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Logo of arthresbiomed central web sitesearch.manuscript submission.see also journal with issn 1478-6354registration.reference to the article.journal front page.
Arthritis Res. 2001; 3(Suppl A): P103.
Published online Jan 26, 2001. doi:  10.1186/ar272
PMCID: PMC3273235
The shared epitope revisited: shared epitope negative HLA-DR alleles influence susceptibility to rheumatoid arthritis
D Reviron,1 A Perdriger,1 E Toussirot,1 D Wendling,1 N Balandraud,1 S Guis,1 G Semana,1 P Tiberghien,1 P Mercier,1 and J Roudier1
1INSERM EMI9940, Rheumatology Ward La Conception and EFS Histocompatibility, Marseille, France; Rheumatology Ward and EFS Histocompatibility Rennes, France; Rheumatology Ward and EFS Histocompatibility, Besançon; France
21st European Workshop for Rheumatology Research
21st European Workshop for Rheumatology Research
1-4 March 2001
Vienna, Austria
Received January 15, 2001
We propose to classify HLA-DRB1 alleles into 3 groups: shared epitope positive (SE), shared epitope negative with a positively charged HLA-DR P4 pocket (XP4p) and shared epitope negative with a negative or neutral HLA-DR XP4 pocket (XP4n). Using this classification to analyse 3 different French populations, we find that:
-SE/SE or SE/XP4p genotypes are associated with a high risk to develop RA.
-XP4p/XP4p or SE/XP4n genotypes are neutral
-XP4p/XP4p or XP4n/XP4n genotypes are protective with respect to the development of RA.
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