This paper describes the use of high quality digital hand photographs for the diagnosis and severity grading of hand osteoarthritis. The study population was a random sample of 381 elderly (mean age 76) participants in the AGES-Reykjavik Study who also had standard hand radiographs and expert clinical hand examination in addition to the digital photographs.
In the first step of the study, we developed a set of reference photographs to facilitate the reading and grading of the hand photographs. These were chosen after repeated assessments. By the help of these reference photographs, we managed to achieve an interobserver agreement measured by ICC which is comparable to that reported in radiological studies [24
In the second phase of the study, we compared hand photographs with the results of radiography and clinical examination in the same group of individuals with regard to the diagnosis of HOA, and the grading of HOA severity. Unfortunately, the definition of HOA is very problematic because of lack of an absolute clinical, radiological, or pathological standard that the epidemiology of hand OA can be compared with. The ACR criteria for clinical diagnosis of HOA [27
] are useful for identifying HOA patients with persistent symptoms but the prevalence of HOA by those criteria is low. A study of an elderly population in Iceland based on the ACR criteria [13
] found that the prevalence of symptomatic hand OA was 3% in men and 7% in women. The symptoms criterion, however, showed considerable variation with time and thus the symptomatic OA group was not stable.
Radiological changes are most commonly used to grade hand OA. At present, several different radiographic classification systems are used but the Kellgren-Lawrence (K-L) scale for grading of radiological changes has been most widely used in the past [17
]. In a review by Marshall and colleagues in 2008 it was reported that in 1996-2005 thirty epidemiological studies, all using the K-L scale, used 13 different cut-off points for diagnosis of systemic HOA [28
]. The prevalence of symptomatic HOA is also low using the radiographic criteria, in the Framingham Study it had a point prevalence of 1.8-5.5% [29
In the present study, we found several differences between the three methods. Radiography was more sensitive than either of the other methods when the cut-off was set at K-L ≥ 2. Radiography also had a higher relative prevalence in the PIP joints than the other methods. Aggregate scores for all methods showed highly significant correlations and with few exceptions, they tended to identify the same individuals as having severe HOA. Not unexpectedly, photographs and clinical examination results were more closely correlated to each other than to radiography. There were a few individuals with high radiography scores and low photographic and clinical scores (non-nodal hand osteoarthritis), which may constitute a relevant subset of HOA and will be the subject of further studies. Agreement between the three methods was considerably better in females than males. Weight and BMI were negatively associated with photographic HOA scores but despite reports indicating a positive association between radiographic HOA and weight we found no such association [30
]. The photographic finding is not entirely unexpected and probably related to increased finger soft tissues hindering the detection of nodes and deformities.
Pain is the central symptom of OA and in the next phase of the study, we investigated the relationship between pain and HOA detected by the three methods.
Somewhat surprisingly, we found no association between HOA and pain in males except in those with CMC1 OA who admitted to pain in that joint. This could be related to the high age of our participants but some previous studies have reported a weaker association between radiographic HOA and pain in males than females [31
]. In females, we found only a modest similar association between "pain in hands lasting at least one month" and aggregate severity scores for all three methods. The prevalence of this symptom and the weak association are in analogy with that found in previous studies [7
]. Intermittent pain (pain sometimes) was more strongly related to HOA findings, both aggregate HOA scores and pain in individual joints. All three methods performed similarly in the case of the DIP joints, but radiography showed a somewhat stronger association with pain than photography for PIP and CMC1 joints. For the PIP joints, radiography also appeared superior to clinical examination.
In the final step of the study plan, we developed a shortened version of the photographic system. If information about HOA severity could be collected from some of the large detailed studies like the AGES-Reykjavik Study, it would open up a number of possibilities to examine the relationship of HOA to lifestyle and all kinds of conditions. If we consider HOA severity as a continous trait, the exact prevalences are less important than information the relative burden of HOA in each individual.
Using photographs for diagnosing HOA has a number of advantages. The method is simple, inexpensive, and involves little discomfort and no radiation. This study shows that the taking and the reading of the photographs can be standardized in a reproducible fashion with adequate inter- and intraobserver variation, at least in this age group. The photographic method in this age group is also in many ways comparable to the other methods, identifying mainly the same patients and showing comparable or only slightly inferior association with symptoms. Compared with clinical examination it also has the advantage of having an image for later analysis. The shortened version (HOASCORE) has practical advantages, speeding up the reading and appears to be particularly suitable for analysis of very large studies such as the AGES-Reykjavik Study where information about HOA status can be analysed in relation to the extensive health-related information available on each participant. By applying the HOASCORE to the AGES-Reykjavik Study population, we have discovered a number of potentially important new systemic associations, undetectable except in large studies [4
The disadvantages of photography is that it is less sensitive on joint for joint analysis than either radiography and clinical examination particularly on PIP and CMC1 analysis. Also, compared with radiography it reflects anatomy less well. Bone damage or repair cannot be evaluated and the method cannot be used to diagnose erosive OA. The photographic scores also negatively associated with individual weight suggesting lower sensitivity in heavy subjects. Finally, a recent study suggests that photographic scoring of HOA is relatively insensitive to change, at least in this age group [34
Of course, our conclusions regarding the use of photographs to diagnose HOA are limited to the current age group. In many ways this is a suitable age group to examine since it reflects cumulative disease burden and organ damage aquired over a long time. There is no reason to believe that photography performs differently in other age groups. In the future, it is even possible that photographs will prove to be more sensitive than radiographs in younger subjects with early disease who have nodal HOA but have not had time to develop radiological changes.