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Logo of arthresbiomed central web sitesearch.manuscript submission.see also journal with issn 1478-6354registration.reference to the article.journal front page.
 
Arthritis Res. 2001; 3(Suppl A): P113.
Published online Jan 26, 2001. doi:  10.1186/ar282
PMCID: PMC3273207
Nucleosome binding by serum amyloid P component from SLE patients
NHH Heegaard,1 L Rahbek,1 and C Recke1
1Department of Autoimmunology, Statens Serum Institut, Copenhagen, Denmark
Supplement
21st European Workshop for Rheumatology Research
Conference
21st European Workshop for Rheumatology Research
1-4 March 2001
Vienna, Austria
Received January 15, 2001
 
There is evidence in favor of apoptosis dysfunction being involved in the pathogenesis of SLE. Since mice deficient in the nucleosome-binding protein: serum amyloid P component (SAP) develop antinuclear immunity and nephritis it is possible that impaired clearance of nuclear material from apoptotic cells is the key defect. We therefore developed a solid-phase assay for the binding of SAP to nucleosomes and investigated the nucleosome binding characteristics of SAP from 20 different SLE patients as compared with normal donors. We could not demonstrate any significant differences between the groups and therefore the functions of other pentraxins (such as C-reactive protein) or DNA binding molecules (such as C1q) will be examined in future studies.
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