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Cold Spring Harb Perspect Med. 2012 April; 2(4): a006171.
PMCID: PMC3312395

The Neuropsychological Profile of Alzheimer Disease

Abstract

Neuropsychological assessment has featured prominently over the past 30 years in the characterization of dementia associated with Alzheimer disease (AD). Clinical neuropsychological methods have identified the earliest, most definitive cognitive and behavioral symptoms of illness, contributing to the identification, staging, and tracking of disease. With increasing public awareness of dementia, disease detection has moved to earlier stages of illness, at a time when deficits are both behaviorally and pathologically selective. For reasons that are not well understood, early AD pathology frequently targets large-scale neuroanatomical networks for episodic memory before other networks that subserve language, attention, executive functions, and visuospatial abilities. This chapter reviews the pathognomonic neuropsychological features of AD dementia and how these differ from “normal,” age-related cognitive decline and from other neurodegenerative diseases that cause dementia, including cortical Lewy body disease, frontotemporal lobar degeneration, and cerebrovascular disease.

Over the past 30 years, neuropsychological assessment has featured centrally in characterizing the dementia associated with Alzheimer disease (AD), identifying the most salient and earliest cognitive and behavioral symptoms and contributing to the staging and tracking of disease (Flicker et al. 1984; Morris et al. 1989; Storandt and Hill 1989; Storandt 1991; Welsh et al. 1991, 1992; Locascio et al. 1995; Albert 1996; Storandt et al. 1998; see also Salmon and Bondi 2009). As research has increasingly focused on earlier stages of illness, it has become clear that biological markers of AD can precede cognitive and behavioral symptoms by years. It has also become clear that the early symptoms of AD represent the selective targeting by disease of specific, “large-scale” neuroanatomical networks, with clinical deficits consistent with the anatomical locus of impact (Weintraub and Mesulam 1993, 1996, 2009; Seeley et al. 2009). In the usual case, AD pathology is initially selective for limbic regions that subserve episodic memory, which leads to a circumscribed memory deficit in the early stages of the disease (Braak and Braak 1991; Jack et al. 1997; de Toledo-Morrell et al. 2000). It is only as pathology progresses to other neocortical regions over time (Braak and Braak 1996a,b; Braak et al. 1999; Jack et al. 2000) that additional cognitive symptoms emerge and the full dementia syndrome becomes apparent.

These discoveries have prompted a revision of the established research diagnostic criteria for AD dementia that had served so well since 1984 (McKhann et al. 1984). The new criteria define not only the dementia of AD (McKhann et al. 2011) but also incorporate a fuller spectrum of cognitive aging, including an intermediate stage of mild cognitive impairment (MCI) that precedes the dementia (Albert et al. 2011). A third, even earlier, stage of “preclinical AD” has also been identified (Sperling et al. 2011). This prodromal period is characterized by the presence of biomarkers, such as brain amyloid deposition and CSF tau and amyloid, that can be detected in vivo in asymptomatic individuals years before the onset of cognitive decline (Perrin et al. 2009; Sperling et al. 2009; Jack et al. 2010). At present, the recommended use of biomarkers to detect AD applies mainly to research. Thus, neuropsychological assessment continues to provide reliable symptom markers of AD that are critical for early diagnosis. The present article describes the profile of neuropsychological deficits associated with the dementia of AD and contrasts it with cognitive changes that occur in “normal” aging and in other forms of neurodegenerative disease that cause dementia.

NEUROPSYCHOLOGICAL DEFICITS IN ALZHEIMER DISEASE

Episodic Memory

The earliest neurofibrillary changes that are part of the pathology of AD usually occur in medial temporal lobe structures (e.g., hippocampus, entorhinal cortex; see Braak and Braak 1991), interrupting the neural network critical for episodic memory function. Thus, it is not surprising that a deficit in the ability to learn and remember new information (i.e., anterograde amnesia) is the clinical hallmark of AD pathology. However, the amyloid pathology that likely occurs years prior to the onset of symptoms (Morris et al. 1996; Reiman et al. 1996; Moonis et al. 2005; Mintun et al. 2006; Becker et al. 2010; De Meyer et al. 2010) is not particularly abundant in medial temporal lobe, but instead in the regions comprising the “default mode network” (Buckner et al. 2005; Sperling et al. 2009). These changes in the default mode network, comprised of a set of functionally interconnected cortical areas (posterior cingulate, inferior parietal lobule, lateral temporal neocortex, ventromedial and dorsomedial prefrontal cortex) that project heavily to medial temporal lobe structures (Buckner et al. 2008), presage cell death in the hippocampus by years.

