Interleukin-18 (IL-18) has been demonstrated as promoting the development of a TH1 response in vivo in synergy with IL-12. Significant levels of IL-18 and IL-12 have been detected in the joints of patients with rheumatoid arthritis (RA).
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Arthritis Res. 2001; 3(Suppl A): P092.
Published online Jan 26, 2001. doi: 10.1186/ar261