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Logo of anclinmicBioMed CentralBiomed Central Web Sitesearchsubmit a manuscriptregisterthis articleAnnals of Clinical Microbiology and Antimicrobials
 
Ann Clin Microbiol Antimicrob. 2012; 11: 6.
Published online Mar 11, 2012. doi:  10.1186/1476-0711-11-6
PMCID: PMC3324387
Successful salvage therapy with Daptomycin for osteomyelitis caused by methicillin-resistant Staphylococcus aureus in a renal transplant recipient with Fabry-Anderson disease
Ennio Polilli,1 Tamara Ursini,2 Elena Mazzotta,3 Federica Sozio,3 Vincenzo Savini,1 Domenico D'Antonio,1 Michelino Barbato,4 Augusta Consorte,3 and Giustino Parruticorresponding author3,5
1Microbiology and Virology Unit, Pescara General Hospital, Pescara, Italy
2Clinic of Infectious Diseases, G. D'Annunzio University, Chieti, Italy
3Infectious Disease Unit, Pescara General Hospital, Pescara, Italy
4Orthopedics Unit, Ortona Hospital, Ortona, Italy
5Infectious Disease Unit, Pescara General Hospital, Via Fonte Romana, 8, Pescara 65124, Italy
corresponding authorCorresponding author.
Ennio Polilli: e.polilli/at/libero.it; Tamara Ursini: tamara.ursini/at/gmail.com; Elena Mazzotta: elena.mazzotta/at/libero.it; Federica Sozio: phoede/at/hotmail.it; Vincenzo Savini: vincsavi/at/yahoo.it; Domenico D'Antonio: domenicodantonio/at/virgilio.it; Michelino Barbato: michele.barbato/at/libero.it; Augusta Consorte: augusta.consorte/at/gmail.com; Giustino Parruti: parruti/at/tin.it
Received January 5, 2012; Accepted March 11, 2012.
Abstract
Daptomycin is licensed in adults for the management of Staphylococcus aureus methicillin-resistant infections, including bone and skin complicated infections. We describe for the first time its use in a renal transplant recipient for Fabry-Anderson Disease with right heel osteomyelitis. The patient was unresponsive to first-line Teicoplanin and second-line Tigecycline, whereas he was successfully treated with third-line Daptomycin monotherapy at 4 mg/Kg/qd for 4 weeks. Local debridement was performed in advance of each line of treatment.
Keywords: Methicillin-resistant Staphylococcus aureus, Osteomyelitis, Daptomycin, Salvage therapy, Antibiotic therapy
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