Search tips
Search criteria 


Logo of autoimmdisJournal's HomeManuscript SubmissionAims and ScopeAuthor GuidelinesEditorial BoardHome
Autoimmune Dis. 2012; 2012: 784315.
Published online Mar 14, 2012. doi:  10.1155/2012/784315
PMCID: PMC3312230
The Biological Significance of Evolution in Autoimmune Phenomena
Carlos A. Cañas 1 * and Felipe Cañas 2
1Rheumatology Unit, Fundación Valle del Lili, ICESI University, Avenida Simón Bolívar Cra. 98 No.18-49, Cali, Colombia
2Fundación Valle del Lili, Medical School, Universidad del Valle, Cali, Colombia
*Carlos A. Cañas: cacd12/at/
Academic Editor: Juan-Manuel Anaya
Received September 14, 2011; Accepted December 28, 2011.
It is an inherent part of living to be in constant modification, which are due to answers resulting from environmental changes. The different systems make adaptations based on natural selection. With respect to the immune system of mammals, these changes have a lot to do with the interactions that occur continuously with other living species, especially microorganisms. The immune system is primarily designed to defend from germs and this response triggers inflammatory reactions which must be regulated in order not to generate damage to healthy tissue. The regulatory processes were added over time to prevent such damage. Through evolution the species have stored “an immunological experience,” which provides information that is important for developing effective responses in the future. The human species, which is at a high level of evolutionary immunological accumulation, have multiple immune defense strategies which, in turn, are highly regulated. Imbalances in these can result in autoimmunity.
“There is nothing permanent except change.”
Articles from Autoimmune Diseases are provided here courtesy of
Hindawi Publishing Corporation