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Nucleic Acids Res. Oct 11, 1991; 19(19): 5285–5291.
PMCID: PMC328889
An erythroid specific enhancer upstream to the gene encoding the cell-type specific transcription factor GATA-1.
S Nicolis, C Bertini, A Ronchi, S Crotta, L Lanfranco, E Moroni, B Giglioni, and S Ottolenghi
Dipartimento di Genetica e di Biologia dei Microrganismi, Università di Milano, Italy.
Abstract
The transcription factor GATA-1 is expressed in a subset of hemopoietic cells, where it mediates the cell-type specific expression of several genes. We have cloned the mouse and human GATA-1 genes. A region upstream to the first exon, and highly conserved between mouse and man, acts as an erythroid specific enhancer in transient assays, if linked to the GATA-1 or to the SV40 promoter. The activity of the enhancer is almost completely dependent on the integrity of a dimeric GATA-1 binding site.
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