An infectious actiology has often been discussed as a most compatible with both the clinical and pathological features of rheumatoid arthritis /RA/. Until now, no single microorganism can be showed as consistently associated with development of RA. In our former serological and molecular studies we have shown that the most common humoral immune answer in RA patients is directed to Salmonella enteritidis /S. ent./ antigens, especially to specific for Salmonella enteritidis 03 LPS.
The aim of the study was to proof the correlation between systemic and local humoral immune answer to Salmonella enteritidis antigens and the presence of DNA specific for Salmonella enteritidis 03 serotype.