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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptNIH Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
 
J Dev Behav Pediatr. Author manuscript; available in PMC Apr 1, 2013.
Published in final edited form as:
PMCID: PMC3319865
NIHMSID: NIHMS351571
Behavior Disorders in Extremely Preterm/Extremely Low Birth Weight Children in Kindergarten
Megan N. Scott, PhD,1 H. Gerry Taylor, PhD,1 Mary A. Fristad, PhD,2 Nancy Klein, PhD,3 Kimberly Andrews Espy, PhD,4 Nori Minich, BS,1 and Maureen Hack, MB, ChB1
1Department of Pediatrics, Case Western Reserve University and Rainbow Babies & Children’s Hospital, University Hospitals Case Medical Center, Cleveland, OH
2Department of Psychiatry, The Ohio State University, Columbus, OH
3Department of Education, Cleveland State University, Cleveland, OH
4Department of Psychology, University of Oregon, Eugene, OR, and Developmental Neuroscience Laboratory, University of Nebraska-Lincoln, Lincoln, NE
Corresponding author: H. Gerry Taylor, PhD, W.O. Walker Building, Suite 3150, 10524 Euclid Avenue, Cleveland, OH 44106 USA, Fax: 216-368-6640, hgt2/at/case.edu
Objective
To examine the prevalence of behavior disorders in a 2001–2003 birth cohort of extremely preterm/extremely low birth weight (EPT/ELBW, <28 weeks gestational age and/or <1000 g) children in kindergarten.
Method
We compared 148 EPT/ELBW children to 111 term-born normal birth weight (NBW) classmate controls on reports of psychiatric symptoms obtained from parent interview (P-ChIPS), parent and teacher ratings of behavior (CBCL, TRF, BRIEF), and teacher ratings of social functioning (SSBS-2). Associations of behavior disorders with global cognitive ability and tests of executive function were also examined within the EPT/ELBW group.
Results
Rates of ADHD Combined on psychiatric interview were about twice as high for the EPT/ELBW group than for the NBW group, OR (95% CI)=2.50 (1.34, 4.68), p=.004. The EPT/ELBW group also had much higher rates of teacher-identified disorders in attention, behavior self-regulation, and social functioning, with odds ratios (95% confidence intervals) ranging from 3.35 (1.64, 6.83) to 18.03 (4.12, 78.94), all p’s<.01. ADHD and impaired behavior self-regulation were associated with deficits on tests of executive function but not with global cognitive impairment.
Conclusions
The findings document elevated rates of disorders in attention, behavior self-regulation, and socialization in EPT/ELBW children and suggest that deficits on tests of executive function are associated with some of these disorders. Early identification and intervention for these disorders are needed to promote early adjustment to school and facilitate learning progress.
Continued advances in neonatal intensive care have led to increased rates of survival in extremely preterm or very low birth weight children, with gestational age (GA) <28 weeks or birth weight <1000 g.1 These cohorts are at higher risk than term-born normal birth weight (NBW, ≥37 weeks GA and ≥2500 g) children for developmental problems ranging from neurosensory disorders and global intellectual disability to more subtle disturbances in cognition, learning, and behavior.2,3 Rates of behavior problems are up to four times higher in EPT/ELBW children than in their NBW peers.3,4 The most commonly reported problems are attention deficits, internalizing symptoms (anxiety, depression, withdrawal, somatic complaints), and difficulties in social functioning.27 Externalizing symptoms (oppositional behavior, conduct problems, aggression) are less consistently reported.8,9
Internalizing and externalizing symptoms and problems in self-regulation and social functioning in preterm/low birth weight cohorts have been identified as early as 2 years of age,10,11 suggesting that the behavior difficulties observed in older children may have been present since early childhood. Gray et al.12 found that 21% of their sample of 3-year-old preterm low birth weight children had behavior ratings in the clinical range. Similarly, Rose et al.13 found that 30% of 3-year-old <1500 g birth weight children had elevated ratings of behavior problems compared with 18% of a NBW group. In both of the latter studies behavior problems persisted when children were followed to early school age. Other research has also documented more attention and social problems in preterm children compared with term-born controls at early school age (ages 5 and 6 years).1416
The primary aim of this study was to assess the types and extent of behavior disorders in a 2001–2003 birth cohort of EPT/ELBW children during this first year in school compared with NBW classmate controls. We hypothesized that the EPT/ELBW group would have higher rates of several types of behavior abnormalities compared with NBW controls, including attention deficit/hyperactivity disorder (ADHD), internalizing disorders, and deficits in behavior self-regulation and social functioning.3,4,1618 We anticipated higher rates of these disorders in the EPT/ELBW group even when excluding children with neurosensory deficits or low global cognitive ability.
