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Arthritis Res. 2001; 3(Suppl A): P077.
Published online Jan 26, 2001. doi:  10.1186/ar246
PMCID: PMC3273203
Immuno-serological profile of Systemic Erythemic Lupus (SLE) patients with neuropsychiatric manifestations (NP)
L Stojanovich,1 V Mircetic,2 R Stojanovich,2 V Kostich,3 and D Popovich1
1Hospital Center "Bezhanijska Kosa", Belgrade, Yugoslavia
2Institute for Rheumatology, Belgrade, Yugoslavia
3Institute for Neurology, Belgrade, Yugoslavia
Supplement
21st European Workshop for Rheumatology Research
Conference
21st European Workshop for Rheumatology Research
1-4 March 2001
Vienna, Austria
Received January 15, 2001
Introduction
goal of the study was to establish the correlation between immuno-serological anomalies and the existence of NP in patients with SLE
the study included 60 SLE patients (54 female, 6 male), all with signs of NP. The age of patients varied between 17 and 71 years (42.3 + 13.0). The study consisted of clinical evaluation by rheumatologist, neurologist, psychiatrist, neuro-ophtalmologist, as well as electrophysiological (EEG, EP, EMNG) methods. It also included visualization (NMR) methods for determining pathologies in the CNS. Different auto-antibodies and other immuno-serological markers displayed positive results with the following frequency: ANA (91.7%); anti-dsDNA (40.0%); anti-DNP (48.3%); CIK (45.0%); low C3/C4 levels (18.3%). Antiphospholipid antibodies (aPL) were positive: LA in 14.8% pts; aCL (IgG and IgM) in 23.1% pts. 30 patients were tested for anti-SM, anti-U1RNP, cANCA and pANCA and were positive in: anti-SM- 20.0%, anti-U1RNP- 50.0%, cANCA- 10.0%, pANCA- 30.0%.
Results
there was no statistically significant correlation between ANA, anti-dsDNA, CIK, anti-DNP, C3/C4 and the diagnosis of certain neuro-psychiatric manifestations in our SLE patient group. Patients with focal cerebral dysfunctions were shown to have a higher frequency of aPL: LA (P = 0.0111) and aCL (P = 0.0148). A correlation was found between cANCA (P = 0.0406), pANCA (P = 0.0348), anti-U1RNP (P = 0.0309) and skin vasculitis, as well as between pANCA and CVI diagnosis in neuro-lupus patients (P = 0.0028).
Conclusion
our study did not show the correlation between auto-antibodies in SLE patients with NP and certain types of CNS/PNS lesions, except for the connection between aPL and focal cerebral dysfunctions, as well as pANCA's correlation with cerebro-vascular stroke diagnosis.
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