Numerous studies have shown that patients with AD are impaired on episodic memory tests that use a variety of cognitive procedures (e.g., free recall, recognition, paired-associate learning) across virtually all modalities (e.g., auditory, visual, olfaction) (for review, see Salmon 2000). Evidence from many of these studies suggests that the episodic memory deficit of AD patients is due in large part to ineffective consolidation or storage of new information. Early studies that characterized the episodic memory deficit in AD used word list learning tasks such as those from the Consortium to Establish a Registry for Alzheimer Disease (CERAD) (Welsh et al. 1991) and the California Verbal Learning Test (CVLT) (Delis et al. 1991). These studies consistently showed that AD patients rapidly forget information over time and are equally impaired (relative to age-matched controls) on recognition and free recall components of the tasks. This pattern of performance is consistent with impaired consolidation rather than ineffective retrieval of new information (Delis et al. 1991).

Indices of rapid forgetting have important clinical utility for the early detection and differential diagnosis of AD. Welsh and colleagues (1991), for example, found that the amount of information recalled after a 10-min delay on the CERAD word list learning task differentiated very early AD patients from healthy elderly controls with better than 90% accuracy. This measure was superior in this regard to other measures derived from this task, including immediate recall on each of three learning trials, recognition memory score, and the number of intrusion errors produced throughout the test. Other studies have shown that measures of rapid forgetting can differentiate mildly demented AD patients from healthy elderly controls with ~85%–90% accuracy (Flicker et al. 1984; Butters et al. 1988; Knopman and Ryberg 1989; Morris et al. 1991; Welsh et al. 1991; Tröster et al. 1993). Additional mechanisms contributing to episodic memory impairment in AD include increased sensitivity to interference due to decreased inhibitory processes leading to the production of intrusion errors (Fuld et al. 1982; Jacobs et al. 1990; Delis et al. 1991), and defective use of semantic information to bolster encoding (see Martin et al. 1985; Dalla Barba and Wong 1995; Dalla Barba and Goldblum 1996).

A number of prospective longitudinal studies of cognitive function in nondemented older adults have shown that a subtle decline in episodic memory often occurs before the emergence of the obvious cognitive and behavioral changes required for a clinical diagnosis of AD (Bondi et al. 1994; Jacobs et al. 1995; Linn et al. 1995; Grober and Kawas 1997; Howieson et al. 1997; Small et al. 2000; Backman et al. 2001; Kawas et al. 2003). Some of these studies suggest that memory performance may be poor, but stable, a number of years before the development of the dementia syndrome, and then declines rapidly in the period immediately preceding the AD dementia diagnosis. Small et al. (2000) and Backman et al. (2001), for example, found that episodic memory was mildly impaired 6 yr before dementia onset, but changed little over the next 3 yr. Chen et al. (2001) and Lange et al. (2002) showed a significant and steady decline in episodic memory on delayed recall conditions of word list and story memory tests beginning ~3 yr before the dementia diagnosis in individuals who were either initially asymptomatic or met criteria for MCI at enrollment in these longitudinal studies. Taken together, these studies suggest that an abrupt decline in memory in an elderly individual might better predict the imminent onset of dementia than poor but stable memory ability. These and similar findings led to the development of formal criteria for amnestic MCI (see Petersen et al. 2001), a predementia condition in elderly individuals, which is characterized by subjective and objective memory impairment that occurs in the face of relatively preserved general cognition and functional abilities (for reviews, see Collie and Maruff 2000; Albert and Blacker 2006).

Language and Semantic Knowledge

Mildly demented patients with AD are often impaired on tests of object naming (Bayles and Tomoeda 1983; Martin and Fedio 1983; Bowles et al. 1987; Hodges et al. 1991), verbal fluency (Martin and Fedio 1983; Butters et al. 1987; Monsch et al. 1992), and semantic categorization (Aronoff et al. 2006). The underlying nature of these deficits has been debated (see Nebes 1989) but there is evidence that they reflect deterioration in the structure and content of semantic memory (i.e., general knowledge of facts, concepts, and the meanings of words) that supports language. Knowledge for particular items or concepts and the associations between them may be disrupted as the neuropathology of AD encroaches upon the temporal, frontal, and parietal association cortices in which they are thought to be diffusely stored (for review, see Hodges and Patterson 1995).

