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BMC Biol. 2012; 10: 27.
Published online Mar 19, 2012. doi:  10.1186/1741-7007-10-27
PMCID: PMC3307485
Regulation of G protein-coupled receptors by palmitoylation and cholesterol
Alan D Goddard1 and Anthony Wattscorresponding author1
1Biomembrane Structure Unit, Department of Biochemistry, University of Oxford, South Parks Rd, Oxford, OX1 3QU, UK
corresponding authorCorresponding author.
Alan D Goddard: alan.goddard/at/bioch.ox.ac.uk; Anthony Watts: anthony.watts/at/bioch.ox.ac.uk
Received March 1, 2012; Accepted March 19, 2012.
Abstract
Due to their membrane location, G protein-coupled receptors (GPCRs) are subject to regulation by soluble and integral membrane proteins as well as membrane components, including lipids and sterols. GPCRs also undergo a variety of post-translational modifications, including palmitoylation. A recent article by Zheng et al. in BMC Cell Biology demonstrates cooperative roles for receptor palmitoylation and cholesterol binding in GPCR dimerization and G protein coupling, underlining the complex regulation of these receptors.
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