No consistent evidence for association between mtDNA variants and Alzheimer disease
From the Institute of Genetic Medicine (G.H., P.F.C.), Newcastle University, Central Parkway, Newcastle upon Tyne, UK; and Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology (R.S., D.H., J.C., P.H., A.G., G.R., M.H., V.K., N.J., C.T., A.S., P.A.H., M.C.O., M.J.O., J.W.), School of Medicine, Cardiff University, Cardiff, UK.
1Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK.
2Department of Neuroscience, Institute of Psychiatry, Kings College London, London, UK.
3Institute of Public Health, University of Cambridge, Cambridge, UK.
4Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.
5Mercer's Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland.
6Institute of Genetics, Queen's Medical Centre, University of Nottingham, NG7 2UH, UK.
7Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, UK.
8Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK.
9Clinical Neuroscience Research Group, Greater Manchester Neurosciences Centre, University of Manchester, Salford, UK.
10Oxford Project to Investigate Memory and Ageing (OPTIMA), University of Oxford, Level 4, John Radcliffe Hospital, Oxford OX3 9DU, UK.
11Dementia Research Group, University of Bristol Institute of Clinical Neurosciences, Frenchay Hospital, Bristol, UK.
12Department of Molecular Neuroscience and RetaLilla Weston Laboratories, Institute of Neurology, London, UK.
13MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
14Dementia Research Centre, Department of Neurodegenerative Diseases, University College London, Institute of Neurology, London, UK.
15Department of Psychiatry, University of Bonn, Sigmund-Freud-Straβe 25, 53105 Bonn, Germany.
16Institute of Primary Medical Care, University Medical Center Hamburg-Eppendorf, Germany.
17Department of Psychiatry, Charité Berlin, Germany.
18Department of Psychiatry, University of Erlangen, Nürnberg, Germany.
19LVR-Hospital Essen, Department of Psychiatry and Psychotherapy, University Duisburg-Essen, Germany.
20Institute for Stroke and Dementia Reserach, Klinikum der UniversitätMünchen, Marchioninistr. 15, 81377, Munich, Germany.
21Department of Neurology, Klinikum der UniversitätMünchen, Marchioninistr.15, 81377, Munich, Germany.
22Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.
23Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Laboratory of Neuroimaging & Biomarker Research, Trinity College, University of Dublin, Ireland.
24Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig-Maximilian University, Munich, Germany.
25Centre for Geriatric Medicine and Section of Gerontopsychiatry and Neuropsychology, Medical School, University of Freiburg, Germany.
26Departments of Psychiatry, Neurology and Genetics, Washington University School of Medicine, St Louis, MO 63110, US.
27Department of Biology, Brigham Young University, Provo, UT, 84602, USA.
28Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerpen, Belgium.
29Institute Born-Bunge and University of Antwerp; Antwerpen, Belgium.
30Memory Clinic and Department of Neurology, ZNA Middelheim, Antwerpen, Belgium.
31Department of Mental Health Sciences, University College London, UK.
32The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
Received July 26, 2011; Accepted November 14, 2011.