PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of bmcpmBioMed Centralsearchsubmit a manuscriptregisterthis articleBMC Pulmonary Medicine
 
BMC Pulm Med. 2012; 12: 6.
Published online Feb 20, 2012. doi:  10.1186/1471-2466-12-6
PMCID: PMC3311562
Interleukin 6, lipopolysaccharide-binding protein and interleukin 10 in the prediction of risk and etiologic patterns in patients with community-acquired pneumonia: results from the German competence network CAPNETZ
Katrin Zobel,1 Peter Martus,2 Mathias W Pletz,3 Santiago Ewig,4 Michael Prediger,1 Tobias Welte,5 and Frank Bühlingcorresponding author5,6, CAPNETZ study group
1Department of Pneumology, Carl-Thiem-Klinikum Cottbus, Thiemstrasse 111, 03048 Cottbus, Germany
2Department of Biometry and Clinical Epidemiologie, Charité, Chariteplatz 1, 10098 Berlin, Germany
3Division of Gastroenterology, Hepatology and Infectious Diseases, Jena University Hospital, Hospital Erlanger Allee 101, 07740 Jena, Germany
4Thoraxzentrum Ruhrgebiet, Respiratory and Infectious Diseases, Ev. Krankenhaus Herne und Augusta-Kranken-Anstalt, Bochum, Thoraxzentrum Ruhrgebiet, Hordeler Strasse 7-9, 44651 Herne, Germany
5Department of Pneumology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany
6Department of Laboratory Medicine, Carl-Thiem-Klinikum Cottbus, Thiemstrasse 111, 03048 Cottbus, Germany
corresponding authorCorresponding author.
Katrin Zobel: katrinkaube/at/web.de; Peter Martus: peter.martus/at/charite.de; Mathias W Pletz: mathias.pletz/at/med.uni-jena.de; Santiago Ewig: sewig/at/versanet.de; Michael Prediger: m.prediger/at/ctk.de; Tobias Welte: welte.tobias/at/mh-hannover.de; Frank Bühling: frank/at/buehling.net
Received July 12, 2011; Accepted February 20, 2012.
Abstract
Background
The aim of our study was to investigate the predictive value of the biomarkers interleukin 6 (IL-6), interleukin 10 (IL-10) and lipopolysaccharide-binding protein (LBP) compared with clinical CRB and CRB-65 severity scores in patients with community-acquired pneumonia (CAP).
Methods
Samples and data were obtained from patients enrolled into the German CAPNETZ study group. Samples (blood, sputum and urine) were collected within 24 h of first presentation and inclusion in the CAPNETZ study, and CRB and CRB-65 scores were determined for all patients at the time of enrollment. The combined end point representative of a severe course of CAP was defined as mechanical ventilation, intensive care unit treatment and/or death within 30 days. Overall, a total of 1,000 patients were enrolled in the study. A severe course of CAP was observed in 105 (10.5%) patients.
Results
The highest IL-6, IL-10 and LBP concentrations were found in patients with CRB-65 scores of 3-4 or CRB scores of 2-3. IL-6 and LBP levels on enrollment in the study were significantly higher for patients with a severe course of CAP than for those who did not have severe CAP. In receiver operating characteristic analyses, the area under the curve values for of IL-6 (0.689), IL-10 (0.665) and LPB (0.624) in a severe course of CAP were lower than that of CRB-65 (0.764) and similar to that of CRB (0.69). The accuracy of both CRB and CRB-65 was increased significantly by including IL-6 measurements. In addition, higher cytokine concentrations were found in patients with typical bacterial infections compared with patients with atypical or viral infections and those with infection of unknown etiology. LBP showed the highest discriminatory power with respect to the etiology of infection.
Conclusions
IL-6, IL-10 and LBP concentrations were increased in patients with a CRB-65 score of 3-4 and a severe course of CAP. The concentrations of IL-6 and IL-10 reflected the severity of disease in patients with CAP. The predictive power of IL-6, IL-10 and LBP for a severe course of pneumonia was lower than that of CRB-65. Typical bacterial pathogens induced the highest LBP, IL-6 and IL-10 concentrations.
Keywords: Interleukin-6, Interleukin-10, LBP, CAP, Pneumonia, Biomarker, Cytokine
Articles from BMC Pulmonary Medicine are provided here courtesy of
BioMed Central