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Logo of anclinmicBioMed CentralBiomed Central Web Sitesearchsubmit a manuscriptregisterthis articleAnnals of Clinical Microbiology and Antimicrobials
 
Ann Clin Microbiol Antimicrob. 2012; 11: 5.
Published online 2012 February 24. doi:  10.1186/1476-0711-11-5
PMCID: PMC3316130
Copyright ©2012 Konaté et al; licensee BioMed Central Ltd.
Antimicrobial activity of polyphenol-rich fractions from Sida alba L. (Malvaceae) against co-trimoxazol-resistant bacteria strains
Kiessoun Konaté,corresponding author1 Adama Hilou,1 Jacques François Mavoungou,2 Alexis Nicaise Lepengué,3 Alain Souza,4 Nicolas Barro,5 Jacques Y Datté,6 Bertrand M'Batchi,3 and Odile Germaine Nacoulma1
1Laboratoire de Biochimie et Chimie Appliquées (LABIOCA), UFR/SVT, Université de Ouagadougou, 09 BP 848 Ouagadougou 09, Burkina Faso
2Institut de Recherche en Ecologie Tropicale (IRET/CENAREST), BP: 13354 Libreville, Gabon
3Laboratoire de Phytopathologie, UFR Agrobiologie, Faculté des Sciences, Université des Sciences et Techniques de Masuku, BP 943 Franceville, Gabon
4Laboratoire de Physiologie Animale, Electrophysiologie et de Pharmacologie, Faculté des Sciences, Université des Sciences et Techniques de Masuku, Franceville, Gabon
5Laboratoire de Biochimie et de Génétique moléculaire microbienne, UFR/SVT, Université de Ouagadougou, 03 BP 7131 Ouagadougou 03, Burkina Faso
6Laboratoire de Nutrition et de Pharmacologie, UFR BioSciences, Université de Cocody, Abidjan 22 BP: 582 Abidjan 22, Côte d'Ivoire
corresponding authorCorresponding author.
Kiessoun Konaté: mehekiessoum/at/yahoo.fr; Adama Hilou: hiloudio/at/gmail.com; Jacques François Mavoungou: mavoungoujacques/at/yahoo.fr; Alexis Nicaise Lepengué: lepengue_nicaise/at/yahoo.fr; Alain Souza: souzapg/at/yahoo.fr; Nicolas Barro: barronicolas/at/yahoo.fr; Jacques Y Datté: dattejy/at/gmx.net; Bertrand M'Batchi: brandtbertachi/at/hotmail.com; Odile Germaine Nacoulma: odilenacoulma/at/yahoo.com
Received December 4, 2011; Accepted February 24, 2012.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Abstract
Background
The increased resistance of microorganisms to the currently used antimicrobials has lead to the evaluation of other agents that might have antimicrobial activity. Medicinal plants are sources of phytochemicals which are able to initiate different biological activities including antimicrobials
Materials and methods
In vitro antibacterial (MIC, MBC and time-kill studies) of polyphenol-rich fractions from Sida alba L. (Malvaceae) was assessed using ten bacteria strains (Gram-negative and Gram-positive).
Results
All test bacteria were susceptible to the polyphenol-rich fractions. Time-kill results showed that after 5 h exposition there was no viable microorganism in the initial inoculum and the effect of polyphenol-rich fractions was faster on Enterococcus faecalis (Gram-positive bacterium) comparatively to the other bacteria strains.
Conclusion
The data analysis indicates that the tested of polyphenol-rich fractions has significant effects when compared with the standard antibiotic. These results therefore justify the traditional use of sida alba L., alone or in combination with other herbs to treat bacterial infections.
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