A secondary aim was to determine if impairments in tests of global cognitive ability or executive function increase the risk for behavior disorders in EPT/ELBW children at school entry. Executive function consists of skills that support goal-directed behavior, including response inhibition, mental flexibility, and working memory.19,20 Deficits in these skills are common in EPT/ELBW children and are observed even in children without global cognitive impairment.1921 Based on findings relating performance on tests of global cognitive ability and executive function to behavior outcomes in preterm samples,15,2224 we hypothesized that deficits on these measures would be associated with higher rates of behavior and social difficulties.
To our knowledge no study has examined behavior outcomes in EPT/ELBW children all of whom were attending kindergarten for the first time. By focusing on first-time kindergarteners we were able to document behavior problems evident at this critical transitional period and ensure that the children were at a similar stage of schooling. Awareness of behavior problems is especially important at school entry because of their association with subsequent learning difficulties and the opportunities this awareness provides for earlier and more effective interventions.25,26 Kindergarten is the first year that many children are expected to meet more formal expectations for behavioral self-control and the first opportunity for children who have not been previously identified with special needs to receive assessment and intervention services. This is also one of the few studies to examine behavior problems using a psychiatric interview and ratings of behavior self-regulation and social functioning.1518 Other unique features include appraisal of outcomes in terms of both rates of behavior disorders and symptom severity and examination of deficits on executive function tests as indicators of increased risk for these disorders.
Sample
The EPT/ELBW group consisted of children with <28 weeks GA and/or <1000 g birth weight born between 2001 and 2003 and treated in the neonatal intensive care unit of Rainbow Babies & Children’s Hospital in Cleveland, Ohio. Of the 198 children without congenital abnormalities or infections who survived, 148 (75%) were recruited for this study. Reasons for nonparticipation included failure to locate families (n=21), moves out of the region (n=16), refusal to participate or no-shows (n=5), and questions regarding child custody or non-English-speaking families (n=8). Comparison of participants to the 50 survivors who did not participate did not indicate differences in sex, race, or neonatal characteristics. Recruitment was staggered across several years so that all children could be assessed during their first year in kindergarten. Most of the children were in regular education classrooms (n=129) with a minority either in full-time special education programs (n=16) or home-schooled (n=3).
The comparison group was composed of 111 term-born NBW children recruited from the same classrooms as the EPT/ELBW children (n = 93) or from other kindergarten classrooms (n = 18). To recruit controls, flyers were sent home to parents of all classmates of EPT/ELBW children attending regular classrooms. Once parents had granted permission for study contact, we recruited the student who most closely matched each EPT/ELBW child based on sex, age at testing, and ethnicity. The priority in matching was to recruit an NBW child of the same sex and similar age at testing as the EPT/ELBW child, with matching on ethnicity nearly always achieved after matching on these factors. Controls were not recruited for EPT/ELBW children who were home-schooled (n=3) or attending full-time special education programs (n=16). The reason for these exclusions was to ensure that teacher ratings would be completed by persons aware of age standards for behavior and social skills. Controls were not identified for an additional 18 EPT/ELBW children attending regular classrooms due to school or teacher refusals (n=6), difficulties in identifying appropriate matches (n=7), or locations too distant from the medical center (n=5).
Table 1 summarizes neonatal and demographic characteristics for the EPT/ELBW and NBW groups. The groups did not differ significantly in sex, race, age at assessment, time in school when teacher ratings were completed, or socioeconomic status (SES) as defined by a mean of the sample z scores for maternal education, caregiver occupation (averaged for two-parent households),27 and census-based median family income.28 As reported previously,29 more EPT/ELBW children compared with NBW controls had early interventions services (83% vs. 13%, p<.001) but the groups were similar in rates of participation in daycare (49% vs. 51%) and preschool (84% vs. 85%).
