Search tips
Search criteria 


Logo of plosgenPLoS GeneticsSubmit to PLoSGet E-mail AlertsContact UsPublic Library of Science (PLoS)View this Article
Published online Mar 29, 2012. doi: 10.1371/journal.pgen.1002530
An external file that holds a picture, illustration, etc.
Object name is pgen.1002530.g007.jpg Object name is pgen.1002530.g007.jpg
Figure 7
The location of mutants that disrupt splicing suggests a similarity to exon-definition in mammalian splicing.
A. Spliceosome assembly in mammalian systems is thought to occur via exon-definition, where interactions between U1 and U2 snRNP components across an internal exon, or CPSF components and U2 snRNP across a terminal exon, are necessary for efficient processing of the upstream intron. B. Functional location of a subset of the mutants examined in this work, presented on a model transcript. Factors shown in red caused a statistically significant increase in the precursor levels of at least one transcript in our screen, whereas those in grey did not affect the splicing of any of the transcripts.
Articles from PLoS Genetics are provided here courtesy of
Public Library of Science