Evidence for a deterioration of semantic memory in AD comes from several studies that probed for knowledge of particular concepts across different modes of access and output (e.g., fluency, confrontation naming, sorting, word-to-picture matching, and definition generation). These studies assume that loss of knowledge, as opposed to impaired retrieval of intact knowledge, would lead to consistency of performance across items (Chertkow and Bub 1990; Hodges et al. 1992). For example, if a patient has lost the concept of “horse,” they should not be able to name a picture of a horse, generate “horse” on a verbal fluency test, sort horse into its proper category as a domestic animal, and so on. The results of these studies showed that patients with AD were significantly impaired on all measures of semantic memory and, when a particular stimulus item was missed (or correctly identified) in one task, it was likely to be missed (or correctly identified) in other tasks that accessed the same information in a different way.

Loss of knowledge of the attributes and associations that define a particular semantic category is also thought to reduce the ability of patients with AD to efficiently generate words from a small and highly related set of exemplars during tests of verbal fluency. Thus, patients with AD are more impaired on category fluency (e.g., generating lists of animals) than letter fluency (e.g., generating words beginning with a specific letter) (Butters et al. 1987; Monsch et al. 1992; Henry et al. 2004, 2005). The fact that patients with AD are more impaired on the fluency task that places greater demands on the integrity of semantic memory is consistent with the notion that they have a deterioration in the structure and organization of semantic memory rather than a general inability to retrieve or access semantic knowledge (see also Rohrer et al. 1995, 1999).

Executive Functions, Working Memory, and Attention

Deficits in “executive functions” responsible for the mental manipulation of information, concept formation, problem solving, and cue-directed behavior occur early in the course of AD and are often evident in the MCI stage (Perry and Hodges 1999; Chen et al. 2001). Executive function deficits in addition to difficulties with delayed memory recall predict subsequent progression to AD dementia (Albert 1996). Reduced ability to mentally manipulate information may be a particularly early feature based on a well-controlled study showing that very mildly demented AD patients were significantly impaired relative to cognitively normal controls on tests that required set shifting, self-monitoring, or sequencing, but not on tests that required cue-directed attention or verbal problem solving (Lefleche and Albert 1995). A number of other studies have similarly shown that AD patients are impaired on difficult problem-solving tests that require mental manipulation such as the Tower of London puzzle (Lange et al. 1995), the modified Wisconsin Card Sorting Task (Bondi et al. 1993), tests of relational integration (Waltz et al. 2004), and other tests of executive functions such as the Porteus Maze Task, Part B of the Trail-Making Test, and the Raven Progressive Matrices (Grady et al. 1988). These deficits in executive functioning have been hypothesized to reflect AD pathology, especially neurofibrillary tangle burden, in prefrontal cortex. This regional prefrontal cortex pathology is particularly pronounced in a subset of AD patients who present early on with predominant executive dysfunction (Johnson et al. 1999; Waltz et al. 2004). This again highlights the impact of anatomical specificity of pathology on the disruption of distinct neocortical networks.

The deficit in mental manipulation exhibited by patients with AD may also be expressed on tests of working memory. “Working memory” refers to a processing system whereby information that is the immediate focus of attention is temporarily held in a limited-capacity, language- or visually-based, immediate memory buffer while being manipulated by a “central executive” (Baddeley 2003). Studies indicate that the working memory deficit of patients with AD is initially mild and primarily involves disruption of the central executive with relative sparing of immediate memory (Baddeley et al. 1991; Collette et al. 1999). It is not until later stages of AD that all aspects of the working memory system become compromised (Baddeley et al. 1991; Collette et al. 1999). Consistent with this model, mildly demented AD patients are often impaired on complex attention tasks that are dependent upon the effective allocation of attentional resources (e.g., dual-processing tasks) or that require efficient disengagement and shifting of attention (for reviews, see Parasuraman and Haxby 1993; Perry and Hodges 1999). In contrast, the ability to focus and sustain attention is usually only affected in later stages of the disease. This is apparent in the essentially normal performance of mildly demented AD patients on tests of immediate attention span compared with supraspan tests (Cherry et al. 2002).