Table 1
Table 1
Perinatal and Demographic Characteristics of the EPT/ELBW and NBW Groups.
Procedures and Measures
Children were given tests of global cognitive ability and executive function while parents completed child behavior ratings and a structured psychiatric interview. Following testing, research assistants visited the children’s schools to obtain teacher ratings of child behavior. Additional kindergarten assessments of the child’s academic achievement and neuropsychological skills completed as part of the larger study revealed deficits in the EPT/ELBW group relative to NBW controls in academic achievement and a broad range of neuropsychological skills.29,30 Information on birth weight status was not shared with child examiners or teachers. However, because research assistants who conducted parent interviews also were responsible for recruitment, interviewers were not masked to birth status. The research was approved by the institutional review board of University Hospitals Case Medical Center and informed parental and teacher consent were obtained in writing prior to participation.
Child behavior ratings included the Child Behavior Checklist and Teacher’s Report Form (CBCL and TRF),31 parent and teacher versions of the Behavior Rating Inventory of Executive Function (BRIEF-parent and BRIEF-teacher),32 and School Social Behavior Scales, 2nd Edition (SSBS-2).33 Each of these scales has documented reliability and validity in identifying behavior problems in clinical populations. The CBCL and TRF survey a broad range of behavior and social-emotional problems whereas the BRIEF assesses behavioral indications of difficulties in executive function and self-regulation at home and school. The BRIEF consists of two composite indices. The Behavioral Regulation Index (self-regulation) comprises the subscales Inhibit (controlling impulses), Shift (shifting attentional focus), and Emotional Control (modulating emotional responses). The Metacogition Index (organizational and self-monitoring skills) comprises the subscales Initiate (beginning activities), Working Memory (keeping information in mind while completing activities), Plan/Organize (using strategies for attaining goals), Organization of Materials (keeping belongings tidy), and Monitor (checking work and being aware of effects of one’s own behavior). The SSBS-2 is a teacher rating of two composite dimensions of student behavior. Social Competence comprises the subscales Peer Relations (e.g., interacts, joins in), Self-Management/Compliance (e.g., cooperates, controls feelings), and Academic Behavior (e.g., listens, completes work). Antisocial Behavior comprises the subscales Hostile (e.g., disrespects others, has tantrums), Antisocial/Aggressive (e.g., aggressive, gets into trouble), and Defiant/Disruptive (e.g., demanding, impulsive).
Disorders on the CBCL and TRF were defined as age- and sex-based T-scores falling in the borderline clinical range or above on DSM-Oriented scales (≥93rd percentile). Disorders on the BRIEF were defined as age and sex-based T-scores of potential clinical significance (≥65) on the composite indices and subscales. Abnormal ratings on the SSBS-2 were identified by age-related percentiles in the at-risk or high-risk range on the composite scales and subscales. Higher scores on SSBS-2 Social Competence scale and subscales reflect higher functioning whereas higher scores on all other behavior measures reflect more problems.
The Children’s Interview for Psychiatric Syndromes-Parent Form (P-ChIPS) was also administered to assess childhood behavioral, anxiety, and mood disorders and other syndromes using a highly structured “yes-no” question format.34 Compared with clinical diagnoses, the P-ChIPS has an average sensitivity and specificity of .87 and .76, respectively, across diagnostic categories.3539 This measure was developed for use with children 6–18 years of age but is appropriate for slightly younger children who attend school. The P-ChIPS provides information on the presence/absence of disorder and symptom count for each syndrome. Cut-offs for clinical syndromes are based on DSM-IV criteria for symptoms counts and duration. The P-ChIPS uses a highly structured format that allows for administration by research assistants with appropriate training. Examiners were trained to reliability in administration of the P-ChIPS and scoring reliability was confirmed by review of a random selection of 25 video-taped interviews, with 96%–100% agreement on the presence/absence of syndromes and 92%–100% agreement on symptoms counts.
