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BMC Med. 2012; 10: 17.
Published online Feb 15, 2012. doi:  10.1186/1741-7015-10-17
PMCID: PMC3308206
Is the efficacy of psychopharmacological drugs comparable to the efficacy of general medicine medication?
Florian Seemüller,corresponding author1 Hans-Jürgen Möller,1 Sandra Dittmann,1 and Richard Musil1
1Ludwig-Maximilian-University of Munich, Department of Psychiatry and Psychotherapy, Nussbaumstr.7, 80336 Munich, Germany
corresponding authorCorresponding author.
Florian Seemüller: fseemuel/at/med.lmu.de; Hans-Jürgen Möller: hans-juergen.moeller/at/med.uni-muenchen.de; Sandra Dittmann: sandra.dittmann/at/med.uni-muenchen.de; Richard Musil: richard.musil/at/med.uni-muenchen.de
Received January 26, 2012; Accepted February 15, 2012.
Abstract
There is an ongoing debate concerning the risk benefit ratio of psychopharmacologic compounds. With respect to the benefit, recent reports and meta-analyses note only small effect sizes with comparably high placebo response rates in the psychiatric field. These reports together with others lead to a wider, general critique on psychotropic drugs in the scientific community and in the lay press. In a recently published article, Leucht and his colleagues compare the efficacy of psychotropic drugs with the efficacy of common general medicine drugs in different indications according to results from reviewed meta-analyses. The authors conclude that, overall, the psychiatric drugs were generally not less effective than most other medical drugs. This article will highlight some of the results of this systematic review and discuss the limitations and the impact of this important approach on the above mentioned debate.
Keywords: effect size, general medicine, psychiatry, meta-analysis
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