Visuospatial Abilities

Patients with AD often exhibit deficits in visuospatial abilities at some point in the course of the disease (for review, see Cronin-Golomb and Amick 2001). It has also been suggested that visuospatial deficits may occur early, even in preclinical stages (Johnson et al. 2009). Changes in visuospatial function are apparent on visuoconstructional tasks and tasks that require visuoperceptual abilities and visual orientation. The visuoperceptual deficit exhibited by patients with AD may arise, in part, from the loss of effective interaction between distinct and relatively intact cortical information processing systems (Morrison et al. 1991). Studies have shown, for example, that when AD patients perform a visual search task to quickly identify targets on the basis of the conjunction of two or more features that are processed in different cortical regions (e.g., color and shape), they have disproportionately greater response times compared to controls than when required to identify targets solely on the basis of a single feature (Treisman 1996; Foster et al. 1999). Subsequent studies showed that this deficit in “feature-binding” (Treisman 1996; Foster et al. 1999) could not be attributed to the different attentional demands inherent in conjunction versus single-feature visual search tasks (Tales et al. 2002) A similar deficit was observed by Festa and colleagues (2005) on a task that required corticocortical integration of motion and color information which is processed in distinct dorsal (motion) and ventral (color) cortical visual information processing “streams.”

Deficits in visual information processing and in selective and divided attention are observed in the course of normal aging but are exacerbated in individuals with AD (Parasuraman et al. 1995, 2000; Greenwood and Parasuraman 1997; Greenwood et al. 1997; Parasuraman and Greenwood 1998). In addition, visual motion detection has been shown to decline in some individuals with MCI, and more so in those with a diagnosis of AD dementia, suggesting that this symptom may constitute an independent marker of those likely to have AD pathology (Mapstone 2003). The narrowing of the window of visuospatial attention has been demonstrated with the Useful Field of View (UFOV) paradigm in which reaction time to peripheral visual targets is measured in the presence of various levels of distracting visual stimuli (Ball et al. 1988). Older individuals react more slowly to peripheral stimuli compared to younger controls, and patients with AD show an even greater impairment. These deficits may account for the increased incidence of car crashes in patients with AD dementia (Rizzo et al. 1997; Ball and Owsley 2003).

Although rare, AD can initially present with relatively circumscribed posterior cortical atrophy (PCA), with dementia dominated by higher order visual dysfunction (see Caine 2004). Despite relatively preserved memory functions, intact language, and preserved judgment and insight, patients with the clinical syndrome of PCA usually have prominent visual agnosia, constructional apraxia, and exhibit some or all of the features of Balint’s syndrome including optic ataxia, gaze apraxia, and simultanagnosia. They may also exhibit components of Gerstmann’s syndrome including acalculia, right–left disorientation, finger agnosia, and agraphia. A visual field defect, decreased visual attention, impaired color perception, or decreased contrast sensitivity may also occur (Della Sala et al. 1996).

The clinical syndrome of PCA is usually associated with AD pathology but may also occur in the presence of neuropathological changes of cortical Lewy body disease or Creutzfeld–Jakob disease. Neuropathologic examination reveals disproportionate atrophy and pathologic lesions in the occipital cortex and posterior parietal cortex (Hof et al. 1997; Renner et al. 2004). Studies using positron emission tomography (PET) have shown particular involvement of the dorsal visual stream (Nestor et al. 2003). In the case of PCA due to AD, neurofibrillary tangles and neuritic plaques in the posterior cortical regions are qualitatively identical to those in typical AD (Hof et al. 1997). The disproportionately posterior cortical distribution of AD pathology in PCA has recently been shown in living patients using PET imaging with Pittsburgh compound-B ([11C]-PIB), an agent that binds to β amyloid in the brain (Tenovuo et al. 2008).

DISTINGUISHING ALZHEIMER DISEASE FROM OTHER CAUSES OF DEMENTIA

Although AD is the leading cause of dementia in the elderly, dementia can arise from a wide variety of etiologically and neuropathologically distinct disorders that give rise to somewhat different patterns of cognitive impairment. Knowledge of these differences might lead to better understanding of the neurobiological basis of normal and abnormal cognition and have important implications for differential diagnosis. Increasingly, AD pathology has been identified following a distribution other than the canonical temporal–limbic trajectory. Progressive visuospatial deficits, executive dysfunction, and aphasia syndromes have been described in association with AD pathology (Hof et al. 1993; Johnson et al. 1999; Mesulam 2008). Clinical criteria have shown diagnostic accuracy for AD (Dubois et al. 2007), but lack specificity in differentiating AD from other dementia syndromes. The lack of differentiation is due, in part, to the fact that, although memory impairment is a hallmark of AD, it may also occur with other neurodegenerative diseases. The remaining sections will review similarities and differences between the cognitive deficits of AD and those of other age-related causes of dementia: dementia with Lewy bodies (DLB), frontotemporal lobar degeneration (FTLD), and vascular dementia (VaD).