Symptom counts and T-scores were correlated (p<.05) for the majority of the corresponding scales of the P-ChIPS, CBCL, and TRF (e.g., ADHD, Oppositional Defiant Disorder/Problems) (Pearson r’s .22–.71), as were T-scores for corresponding scales of the BRIEF-parent and BRIEF-teacher (Pearson r’s .16–.39). There was also significant agreement in the corresponding disorders identified by the three measures (Kappa’s .11–.46). The modest associations between the measures suggest distinct but related measures of behavior.
Global cognitive ability was estimated by the Brief Intelligence Assessment score (BIA) from the Woodcock Johnson Tests of Cognitive Abilities, 3rd edition.40 The BIA is an age-standardized score with good reliability that correlates with other measures of general intelligence.40 As previously reported,30 the EPT/ELBW group had a lower BIA than the NBW group (p<.001), with adjusted means (standard errors) of 87.69 (1.57) and 103.91 (1.81), respectively.
Tests of executive function included measures of inhibition, mental set switching, and working memory developed by one of the authors (KAE) and her colleagues for use with young children.41,42 Shape School requires naming colored shapes drawn as cartoon-like figures according to different rules (e.g., name only the smiling characters but not the frowning ones to assess inhibition, and name the colors of the ones with hats and the shapes of those without hats to assess set switching). Preschool Trails Test—Revised requires finding and stamping pictures of different sized dogs and their correspondingly sized bones in order. Inhibition on this task is assessed by having the child ignore the bones or other stimuli while stamping just the dogs, and set switching is assessed by having the child alternate between stamping the dogs and their bones. Performance on Shape School and Preschool Trials-Revised is assessed in terms of efficiency scores that take into account both errors and completion time. The Test of Inhibition and Attention is a computerized task requiring pressing of the space bar to pictures of fish (targets) but not to pictures of sharks (non-targets). The task involves two conditions, one in which non-targets are rare to assess inhibition (Go No-Go) and the other in which non-targets are frequent to assess selective attention (Continuous Performance Test). The score for each condition is the child’s ability to detect the target (d') as measured by signal detectability theory. Nebraska Barnyard is a measure of working memory that requires children to reproduce sequences of names read by the examiner by touching corresponding locations on a computer screen. Sequences are presented in increasing lengths and the child’s score is the maximum length retained. Our previous report provides further details on these procedures and documents deficits in the EPT/ELBW group compared with NBW controls on each of the tests.30
Data Analysis
Logistic regression was used to examine group differences in rates of disorders controlling for the effects of sex, SES, and race. Moderating effects of sex and SES were explored by including interactions of these factors with group in initial models. Three series of secondary group comparisons were also conducted. In the first series children with neurosensory disorders or a deficit in global cognitive ability as defined by BIA scores below the 10th percentile for age (standard score <81) were excluded. The aims of these analyses was to determine if group differences could be demonstrated in children without more severe or pervasive impairments. In the second series, the 19 EPT/ELBW children who were home schooled or in full time special education programs were excluded to investigate outcomes for EPT/ELBW children attending regular classrooms. The final series was limited to measures for which there were comparable parent and teacher forms (CBCL and TRF, BRIEF-parent and BRIEF-teacher). Only children who had ratings from both parents and teachers were included in these comparisons to determine if parent and teacher ratings would yield similar findings. Mann Whitney U tests were also conducted to examine dimensional differences on P-ChIPS symptom counts and T-scores for the parent and teacher ratings scales (the non-normal distribution of these scores precluded use of parametric tests). In a final series of analyses, logistic regressions controlling for sex, race, and SES were conducted to examine associations of deficits in global cognitive ability and in executive function with behavior disorders in the EPT/ELBW group. The latter deficits were defined as scores below the 10th percentile for the NBW group. Because comparisons were made on multiple behavior measures an alpha of .01 was applied.
