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Arthritis Res. 2001; 3(Suppl A): P034.
Published online 2001 January 26. doi:  10.1186/ar203
PMCID: PMC3273239

Elevated levels of soluble intercellular adhesion molecule -1 in systemic lupus erythematosus

Objective

To assess the value of measuring serum levels of soluble intercellular adhesion molecule 1 (sICAM-1) in systemic lupus erythematosus (SLE).

Material and methods

We studied 35 patients (pts) (7 female, 28 male), satisfying the ACR criteria for SLE. Mean age of pts was 31,4 ± 12,0 years (range 17-63), mean disease duration was 81,8 ± 70,5 month (range 2-240). Disease activity was assessed by disease activity indices (SLAM, SLEDAI). Enzyme-linked immunosorbent assay was used to measure levels of sICAM-1 (R$D, USA). The results were compared with 18 healthy subjects.

Results

Levels of sICAM-1 were found elevated (more than 2 SD above the mean in normal controls, 443 ng/ml) in 7 of 35 (20%) pts with SLE. The relations between positive sICAM-1 and some clinical manifestations of SLE have been detected. We found significant correlation between individual sICAM-1 serum level and the SLEDAI (r=043) and SLAM (r=0,56) scores, and ESR (r=0,53).

Conclusion

Elevated serum levels of sICAM-1 can be found in SLE and correlate with disease activity. Longitudinal studies may establish their clinical value in the monitoring or the prognosis of patients.


Articles from Arthritis Research are provided here courtesy of BioMed Central