Alzheimer Disease versus Dementia with Lewy Bodies

DLB is a clinicopathologic condition characterized by cell loss and the presence of Lewy bodies (α-synuclein positive intracytoplasmic neuronal inclusion bodies) in subcortical regions affected in Parkinson’s disease and diffusely distributed throughout the limbic system and neocortex. In most cases, AD pathology also occurs in the same general distribution as in “pure” AD (Ince et al. 1998). The dementia syndrome of DLB is similar to that of AD and the two disorders are often clinically confused during life (e.g., Hansen et al. 1990; Merdes et al. 2003). However, mild spontaneous motor features of Parkinsonism (e.g., bradykinesia, rigidity, and masked facies, but without a resting tremor), recurrent and well-formed visual hallucinations, and fluctuating cognition with pronounced variations in attention or alertness occur more frequently in patients with DLB than in those with pure AD (for review, see McKeith et al. 2005).

There are subtle differences in the patterns of neuropsychological deficits associated with DLB and AD. Studies comparing clinically diagnosed or autopsy-diagnosed patient groups on batteries of neuropsychological tests suggest that visuospatial, attention, and executive function deficits are more pronounced in DLB than AD (at the same stage of global dementia severity), whereas memory impairment is more pronounced and may be qualitatively different in AD compared to DLB (Hansen et al. 1990; Johnson et al. 2005; Kraybill et al. 2005; Ferman et al. 2006; Guidi et al. 2006; Stavitsky et al. 2006). These studies also suggest that the severity of the visuospatial deficit may be the most salient difference between patients with AD and patients with DLB, perhaps because of significant occipital cortex dysfunction only in the latter group. Studies using PET or SPECT neuroimaging have shown that patients with DLB have hypometabolism and decreased blood flow in primary visual and visual association cortex that is not evident in AD (Minoshima et al. 2001). They also have unique occipital cortex pathology that includes white matter spongiform change with coexisting gliosis (Higuchi et al. 2000), and in some cases deposition of Lewy bodies (e.g., Gomez-Tortosa et al. 2000).

The prominence of the visuospatial deficits in DLB has important clinical utility. In one study, for example, the presence of visual hallucinations was the best positive predictor (positive predictive value: 83%) of DLB (vs. AD) at autopsy, whereas lack of visuospatial impairment was the best negative predictor (negative predictive value: 90%) (Tiraboschi et al. 2006). In another study, Hamilton and colleagues (2008) showed that poor baseline performance on visuospatial tests, but not tests of other cognitive abilities, was strongly associated with a rapid rate of global cognitive decline over the subsequent two years in patients with DLB but not in those with AD. Thus, early severe visuospatial deficits may identify DLB patients who face a particularly malignant disease course.

The memory deficit of patients with DLB is generally less severe than that of patients with AD and may reflect a qualitative difference in the processes affected. This was shown in a study that directly compared the performance of patients with autopsy-confirmed DLB (all with concomitant AD pathology) or with pure AD on the CVLT and the WMS-R logical memory test (Hamilton et al. 2004). Although the two groups were equally impaired in their ability to learn new verbal information on these tests, the DLB patients exhibited better retention and better recognition memory than patients with pure AD. The better retention and recognition memory of the DLB patients suggests that a deficit in retrieval plays a greater role in their memory impairment than in that of patients with AD.

Alzheimer Disease versus Frontotemporal Lobar Degeneration

FTLD encompasses a class of neurodegenerative diseases that share an affinity for the frontal and temporal lobes of the brain and are marked by distinctive neuropathologic features. The dementia syndromes associated with FTLD are characterized by the absence of true amnesia in the early stages. Instead, they can be divided into two broad categories: a language-based dementia referred to as primary progressive aphasia (PPA) (Mesulam 1982, 2001, 2003), and a dementia in which changes in social cognition, behavior and personality mark the earliest stages, known as behavioral variant frontotemporal dementia (bvFTD) (Rascovsky et al. 2007a, 2011).

The earliest characterization of a dementia marked by significant personality changes was initially called “frontal lobe dementia” and shown to be related to Pick’s disease (i.e., neocortical deposition of Pick bodies) and to nonspecific neuropathology designated as “frontal lobe degeneration of non-Alzheimer type” (Brun 1987; Gustafson 1987). Subsequent classification led to the delineation of three syndromes, namely, frontotemporal dementia, progressive nonfluent aphasia, and semantic dementia (Neary et al. 1994, 1998; Neary and Snowden 1996). However, rapid accumulation of information on the neuroimaging and neuropathologic features of these non-AD dementias over the past decade has necessitated further revision of the clinical and neuropathologic diagnostic criteria, which are likely to continue to evolve.