Group Differences in Rates of Disorders
Based on parent report, the EPT/ELBW group had higher rates of ADHD Hyperactive-Impulsive and Combined syndromes and of significant elevations on two BRIEF-parent Metacognition scales (Table 2) compared with NBW controls. The EPT/ELBW group also had higher rates disorders on the ADHD Inattentive scale of the TRF, all BRIEF-teacher Metacognition scales, and SSBS-2 Social Competence, Peer Relations, and Academic Behavior (Table 3). The rates of these disorders in the EPT/ELBW group were about double those found in NBW controls for P-ChIPS ADHD diagnoses, nearly five times higher for the ADHD Inattentive on the TRF, and more than five times higher for some scales of the BRIEF-parent, BRIEF-teacher, and SSBS-2. More EPT/ELBW children (n=44, 31%) than NBW controls (n=12, 11%) had multiple P-ChIPS diagnoses, odds ratio (95% confidence interval) = 3.64 (1.79, 7.42), p<.001.
Table 2
Table 2
Rates of parent-reported behavior disorders in the EPT/ELBW (n = 148) and NBW (n =111) groups.
Table 3
Table 3
Rates of teacher-reported behavior disorders in the EPT/ELBW (n = 110 of 148) and NBW (n = 107 of 111) groups.a
Based on teacher reports, group differences in rates of several disorders remained significant in analyses that excluded children with neurosensory disorders or a deficit in global cognitive ability, as well as in analyses that excluded the EPT/ELBW children not in regular classrooms (see Table 3 notations). Group comparisons on the CBCL, TRF, BRIEF-parent, and BRIEF-teacher that included only children with both the parent and teacher ratings revealed differences only on the teacher scales.
Analysis failed to indicate moderating effects of sex or SES on group differences. However, males had higher rates of disorders on the SSBS-2 Self Management/Compliance and Antisocial Behavior scales than females. In addition, lower SES was associated with a higher rate of ADHD Hyperactive-Impulsive on the P-ChIPS and minority race with higher rates of disorders on the BRIEF-parent Metacognition Index and BRIEF-teacher Working Memory scale.
Group Differences in Dimensional Measures of Behavior and Social Functioning
Findings from analyses of symptom counts and T-scores revealed group differences that corresponded in large part to those found in comparing the groups on rates of disorders (Table 4). However, these analyses also revealed group differences not evident in examining rates of disorder, including higher symptom counts for the EPT/ELBW group on P-ChIPS ADHD Inattentive, Oppositional Defiant Disorder, and Enuresis; higher T-scores on the ADHD Attention Problems scale of the CBCL, Affective Problems scale of the TRF, Behavior Regulation Index and Inhibit and Shift scales of the BRIEF-teacher, and Defiant/Disruptive subscale of the SSBS-2; and lower T-scores on the Self Management/Compliance subscale of the SSBS-2.
Table 4
Table 4
Significant differences (p<.01) between the EPT/ELBW (n = 148) and NBW (n = 111) groups in non-parametric comparisons of symptom counts and T-scores.a
Several of the differences remained significant when excluding children with neurosensory disorders or a deficit in global cognitive ability (see Table 4 notations). With these children excluded, the EPT/ELBW also had higher T-scores for Anxiety Problems on the TRF. Several differences also remained significant when excluding EPT/ELBW children not in regular classrooms. A similar pattern of group differences was evident in comparisons on the CBCL, TRF, BRIEF-parent, and BRIEF-teacher that were restricted to children with both parent and teacher ratings.
Association of Test Deficits with Behavior Disorders in the EPT/ELBW Group
Results from logistic regressions failed to reveal associations of deficits on the BIA in the EPT/ELBW group with rates of disorder on any of the behavior or social measures. However, deficits on tests of executive function were associated with higher rates of ADHD Combined, ADHD Inattentive, and Enuresis on the P-ChIPS and with higher rates of T-scores ≥65 on several of the BRIEF-parent and BRIEF-teacher scales (Table 5).
Table 5
Table 5
Executive function test deficits significantly associated (p<.01) with behavior disorders in the EPT/ELBW group.
