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Biomark Insights. 2012; 7: 19–26.
Published online Mar 14, 2012. doi:  10.4137/BMI.S9060
PMCID: PMC3308681
Evaluation of Ischemia-Modified Albumin and C-Reactive Protein in Type 2 Diabetics With and Without Ketosis
Shao-gang Ma,1* Yao Jin,2* Wen Hu,1 Feng Bai,1 Wen Xu,1 and Wei-nan Yu1
1Department of Endocrinology and Metabolism, the Affiliated Huai’an Hospital of Xuzhou Medical College
2Department of Clinical Laboratory, the Affiliated Huai’an Hospital of Xuzhou Medical College
Corresponding author email: mashaogang/at/
*Co-first authors.
To investigate whether serum ischemia-modified albumin or C-reactive protein is reliable for predicting type 2 diabetic patients with ketosis.
One hundred and four diabetic patients, 48 with diabetic ketosis, and 33 controls were enrolled in the study. Serum ischemia-modified albumin and C-reactive protein were measured and evaluated for their ability to distinguish diabetic ketosis.
Compared to the controls, the ischemia-modified albumin and C-reactive protein levels were higher in patients with diabetic ketosis and type 2 diabetes at the baseline. The levels of ischemia-modified albumin were higher in patients with type 2 diabetes than in the controls. C-reactive protein and ischemia-modified albumin levels were reduced after insulin treatment. The level of ischemia-modified albumin was an independent risk marker for diabetic ketosis (OR = 1.085, P = 0.008, 95% CI: 1.022–1.152). Receiver operating characteristic curves revealed that the areas under the curve were 0.917 for the modified albumin and 0.357 for C-reactive protein.
This study indicates that ischemia-modified albumin was significantly associated with diabetic ketosis and was more sensitive than C-reactive protein in reflecting diabetic ketosis.
Keywords: diabetic ketosis, ischemia-modified albumin, C-reactive protein, biomarker
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