Beginning about 20 years ago, neuropathologic entities associated with FTLD syndromes were designated as either a form of tauopathy or as “dementia lacking distinctive histopathology” (Knopman et al. 1990). As clinical, pathological, and molecular characterization was enhanced over subsequent years, new discoveries led to an increase in the number of pathologic diagnoses that now fall under the rubric of FTLD. At present, the neuropathologic diagnosis is based on the molecular nature of intraneuronal inclusions, which include tarDNA binding protein (TDP-43), fused-in-sarcoma protein (FUS), entities characterized by different molecular forms of tau, and a smaller class of as yet uncharacterized entities (Mackenzie et al. 2010). Genetic mutations in tau, progranulin, valosin-containing protein (VCP) (Watts et al. 2004), and CHMP2B (Skibinski et al. 2005; Holm et al. 2007) have been associated with frontotemporal dementia syndromes. Neuroimaging studies have shown that left perisylvian language regions show the most marked structural changes and salient hypometabolism in patients with PPA (Sonty et al. 2003; Gorno-Tempini et al. 2004), whereas bilateral frontal and anterior temporal atrophy and hypometabolism characterize bvFTD (Whitwell et al. 2004, 2009; Knopman et al. 2009). These patterns are distinct from the well-known medial temporal lobe atrophy (Jack et al. 1997) and bilateral temporoparietal hypometabolism (Foster et al. 1983) associated with typical AD dementia.

Primary Progressive Aphasia

There has been growing interest in PPA since the modern-day description of six patients with “slowly progressive aphasia” (Mesulam 1982). Three variants have been defined, each with a distinctive clinical, neuroanatomic, and neuropathologic profile (Mesulam et al. 2008, 2009; Gorno-Tempini et al. 2011). Nonfluent/agrammatic PPA (PPA-G), is characterized by deficits in grammatical features of language with or without nonfluent speech output. PPA-G has been associated predominantly with FTLD-tauopathy (Mesulam et al. 2008; Grossman 2010). Semantic variant PPA (PPA-S) is characterized by fluent speech production and single word comprehension deficits. PPA-S is mainly associated with the pathology of TDP-43 proteinopathy (Mesulam et al. 2008). PPA-S overlaps with semantic dementia, a disorder in which there are visual processing deficits in addition to aphasia (see Hodges and Patterson 2007). A third variant, logopenic PPA (PPA-L), is characterized by hesitant, grammatically correct speech and spared language comprehension (Gorno-Tempini et al. 2004; Mesulam et al. 2009). PPA-L is most often associated with AD pathology disproportionately distributed in language-related cortical areas (Mesulam et al. 2008). Patients with a familial form of PPA due to a progranulin mutation have been reported to have disproportionate TDP-43 pathology in language-related areas in the left cerebral hemisphere (Gliebus et al. 2009).

As mentioned earlier, anomia and reduced word list generation are features of AD that may be indicative of a more general dissolution of semantic processing. In contrast, anomia and verbal fluency deficits in PPA can occur without associated semantic loss. Early language deficits in PPA also include agrammatism, phonological sequencing deficits, and paraphasias in speech. In typical AD these types of language deficits occur only in advanced stages of disease in which patients may develop frank aphasia against a background of more widespread cognitive dysfunction (Bayles 1982). A greater deficit in naming verbs than naming nouns is associated with nonfluent, agrammatic forms of PPA (Hillis et al. 2004). Verb processing deficits can also occur in AD, but the deficits are linked to impaired processing of the semantic rather than the syntactic information carried by verbs (Grossman et al. 1996; Kim and Thompson 2004).

Neuropsychological studies that directly compared patients with clinically diagnosed PPA, bvFTD, and AD have shown that those with PPA have relatively preserved reasoning and episodic memory compared with the other two groups (Wicklund et al. 2004, 2006). Furthermore, functional ability reflected in activities of daily living (ADL) is better preserved in patients with PPA than in the other two groups when duration of illness is controlled (Wicklund et al. 2007). Perhaps this occurs because the relative preservation of episodic memory and judgment in patients with PPA is less detrimental to complex ADL than aphasia, at least initially. Language deficits are most prominent in PPA early in the course of illness, but also develop and worsen in patients with bvFTD. Language deficits have a more indolent course in AD than in PPA or bvFTD (Blair et al. 2007).

