl)
Canada2002 (Rev. 2009)
[29]Moore W. and Nischal K.K.Pharmacologic management of glaucoma in childhoodGlaucomaI• Β-Blockers: Betaxolol 0.25% (nl)
• Carbonic Anhydrase Inhibitors: Dorzolamide 2% (nl UK, nl USA)
• Prostaglandin Analogs: Latanoprost (nl), Travoprost (nl), Bimatoprost (nl)
• Adrenoceptor Agonists: Brimonidine (nl UK), Apraclonidine (nl)
• Parasympathomimetics: Pilocarpine (nl UK, nl USA)
[39]Royal College of OphthalmologistsGuidelines for the management of amblyopiaAmbliopiaIII• Refractive correction (glasses)
• Patching: from 2 to 6 hours per day
• Atropine (nl IT, nl USA)
[6]National Guideline Clearinghause (NGC)Best evidence statement (BESt). Treatment of amblyopia in children.AmblyopiaI• Refractive correction (glasses)
• Atropine: 1 drop/day, 2 - 7 days per week (nl IT, nl USA)
• Patching: from 2 to 6 hours per day
[38]Royal College of OphthalmologistsGuidelines for the management of strabismus in childhoodStrabismusIII• Surgical interventions
• Refractive correction (glasses)
• Miotics (not specified)
[46]The Brazilian Society of Pediatrics, Brazilian Council of Ophthalmology, Brazilian Society of Pediatric OphthalmologyBrazilian guidelines proposal for screening and treatment of retinopathy of prematurity (ROP)Retinopathy of prematurity (ROP)IIISurgical interventions+post surgical treatment with topical steroids/antibiotics (not specified)Brazil2007
[40]Royal College of Ophthalmologists, Royal College of Paediatrics and Child Health, British Association of Perinatal Medicine & BLISSGuideline for the Screening and Treatment of Retinopathy of PrematurityRetinopathy of prematurity (ROP)IIIScreening examination with Cyclopentolate 0.5%/Phenylephrine 2.5% combination: 1drop each in 2 to 3 doses, each 5 minutes apart, 1 hour prior to examination (nl)UK2008

NOTE: nl: not licensed for paediatric use; IT: Italy; UK: United Kingdom; USA: United States of America