As EPT/ELBW children reach school age, it is important to identify the types of behavior and social impairments they have at school entry. Evaluations conducted during the kindergarten year in school indicated that the EPT/ELBW group had higher rates of ADHD and deficits in social functioning at school than NBW classmates. Approximately twice as many EPT/ELBW children compared with NBW controls met criteria for diagnoses of ADHD Hyperactive-Impulsive (28% vs. 13%) and ADHD Combined (33% vs. 16%) on a structured psychiatric interview. Teacher ratings in the clinical range on the ADHD Inattentive scale were nearly five times higher in the EPT/ELBW group (19% vs. 4%). The rates of these disorders are comparable to those reported in other studies.15 The EPT/ELBW group also had higher rates of problems in behavioral organization and self-monitoring (i.e., metacognition). Group differences in rates of disorders in metacognition and social functioning remained significant when excluding children with neurosensory disorders or a deficit in global cognitive ability, indicating increased risks for these disorders even among EPT/ELBW children without pervasive impairment.
The EPT/ELBW group had more psychiatric symptoms and higher ratings of behavior or social problems on scales that failed to reveal group differences in rates of disorder. Specifically, the EPT/ELBW group had more parent-reported symptoms of ADHD-Inattentive, Oppositional Defiant Disorder, and enuresis and higher teacher ratings of emotional disturbance, problems in behavior self-control, and defiant/disruptive behaviors. These results confirm both internalizing and externalizing behavior problems in this population. Dimensional differences on several measures of behavior problems, metacognition, and social functioning remained significant when excluding children with neurosensory disorders or a deficit in global cognitive ability. The results are consistent with other evidence for subclinical elevations in behavior and social problems in EPT/ELBW children.3,4,9,43
The types of behavior and social disorders found in this sample have been identified in previous research on EPT/ELBW children conducted at early school age.1416 The present study demonstrates that these disorders continue to be evident even in children born in the early 2000s, a period during which rates of neurodevelopmental impairment have declined.44 Past studies document similar disorders in both younger and older preterm children,4,6,7,1013,22,24,45 suggesting that behavior problems emerge early in childhood and persist over time. The EPT/ELBW group’s higher rate of ADHD Inattentive but not ADHD Hyperactive/Impulsive or Oppositional Defiant Problems on the TRF is also consistent with past observations of more problems in attention than in hyperactivity or externalizing behaviors, especially on teacher reports.37,9,2224 In addition, however, the EPT/ELBW group had a higher rate of ADHD Hyperactive-Impulsive on the P-ChIPS, higher symptom counts for Oppositional Defiant Disorder on the P-ChIPS, and higher teacher ratings of Defiant/Disruptive problems. The results accord with those of Samara et al.15 in documenting a wide range of behavior problems in EPT/ELBW children at early school age.
Many of the group differences remained significant when considering only EPT/ELBW children in regular classrooms, providing new evidence that even those EPT/ELBW children attending regular classes have more behavior problems than their classmates. In comparisons restricted to the subset of children in regular classrooms with both parent and teacher ratings, higher rates of behavior problems were more evident on the teacher ratings. Specifically, on rating scales with comparable parent/teacher forms (CBCL vs. TRF, BRIEF-parent vs. BRIEF-teacher), inattentiveness and problems in behavioral self-regulation were more often identified by teachers. The results suggest that teacher ratings, while generally consistent with those by parents, may be more likely to identify disorders in these areas at school entry and support efforts to obtain reports from both sources.
As observed in previous research, behavior problems were more prevalent in boys than in girls and in children with lower vs. higher SES.7,9,46 Contrary to some previous investigations,9,15 we did not find that the effects of extreme prematurity on behavior were more pronounced for boys than girls. The lack of a moderating effect of sex on group differences was unexpected given evidence for a greater vulnerability of males to complications of preterm birth and early childhood neurodevelopmental impairment,47 though other studies have reported similar findings.7,22,24
Performance of EPT/ELBW children on tests of executive function was related to diagnoses of ADHD Inattentive, ADHD Combined, and Enuresis as well as to behavioral indications of executive dysfunction. Contrary to several past studies,14,15,18,2224 lower global cognitive ability was not associated with behavior or social problems in this EPT/ELBW cohort. This pattern of results suggests that executive function skills are more closely related to attention disorders in EPT/ELBW children than is overall intelligence.3 Recent findings showing that deficits on tests of executive function are associated with ratings of inattentive and overactive/impulsive behaviors in older preterm children support this interpretation.23 Deficits in executive function skills have been identified in children with a wide range of clinical conditions and are viewed by many as being integral components of ADHD.4851 Associations of tests of executive function with enuresis suggest that weaknesses in executive function either contribute directly to lack of bladder control or signal abnormalities in brain regions underlying this disorder.
