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Logo of arthresbiomed central web sitesearch.manuscript submission.see also journal with issn 1478-6354registration.reference to the article.journal front page.
Arthritis Res. 2001; 3(Suppl A): P104.
Published online Jan 26, 2001. doi:  10.1186/ar273
PMCID: PMC3273214
Positivity of HLA-DRB1 rheumatoid epitope does not predict the course of juvenile idiopathic arthritis in Czech children
O Cinek,1 P Vavrincová,1 P Drevínek,1 M Suková,1 S Rádová,2 and J Vavrinec1
12nd Paediatric Department, 2nd Medical Faculty
2University Hospital Motol, Prague, Czech Republic
21st European Workshop for Rheumatology Research
21st European Workshop for Rheumatology Research
1-4 March 2001
Vienna, Austria
Received January 15, 2001
Association of juvenile idiopathic arthritis (JIA) with HLA class II still remains unresolved. Our study investigated whether presence of the HLA-DRB1 amino acid 70-74 rheumatoid epitope (RE) is a predictive factor of the disease course.
Patients and methods
We analysed 74 consecutive patients with JIA diagnosed and classified according to ILAR criteria, aged 11.2 ± 4.2 (mean ± SD), 35 boys and 39 girls. The numbers of children having oligoarticular, polyarticular, and systemic form of JIA were 24, 40, and 10, respectively. HLA-DRB1 alleles carrying the QRRAA, QKRAA, and RRRAA motifs of RE were typed for using PCR with sequence-specific primers.
Results and Conclusions
There were no significant differences in frequency of the RE, or its particular motifs, among the three forms of JIA.
We therefore conclude that simple positivity of the DRB1 rheumatoid epitope is not a likely predictive factor of the JIA course in Czech children.
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