PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of bmccancBioMed Centralsearchsubmit a manuscriptregisterthis articleBMC Cancer
 
BMC Cancer. 2012; 12: 11.
Published online Jan 12, 2012. doi:  10.1186/1471-2407-12-11
PMCID: PMC3274437
Incidence and survival of oesophageal and gastric cancer in England between 1998 and 2007, a population-based study
Victoria H Coupland,corresponding author1 William Allum,2 Jane M Blazeby,3,6 Michael A Mendall,4 Richard H Hardwick,5 Karen M Linklater,1 Henrik Møller,1 and Elizabeth A Davies1
1King's College London, Thames Cancer Registry, 1st Floor Capital House, 42, Weston Street, London SE1 3QD, UK
2Royal Marsden Hospital, London, UK
3University of Bristol, Bristol, UK
4Mayday Hospital, Croydon, UK
5Addenbrooke's Hospital, Cambridge, UK
6University Hospitals Bristol NHS Foundation Trust, Bristol, UK
corresponding authorCorresponding author.
Victoria H Coupland: victoria.coupland/at/kcl.ac.uk; William Allum: William.Allum/at/rmh.nhs.uk; Jane M Blazeby: J.M.Blazeby/at/bristol.ac.uk; Michael A Mendall: mike.mendall/at/mayday.nhs.uk; Richard H Hardwick: richard.hardwick/at/addenbrookes.nhs.uk; Karen M Linklater: karen.linklater/at/kcl.ac.uk; Henrik Møller: henrik.moller/at/kcl.ac.uk; Elizabeth A Davies: elizabeth.davies/at/kcl.ac.uk
Received August 31, 2011; Accepted January 12, 2012.
Abstract
Background
Major changes in the incidence of oesophageal and gastric cancers have been reported internationally. This study describes recent trends in incidence and survival of subgroups of oesophageal and gastric cancer in England between 1998 and 2007 and considers the implications for cancer services and policy.
Methods
Data on 133,804 English patients diagnosed with oesophageal and gastric cancer between 1998 and 2007 were extracted from the National Cancer Data Repository. Using information on anatomical site and tumour morphology, data were divided into six groups; upper and middle oesophagus, lower oesophagus, oesophagus with an unspecified anatomical site, cardia, non-cardia stomach, and stomach with an unspecified anatomical site. Age-standardised incidence rates (per 100,000 European standard population) were calculated for each group by year of diagnosis and by socioeconomic deprivation. Survival was estimated using the Kaplan-Meier method.
Results
The majority of oesophageal cancers were in the lower third of the oesophagus (58%). Stomach with an unspecified anatomical site was the largest gastric cancer group (53%). The incidence of lower oesophageal cancer increased between 1998 and 2002 and remained stable thereafter. The incidence of cancer of the cardia, non-cardia stomach, and stomach with an unspecified anatomical site declined over the 10 year period. Both lower oesophageal and cardia cancers had a much higher incidence in males compared with females (M:F 4:1). The incidence was also higher in the most deprived quintiles for all six cancer groups. Survival was poor in all sub-groups with 1 year survival ranging from 14.8-40.8% and 5 year survival ranging from 3.7-15.6%.
Conclusions
An increased focus on prevention and early diagnosis, especially in deprived areas and in males, is required to improve outcomes for these cancers. Improved recording of tumour site, stage and morphology and the evaluation of focused early diagnosis programmes are also needed. The poor long-term survival reinforces the need for early detection and multidisciplinary care.
Articles from BMC Cancer are provided here courtesy of
BioMed Central