Behavioral Variant Frontotemporal Dementia

The behavioral variant of FTD usually begins insidiously with personality and behavioral changes such as inappropriate social conduct, inertia and apathy, disinhibition, perseverative behavior, loss of insight, hyperorality, and decreased speech output (for reviews, see Miller et al. 1997; Snowden et al. 2001; Rascovsky et al. 2007a; Rabinovici et al. 2008; Caycedo et al. 2009). These changes are followed by cognitive deficits which include alterations in judgment, problem solving, concept formation, and executive functions, often with relative sparing of visuospatial abilities and episodic memory. BvFTD and probable AD can be difficult to distinguish during life because of overlap in symptoms, but it has been suggested that AD is more often associated with constructional deficits than bvFTD. Although recent attempts to differentiate bvFTD and AD on the basis of the nature and severity of behavioral symptoms has met with some success (e.g., Barber et al. 1995, 2000; Miller et al. 1997; Mendez et al. 1998; Bozeat et al. 2000; Kertesz et al. 2000), behavior-based methods are only partially effective and might be improved by considering other aspects of the disorders. This has led some researchers to investigate the possibility that differences in the patterns of cognitive deficits associated with bvFTD and AD might aid in differential diagnosis (Elfgren et al. 1994; Binetti et al. 1996; Mendez et al. 1996; Pachana et al. 1996; Thomas-Anterion et al. 2000; Rascovsky et al. 2002; Kramer et al. 2003). Revised criteria for the clinical diagnosis of bvFTD have recently been validated against pathologically verified FLTD (Rascovsky et al. 2011), which may improve diagnostic accuracy.

Particularly compelling are retrospective studies that have shown a double dissociation in which mildly to moderately demented patients with autopsy-confirmed FTLD are more impaired than those with autopsy-confirmed AD on tests sensitive to frontal lobe dysfunction (e.g., word generation tasks), but less impaired on tests of memory and visuospatial abilities sensitive to dysfunction of medial temporal and parietal association cortices (e.g., Rascovsky et al. 2002; Grossman et al. 2007). In one study, Rascovsky and colleagues (2002) used multivariate analysis of covariance to show that FTLD patients performed significantly worse than AD patients on word generation tasks that are sensitive to frontal lobe dysfunction (particularly letter fluency), but significantly better on tests of memory (i.e., Mattis Dementia Rating Scale [DRS] Memory subscale) and visuospatial abilities (i.e., WAIS Block Design and Clock Drawing tests), which are sensitive to dysfunction of medial temporal and parietal association cortices, respectively. A logistic regression model using scores from letter fluency, the Mattis DRS memory subscale, and the Block Design test correctly classified 91% of AD patients and 77% of FTLD patients. A follow-up study (Rascovsky et al. 2007b) that compared the performance of autopsy-confirmed FTLD and AD patients on letter and semantic category fluency tasks showed that FTLD patients performed worse than AD patients overall and showed similar impairment in letter and semantic category fluency, whereas AD patients showed greater impairment in semantic fluency than letter fluency. A measure of the disparity between letter and semantic fluency (the Semantic Index) correctly classified 26 of 32 AD patients (82%) and 12 of 16 FTLD patients (75%). Interestingly, the few misclassified FTLD subjects all had clinical presentations of PPA. When these cases were excluded, a dissociation was apparent with letter worse than semantic fluency for the FTLD patients and semantic worse than letter fluency for the AD patients. In addition, the Semantic Index now correctly classified 90% of FTD and AD patients. These unique patterns of fluency deficits may be indicative of differences in the relative contribution of frontal lobe–mediated retrieval deficits and temporal lobe–mediated semantic deficits in FTLD and AD, respectively.

Taken together, the results of these studies indicate that distinct cognitive profiles are associated with FTLD and AD and suggest that they might aid in differentiating between the two diseases. This conclusion is supported by several other studies using clinically diagnosed patients that found similar levels of discriminability when differentiating FTD from AD on the basis of tests of executive function, visuospatial abilities, and episodic memory (Elfgren et al. 1994; Gregory et al. 1997; Lipton et al. 2005; Libon et al. 2007). These differences are robust enough to be detected with relatively brief dementia-screening instruments that tap multiple cognitive functions (Mathuranath et al. 2000; Bier et al. 2004; Slachevsky et al. 2004).

