PMCCPMCCPMCC

Search tips
Search criteria 

Advanced


 
Formats
Article sections
Authors
Logo of arthresbiomed central web sitesearch.manuscript submission.see also journal with issn 1478-6354registration.reference to the article.journal front page.
 
Arthritis Res. 2001; 3(Suppl A): P110.
Published online 2001 January 26. doi:  10.1186/ar279
PMCID: PMC3273253
Copyright ©2001 BioMed Central Ltd
Time to lupus nephritis: impact of gender and ethnicity
VA Seligman,1 H Li,1 JL Olson,1 and LA Criswell1
1Department of Medicine, UCSF, San Francisco, CA 94143-0633 Department of Human Genetics, UCD, Davis, CA 95616, USA
Supplement
21st European Workshop for Rheumatology Research
Conference
21st European Workshop for Rheumatology Research
1-4 March 2001
Vienna, Austria
Received January 15, 2001
Objective
There is a paucity of literature regarding the time to development of nephritis among SLE patients. Our goal was to define this important parameter for a large multi-ethnic cohort, with an emphasis on the impact of gender and ethnicity.
Methods
779 SLE patients with disease satisfying the ACR criteria were classified as non-nephritis or definite nephritis patients based on questionnaire and comprehensive medical record review. Patients classified with definite nephritis fulfilled the criteria of proteinuria (> 0.5 g per 24 hrs), active sediment, or renal biopsy consistent with SLE. 716 (92%) were female. The ethnic distribution was: Caucasian 453 (58.2%), Hispanic 123 (15.8%), Asian 97 (12.4%), African American 75 (9.6%), and other 36 (4.6%). The annual rates of developing nephritis among different gender and ethnic subgroups were derived using Kaplan-Meier estimates.
Results
The table shows gender and ethnicity based Kaplan-Meier estimates of the proportion of patients with nephritis at designated time intervals. The curves are significantly different for males vs. females and Caucasians vs. non-Caucasians based on the log-rank test. The curves for Hispanic, Asian and African American subgroups did not differ significantly.
Table 1
Table 1
Conclusions
These results are a significant contribution to the data regarding time to development of nephritis in SLE, and emphasize the important influence gender and ethnicity.
Articles from Arthritis Research are provided here courtesy of
BioMed Central