In the title compound, C20H22BrN5O2·2H2O, the Schiff base molecule exists in an E conformation with respect to the acyclic C=N bond. An S(6) ring motif is formed via an intramolecular O—HN hydrogen bond. The dihedral angle between the imidazo[1,2-a]pyridine system and the benzene ring is 84.62 (5)°. In the crystal, N—HO, O—HO, O—HN, C—HO and C—HBr hydrogen bonds link the molecules into a three-dimensional network. The crystal packing is further stabilized by C—Hπ and π–π interactions [centroid–centroid distance = 3.5365 (7) Å].