Alzheimer Disease versus Vascular Dementia

VaD refers to a cumulative decline in cognitive functioning secondary to multiple or strategically placed infarctions, ischemic injury, or hemorrhagic lesions (for review, see Wetzel and Kramer 2008). Research diagnostic criteria for VaD require that multiple cognitive deficits occur in the presence of focal neurological signs and symptoms and/or laboratory (e.g., CT or MRI scan) evidence of cerebrovascular disease that is thought to be etiologically related to the cognitive impairment (Chui et al. 1992; Roman et al. 1993). A relationship between dementia and cerebrovascular disease is often indicated if the onset of dementia occurs within several months of a recognized stroke, there is an abrupt deterioration in cognitive functioning, or the course of cognitive deterioration is fluctuating or stepwise. The clinical and neuropathologic presentation of VaD is quite heterogeneous and can include multi-infarct dementia (MID) associated with multiple large cortical infarctions, dementia due to strategically placed infarction, and subcortical ischemic vascular dementia due to subcortical small vessel disease that results in multiple lacunar strokes, leukoaraiosis, or diffuse white matter pathology (Hodges and Graham 2001).

Neuropsychological studies largely show that patients with VaD are more impaired than those with AD on tests of executive functions, whereas patients with AD are more impaired than those with VaD on tests of episodic memory (particularly delayed recall) (Desmond et al. 1999; Graham et al. 2004; Reed et al. 2007). Executive dysfunction is often the most prominent deficit in VaD, perhaps because white matter pathology (particularly in subcortical ischemic vascular dementia) interrupts fronto-subcortical networks that mediate this aspect of cognition. Consistent with this possibility, Price et al. (2005) showed that VaD patients with significant white matter abnormality on imaging exhibited greater executive dysfunction and visuoconstructional impairment than memory and language impairment (see also Mathias and Burke 2009, for review).

Unfortunately, cognitive measures appear to be limited in their ability to effectively discriminate between VaD and AD (Mathias and Burke 2009). When neuropsychological profiles were compared in patients with autopsy-confirmed VaD or AD, only 45% of VaD patients exhibited a profile with more prominent executive dysfunction than memory impairment, and 71% of AD patients exhibited a profile with memory impairment more prominent than executive dysfunction (Reed et al. 2007). Studies based on clinically diagnosed groups are even more likely to be inconclusive because of the overlap in the pathology of AD and VaD. Schneider and colleagues (2007), for example, found that 38% of 50 demented patients who came to autopsy had pathological AD plus infarctions, whereas 30% had AD pathology alone. Vascular pathology increased the odds of dementia and exacerbated memory dysfunction in those with AD.

CONCLUSIONS

Neuropsychology has contributed importantly to the characterization of the dementia associated with the neuropathology of AD, its differentiation from cognitive changes accompanying normal aging, and its distinction from dementias associated with other types of neuropathology. The neuropsychological study of AD has advanced our understanding of other diseases that cause dementia, including cortical Lewy body disease, cerebrovascular disease, and FTLD. The very earliest neuropsychological symptoms of a dementia reflect the neuroanatomical systems that bear the load of the associated pathology but the relationship between the symptoms and underlying disease is less obvious (Fig. 1). Amnestic dementia has the highest likelihood of being associated with AD pathology, but early aphasia, progressive visuospatial deficits, and changes in personality can also be associated with AD neuropathology. As dementia progresses from early to late stages, symptom domain boundaries become blurred and distinctive profiles are difficult to discern (Fig. 2). Thus, neuropsychological profiles are most informative in early stages. The development of fluid and neuroimaging biomarkers will no doubt improve diagnosis and ultimately be used to measure treatment effects. However, neuropsychological characterization remains essential to understanding the individual patient’s deficits so that nonpharmacologic interventions can be appropriately applied and so that patient and caregiver educational materials are appropriately targeted (Weintraub and Morhardt 2005).

Figure 1.
The neuropsychological profiles of dementia reflect the impact of disease on distinctive neuroanatomic networks associated with complex cognitive domains. For example, prominent amnesia is associated with medial temporal dysfunction, whereas aphasia is ...
Figure 2.
Three graphs, each schematically representing early- and late-stage cognitive/behavioral profiles of three neuropsychologically distinct dementia syndromes. The height of the bars represents the level of impairment: mild, moderate, or severe. In late ...

ACKNOWLEDGMENTS

The authors wish to acknowledge the following grants: AG13854 (Northwestern Alzheimer’s Disease Core Center) and AG05131 (University of California San Diego Alzheimer’s Disease Research Center), both from the National Institute on Aging.

Footnotes

Editors: Dennis J. Selkoe, Eckhard Mandelkow, and David M. Holtzman

Additional Perspectives on The Biology of Alzheimer Disease available at www.perspectivesinmedicine.org

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