To our knowledge this is the first study to document behavior and social outcomes of extreme prematurity in a sample of EPT/ELBW children all of whom were enrolled in kindergarten at the time of assessment. The data provide information on the likelihood of clinically relevant levels of behavior and social problems in our sample relative to base rates for peers from similar sociodemographic backgrounds. This study is also one of few to assess behavior self-regulation and social functioning at school, use a formal psychiatric interview to assess behavior outcomes,9 and investigate performance on tests of executive function in relation to behavior outcomes in young EPT/ELBW children. One advantage of using a structured psychiatric interview is that questioning is focused on behaviors that are relevant to diagnostic criteria. A further benefit is that the interview format helps to ensure parent understanding of questions and provides opportunities to clarify parent responses. The utility of the P-ChIPS was demonstrated in this study by its sensitivity to group differences in rates of ADHD diagnoses and the relation of these diagnoses to deficits on tests of executive function.
One of the study’s limitations is that we were unable to recruit 25% of the surviving birth cohort of EPT/ELBW children treated at a single perinatal center. The absence of differences in background and neonatal status of the participants and non-participants suggests that the sample was representative of our regional population. However, behavior outcomes in our largely urban sample may not be representative of outcomes in other regions. Another concern is that the examiners who administered the P-ChIPS were not blind as to birth status. The P-ChIPS is a highly structured interview, syndromes identified on interview were related to corresponding DSM-Oriented syndromes obtained from parent ratings of behavior, and inter-rater reliability for scoring of parent responses was high. Nevertheless, we cannot rule out the possibility that examiner bias contributed to group differences. A further limitation was the failure to include a measure of autism spectrum disorders, especially in view of recent findings suggesting increased symptoms of autism in EPT/ELBW children.3,4,22 Teacher ratings confirm elevated rates of social deficits in the EPT/ELBW group. Although social deficits are also associated with ADHD and deficits in executive function,52,53 it is unclear how many children met criteria for autism.
In summary, the results confirm adverse behavior and social consequences of extreme prematurity at school entry. These consequences are evident both at home and at school and include increased rates of ADHD, impaired social functioning, and poor self-control. The high rates of these disorders in kindergarten underscores the importance of screening EPT/ELBW children for behavior problems when they first enter school if not before.54 Recognition of these disorders at school entry would assist parents and teachers in setting realistic expectations for the child and facilitate more timely behavior interventions. Early interventions are likely to be more effective than later ones and may mitigate the negative effects of behavior and social problems in kindergarten on children’s subsequent academic learning.25,26 The findings also demonstrate associations of tests of executive function with disorders in attention and self-regulation in EPT/ELBW children. These associations demonstrate the utility of neuropsychological assessments in identifying children at risk for behavior disorders. Ongoing follow-up of our sample will help establish the stability of children’s behavior disorders and their relation to subsequent academic progress. Based on previous findings we anticipate that attention disorders in kindergarten will forecast later problems in reading and mathematics.55
Further efforts will be required to examine even earlier manifestations of behavior problems in this population and to design follow-up programs that help to insure that these problems are recognized as soon as they become evident and provide for continuity of care from birth through school age. A system of care such as a “medical home” would serve this purpose56 and neuropsychological follow-up would be useful in tracking development. Additional research is also needed to examine biological and environmental risk factors, explore the neural basis of these problems and other developmental antecedents (e.g., social cognition and communication skills), and test behavior interventions.
ACKNOWLEDGEMENTS
This work was funded by grant HD050309 from the National Institutes of Health, which provided financial support for the design and conduct of the study. We also acknowledge the contributions of Anne Birnbaum, Dr. Elizabeth Roth, Dan Maier, Andrea Barkoukis Gefteas, Michelle R. Jacobs, Alice Costiuc, and Ketrin Lengu in recruitment and data collection and coding.
Footnotes
This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Conflicts of Interest: An author is one of the developers of the psychiatric interview used in this study and receives royalities from the sale of this measure.
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