Int J Epidemiol. 2012 February; 41(1): 250–262.
Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2012; all rights reserved.
Complement factor H genetic variant and age-related macular degeneration: effect size, modifiers and relationship to disease subtype
1Centre for Clinical Pharmacology, Department of Medicine, University College London, London, UK, 2Genetic Epidemiology Group, Department of Epidemiology and Public Health, 1-19 Torrington Place, University College London, London, UK, 3Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK, 4Institute of Ophthalmology, University College London, London, UK, 5Moorfields Eye Hospital, London, UK, 6Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK, 7Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, 8Neurobiology-Neurodegeneration & Repair Laboratory (N-NRL), National Eye Institute, National Institutes of Health, Bethesda, MD, USA, 9Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA, 10Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA, 11Department of Ophthalmogenetics, Meibergdreef 47, The Netherlands, The Netherlands Institute for Neuroscience (NIN-KNAW), 12Department of Clinical Genetics, Meibergdreef 47, The Netherlands, The Netherlands Institute for Neuroscience (NIN-KNAW), 13Ophthalmology, Academic Medical Centre Amsterdam (AMC/UvA), The Netherlands, 14Institute for Genomic Medicine and Department of Ophthalmology, University of California San Diego 9500 Gilman Drive, La Jolla, CA, USA, 15Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah, 16Institute of Human Genetics, University of Regensburg, Franz-Josef-Strauss-Allee 11, Germany, 17Eye Hospital, University of Wuerzburg Josef-Schneider-Str. 11, Germany, 18Division of Clinical Neurosciences, Southampton General Hospital, University of Southampton, 19Centre National de Génotypage, 2 rue Gaston Crémieux, CP 5721, 91 057 Evry Cedex, France, and Fondation Jean Dausset Ceph, 27 rue Juliette Dodu 75010 Paris, France, 20UPMC Univ Paris 06, UMR_S 968, Institut de la Vision, INSERM, U968, CNRS, UMR_7210, Paris, F-75012, France, 21David Geffen School of Medicine - UCLA Jules Stein Eye Institute, 100 Stein Plaza (DSERC 3-310B) Los Angeles, CA, USA, 22Departments of Human Genetics and Biostatistics, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, 23Department of Statistics, University of Chicago, 5734 S. University Avenue, Eckhart 104 Chicago, IL, USA, 24Department of Health Promotion & Development, School of Nursing, PA, USA, 25Department of Epidemiology and Biostatistics, National Institute for Health Development, Estonia, 26Stavanger University Hospital, Stavanger, University of Bergen, Norway, 27Service d’Ophtalmologie - Université Paris, 28A’ Department of Ophthalmology, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece, 29University Miguel Hernandez and CIBER en Epidemiología y Salud Pública (CIBERESP), Spain. Dpto Salud Publica. Campus San Juan. Ctra. Nacional 332 s/n. 03550-San Juan de Alicante, Spain, 30Sezione di Oftalmologia del Dipartimento di Scienze Neurologiche e della Visione dell’Universita’ degli Studi di Verona, Ospedale di Borgo Trento – Padiglione Geriatrico – P.Stefani 1 - 37124 Verona, 31Centre for Public Health, 1st Floor ICS B Block, Royal Victoria Hospital, Grosvenor Road, Belfast BT12 6BJ, 32Statistical Platforms and Technologies, GlaxoSmithKline, Medicines Research Centre, Mailstop 1S101, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY and 33Centre for Vision and Vascular Science, Institute of Clinical Science, The Queen's University of Belfast
Accepted November 16, 2011.